6XPP

Crystal structure of itaconate modified Mycobaterium tuberculosis isocitrate lyase

Summary for 6XPP

• Entry DOI: 10.2210/pdb6xpp/pdb
• Descriptor: Isocitrate lyase, 2-methylidenebutanedioic acid, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: covalent modification, lyase
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 4
• Total formula weight: 189252.40

Authors

Kwai, B.X.C.,Bashiri, G.,Leung, I.K.H. (deposition date: 2020-07-08, release date: 2020-10-21, Last modification date: 2023-10-18)

• Primary citation: Kwai, B.X.C.,Collins, A.J.,Middleditch, M.J.,Sperry, J.,Bashiri, G.,Leung, I.K.H.; Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase.; Rsc Med Chem, 12:57-61, 2021; PubMed: 34046597; DOI: 10.1039/d0md00301h

Experimental method

X-RAY DIFFRACTION (1.55 Å)