5DU6

Crystal structure of M. tuberculosis EchA6 bound to ligand GSK059A.

Summary for 5DU6

Entry DOI	10.2210/pdb5du6/pdb
Descriptor	Probable enoyl-CoA hydratase echA6, (5R,7R)-5-(4-ethylphenyl)-N-(4-fluorobenzyl)-7-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide (3 entities in total)
Functional Keywords	enoyl-coa hydratase-like, lyase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	3
Total formula weight	85867.97
Authors	Cox, J.A.G.,Besra, G.S.,Futterer, K. (deposition date: 2015-09-18, release date: 2016-01-20, Last modification date: 2024-01-10)
Primary citation	Cox, J.A.,Abrahams, K.A.,Alemparte, C.,Ghidelli-Disse, S.,Rullas, J.,Angulo-Barturen, I.,Singh, A.,Gurcha, S.S.,Nataraj, V.,Bethell, S.,Remuinan, M.J.,Encinas, L.,Jervis, P.J.,Cammack, N.C.,Bhatt, A.,Kruse, U.,Bantscheff, M.,Futterer, K.,Barros, D.,Ballell, L.,Drewes, G.,Besra, G.S. THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria. Nat Microbiol, 1:15006-15006, 2016 Cited by PubMed: 27571973 DOI: 10.1038/nmicrobiol.2015.6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.61 Å)

Structure validation