PDB: 22592 件ウェブページステータス検索Chemie searchBIRD

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5DU6	Crystal structure of M. tuberculosis EchA6 bound to ligand GSK059A. 分子名称: (5R,7R)-5-(4-ethylphenyl)-N-(4-fluorobenzyl)-7-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide, Probable enoyl-CoA hydratase echA6 著者 Cox, J.A.G, Besra, G.S, Futterer, K. 登録日 2015-09-18 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria. Nat Microbiol, 1, 2016
3HNZ	Structure of E. coli FabF(C163A) in Complex with Platensimycin 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, PLATENSIMYCIN 著者 Soisson, S.M, Parthasarathy, G. 登録日 2009-06-01 公開日 2010-02-09 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis. Bioorg.Med.Chem.Lett., 19, 2009
6W6G	The Mycobacterium tuberculosis ClpB disaggregase hexamer structure in conformation I in the presence of DnaK chaperone and a model substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Yin, Y, Li, H. 登録日 2020-03-16 公開日 2021-03-17 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system. Cell Rep, 35, 2021
6W6H	The Mycobacterium tuberculosis ClpB disaggregase hexamer structure in conformation II in the presence of DnaK chaperone and a model substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Yin, Y, Li, H. 登録日 2020-03-16 公開日 2021-05-26 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system. Cell Rep, 35, 2021
6W6J	The Mycobacterium tuberculosis ClpB disaggregase hexamer structure with a locally refined N-terminal domain in the presence of DnaK chaperone and a model substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Yin, Y, Li, H. 登録日 2020-03-17 公開日 2021-05-26 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system. Cell Rep, 35, 2021
6W6I	The Mycobacterium tuberculosis ClpB disaggregase hexamer structure in conformation T in the presence of DnaK chaperone and a model substrate 分子名称: ADENOSINE-5'-DIPHOSPHATE, Chaperone protein ClpB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... 著者 Yin, Y, Li, H. 登録日 2020-03-17 公開日 2021-05-26 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system. Cell Rep, 35, 2021
8AHW	Structure of DCS-resistant variant D322N of alanine racemase from Mycobacterium tuberculosis 分子名称: 1,2-ETHANEDIOL, Alanine racemase, GLYCEROL 著者 de Chiara, C, Prosser, G, Ogrodowicz, R.W, de Carvalho, L.P.S. 登録日 2022-07-22 公開日 2023-04-05 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Structure of the d-Cycloserine-Resistant Variant D322N of Alanine Racemase from Mycobacterium tuberculosis . Acs Bio Med Chem Au, 3, 2023
5F31	Crystal structure of membrane associated PatA from Mycobacterium smegmatis in complex with palmitate - P 42 21 2 space group 分子名称: ETHANOL, PALMITIC ACID, Phosphatidylinositol mannoside acyltransferase, ... 著者 Albesa-Jove, D, Svetlikova, Z, Carreras-Gonzalez, A, Tersa, M, Sancho-Vaello, E, Cifuente, J.O, Mikusova, K, Guerin, M.E. 登録日 2015-12-02 公開日 2016-03-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA. Nat Commun, 7, 2016
3I8P	Crystal structure of E. coli FabF(C163A) in complex with Platensimycin A1 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, Platensimycin A1 著者 Soisson, S.M, Parthsarathy, G. 登録日 2009-07-09 公開日 2010-07-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis. Bioorg.Med.Chem.Lett., 19, 2009
5F2Z	Crystal structure of membrane associated PatA from Mycobacterium smegmatis in complex with palmitate - P21 space group 分子名称: PALMITIC ACID, Phosphatidylinositol mannoside acyltransferase 著者 Albesa-Jove, D, Svetlikova, Z, Carreras-Gonzalez, A, Tersa, M, Sancho-Vaello, E, Cifuente, J.O, Mikusova, K, Guerin, M.E. 登録日 2015-12-02 公開日 2016-03-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA. Nat Commun, 7, 2016
8A9P	Crystal structure of CYP142 from Mycobacterium tuberculosis in complex with a fragment 分子名称: (3-phenyl-1,2,4-oxadiazol-5-yl)methanamine, BROMIDE ION, CHLORIDE ION, ... 著者 Snee, M, Katariya, M, Levy, C, Leys, D. 登録日 2022-06-29 公開日 2023-07-12 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Crystal structure of CYP142 from Mycobacterium tuberculosis in complex with a fragment To Be Published
5F34	Crystal structure of membrane associated PatA from Mycobacterium smegmatis in complex with S-hexadecyl Coenzyme A - P21 space group 分子名称: Phosphatidylinositol mannoside acyltransferase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{S})-4-[[3-(2-hexadecylsulfanylethylamino)-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate 著者 Albesa-Jove, D, Svetlikova, Z, Carreras-Gonzalez, A, Tersa, M, Sancho-Vaello, E, Cifuente, J.O, Mikusova, K, Guerin, M.E. 登録日 2015-12-02 公開日 2016-03-09 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.281 Å) 主引用文献 Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA. Nat Commun, 7, 2016
6XPP	Crystal structure of itaconate modified Mycobaterium tuberculosis isocitrate lyase 分子名称: 2-methylidenebutanedioic acid, Isocitrate lyase, MAGNESIUM ION 著者 Kwai, B.X.C, Bashiri, G, Leung, I.K.H. 登録日 2020-07-08 公開日 2020-10-21 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase. Rsc Med Chem, 12, 2021
2PKM	Crystal structure of M tuberculosis Adenosine Kinase complexed with adenosine 分子名称: ADENOSINE, Adenosine kinase 著者 Reddy, M.C.M, Palaninathan, S.K, Shetty, N.D, Owen, J.L, Watson, M.D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2007-04-17 公開日 2007-06-26 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme J.Biol.Chem., 282, 2007
2PKK	Crystal structure of M tuberculosis Adenosine Kinase complexed with 2-fluro adenosine 分子名称: 2-(6-AMINO-2-FLUORO-PURIN-9-YL)-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3,4-DIOL, Adenosine kinase 著者 Reddy, M.C.M, Palaninathan, S.K, Shetty, N.D, Owen, J.L, Watson, M.D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2007-04-17 公開日 2007-06-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme J.Biol.Chem., 282, 2007
2B35	Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by triclosan 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN 著者 Sullivan, T.J, Truglio, J.J, Novichenok, P, Stratton, C, Zhang, X, Kaur, T, Johnson, F, Boyne, M.S, Amin, A. 登録日 2005-09-19 公開日 2006-03-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis ACS Chem.Biol., 1, 2006
3HST	N-Terminal RNASE H domain of rv2228c from mycobacterium tuberculosis as a fusion protein with maltose binding protein 分子名称: 1,2-ETHANEDIOL, D(-)-TARTARIC ACID, Maltose-binding periplasmic protein, ... 著者 Watkins, H.A, Baker, E.N. 登録日 2009-06-10 公開日 2010-04-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis. J.Bacteriol., 192, 2010
1UUN	Main porin from Mycobacterium smegmatis (MspA) 分子名称: MSPA 著者 Faller, M, Niederweis, M, Schulz, G.E. 登録日 2004-01-08 公開日 2004-02-26 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The Structure of a Mycobacterial Outer-Membrane Channel Science, 303, 2004
2PKN	Crystal structure of M tuberculosis Adenosine Kinase complexed with AMP-PCP (non-hydrolyzable ATP analog) 分子名称: Adenosine kinase, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER 著者 Reddy, M.C.M, Palaninathan, S.K, Shetty, N.D, Owen, J.L, Watson, M.D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2007-04-18 公開日 2007-06-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme J.Biol.Chem., 282, 2007
2PKF	Crystal structure of M tuberculosis Adenosine Kinase (apo) 分子名称: Adenosine kinase 著者 Reddy, M.C.M, Palaninathan, S.K, Shetty, N.D, Owen, J.L, Watson, M.D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2007-04-17 公開日 2007-06-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme J.Biol.Chem., 282, 2007
3GWZ	Structure of the Mitomycin 7-O-methyltransferase MmcR 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, MmcR, ... 著者 Singh, S, Chang, A, Bingman, C.A, Phillips Jr, G.N, Thorson, J.S. 登録日 2009-04-01 公開日 2010-04-07 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Structural characterization of the mitomycin 7-O-methyltransferase. Proteins, 79, 2011
2B37	Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by 5-octyl-2-phenoxyphenol 分子名称: 5-OCTYL-2-PHENOXYPHENOL, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Sullivan, T.J, Truglio, J.J, Novichenok, P, Stratton, C, Zhang, X, Kaur, T, Johnson, F, Boyne, M.S, Amin, A. 登録日 2005-09-19 公開日 2006-03-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis ACS Chem.Biol., 1, 2006
2B36	Crystal structure of Mycobacterium tuberculosis enoyl reductase (InhA) inhibited by 5-pentyl-2-phenoxyphenol 分子名称: 5-PENTYL-2-PHENOXYPHENOL, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Sullivan, T.J, Truglio, J.J, Novichenok, P, Stratton, C, Zhang, X, Kaur, T, Johnson, F, Boyne, M.S, Amin, A. 登録日 2005-09-19 公開日 2006-03-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 High Affinity InhA Inhibitors with Activity against Drug-Resistant Strains of Mycobacterium tuberculosis ACS Chem.Biol., 1, 2006
2M5Y	Solution Structure of the C-terminal domain of RV0431 分子名称: Putative tuberculin related peptide 著者 Huang, C, Wang, T, Li, H. 登録日 2013-03-13 公開日 2014-02-26 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.USA, 110, 2013
8PXZ	Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with natural substrate 分子名称: (2~{R})-2-[[(2~{S},6~{R})-6,7-bis(azanyl)-2-[[(4~{R})-4,5-bis(azanyl)-5-oxidanylidene-pentanoyl]amino]-7-oxidanylidene-heptanoyl]amino]propanoic acid, (2~{R})-2-azanyl-~{N}'-[(2~{S},6~{R})-6,7-bis(azanyl)-1-oxidanyl-7-oxidanylidene-heptan-2-yl]pentanediamide, 1,2-ETHANEDIOL, ... 著者 de Munnik, M, Schofield, C.J. 登録日 2023-07-24 公開日 2024-08-07 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Crystal structure of the transpeptidase LdtMt2 from Mycobacterium tuberculosis in complex with natural substrate To Be Published

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