5T3A
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5T44
| Crystal structure of Frizzled 7 CRD | 分子名称: | Frizzled-7 | 著者 | Mukund, S, Nile, A.H, Stanger, K, Hannous, R.H, Wang, W. | 登録日 | 2016-08-29 | 公開日 | 2017-04-05 | 最終更新日 | 2017-05-03 | 実験手法 | X-RAY DIFFRACTION (1.9944 Å) | 主引用文献 | Unsaturated fatty acyl recognition by Frizzled receptors mediates dimerization upon Wnt ligand binding. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5SZV
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5T1A
| Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2~{R})-1-(4-chloranyl-2-fluoranyl-phenyl)-2-cyclohexyl-3-ethanoyl-4-oxidanyl-2~{H}-pyrrol-5-one, (3S)-1-{(1S,2R,4R)-4-[methyl(propan-2-yl)amino]-2-propylcyclohexyl}-3-{[6-(trifluoromethyl)quinazolin-4-yl]amino}pyrrolidin-2-one, ... | 著者 | Zheng, Y, Qin, L, Ortiz Zacarias, N.V, de Vries, H, Han, G.W, Gustavsson, M, Dabros, M, Zhao, C, Cherney, R.J, Carter, P, Stamos, D, Abagyan, R, Cherezov, V, Stevens, R.C, IJzerman, A.P, Heitman, L.H, Tebben, A, Kufareva, I, Handel, T.M. | 登録日 | 2016-08-18 | 公開日 | 2016-12-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.806 Å) | 主引用文献 | Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature, 540, 2016
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5T1Y
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5SZY
| Novel Structural Insights into GDP-Mediated Regulation of Acyl-CoA Thioesterases | 分子名称: | Acyl-CoA hydrolase, CHLORIDE ION, COENZYME A, ... | 著者 | Khandokar, Y.B, Srivastava, P, Forwood, J.K. | 登録日 | 2016-08-15 | 公開日 | 2016-09-14 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase. J. Biol. Chem., 292, 2017
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5T1H
| Crystal structure of CK2 | 分子名称: | 1,2-ETHANEDIOL, 7-(cyclopropylamino)-5-[3-(6-oxo-1,6-dihydropyridin-3-yl)thiophen-2-yl]pyrazolo[1,5-a]pyrimidine-3-carbonitrile, Casein kinase II subunit alpha, ... | 著者 | Feguson, A.D. | 登録日 | 2016-08-19 | 公開日 | 2017-11-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Crystal structure of CK2 To Be Published
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5SUS
| X-ray crystallographic structure of a covalent trimer derived from A-beta 17_36. X-ray diffractometer data set. (ORN)CVF(MEA)CED(ORN)AIIGL(ORN)V. | 分子名称: | 16mer A-beta peptide: ORN-CYS-VAL-PHE-MEA-CYS-GLU-ASP-ORN-ALA-ILE-ILE-GLY-LEU-ORN-VAL, CHLORIDE ION, SODIUM ION | 著者 | Kreutzer, A.G, Yoo, S, Nowick, J.S. | 登録日 | 2016-08-03 | 公開日 | 2017-01-11 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.349 Å) | 主引用文献 | Stabilization, Assembly, and Toxicity of Trimers Derived from A beta. J.Am.Chem.Soc., 139, 2017
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5SUT
| X-ray crystallographic structure of a covalent trimer derived from A-beta 17_36. Synchrotron data set. (ORN)CVFFCED(ORN)AII(SAR)L(ORN)V. | 分子名称: | 16mer A-beta peptide: ORN-CYS-VAL-PHE-PHE-CYS-GLU-ASP-ORN-ALA-ILE-ILE-SAR-LEU-ORN-VAL, CHLORIDE ION | 著者 | Kreutzer, A.G, Spencer, R.K, Nowick, J.S. | 登録日 | 2016-08-03 | 公開日 | 2017-01-11 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | 主引用文献 | Stabilization, Assembly, and Toxicity of Trimers Derived from A beta. J.Am.Chem.Soc., 139, 2017
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5T2W
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5T0Y
| 2A10 Antibody FAB fragment | 分子名称: | 2A10 FAB fragment heavy chain, 2A10 FAB fragment light chain, SULFATE ION | 著者 | Jackson, C.J, Fisher, C. | 登録日 | 2016-08-17 | 公開日 | 2017-06-21 | 実験手法 | X-RAY DIFFRACTION (3.011 Å) | 主引用文献 | Restricted antibody diversity and low affinity limit antibody responses to the Plasmodium circumsporozoite protein To Be Published
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5T1U
| Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality | 分子名称: | (4S)-4-[2,4-difluoro-5-({[1-(trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine, 1,2-ETHANEDIOL, Beta-secretase 1, ... | 著者 | Parris, K.D, Vajdos, F. | 登録日 | 2016-08-22 | 公開日 | 2017-01-11 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality. J. Med. Chem., 60, 2017
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5T4Y
| Crystal structure of BT1762-1763 | 分子名称: | MAGNESIUM ION, SusC homolog, SusD homolog | 著者 | van den Berg, B. | 登録日 | 2016-08-30 | 公開日 | 2016-12-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural basis for nutrient acquisition by dominant members of the human gut microbiota. Nature, 541, 2017
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5T2T
| Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease bound to compound L742001 | 分子名称: | (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, CHLORIDE ION, GLYCEROL, ... | 著者 | Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F. | 登録日 | 2016-08-24 | 公開日 | 2017-09-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.967 Å) | 主引用文献 | Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands. IUCrJ, 5, 2018
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5T6C
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5T3Z
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5T7U
| Crystal structure of galectin-8N in complex with Glycerol | 分子名称: | CHLORIDE ION, GLYCEROL, Galectin-8, ... | 著者 | Bohari, M.H, Yu, X, Blanchard, H. | 登録日 | 2016-09-05 | 公開日 | 2017-01-04 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Structure-based rationale for differential recognition of lacto- and neolacto- series glycosphingolipids by the N-terminal domain of human galectin-8. Sci Rep, 6, 2016
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5T6A
| Crystal Structure of TgCDPK1 from toxoplasma gondii complexed with 5GA | 分子名称: | 4-(3-chloro-4-fluorophenyl)-5-(1,5-naphthyridin-2-yl)-1,3-thiazol-2-amine, Calmodulin-domain protein kinase 1 | 著者 | Jiang, D.Q, Tempel, W, Loppnau, P, Walker, J.R, Graslund, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Lovato, D.V, Osman, K.T, Structural Genomics Consortium (SGC) | 登録日 | 2016-09-01 | 公開日 | 2016-11-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal Structure of TgCDPK1 from toxoplasma gondii complexed with SGC-1-9 to be published
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5T84
| HIV-1 protease, unbound subtype B L63P construct | 分子名称: | Protease | 著者 | Liu, Z, Norell, J, Mahon, B, Poole, K, McKenna, R, Fanucci, G. | 登録日 | 2016-09-06 | 公開日 | 2017-09-20 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Single mutation, L63P, capable of shutting down the flaps of HIV-1 protease To Be Published
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5T6I
| CRYSTAL STRUCTURE OF TGCDPK1 FROM TOXOPLASMA GONDII COMPLEXED WITH 5GB | 分子名称: | 4-(3-methylphenyl)-5-(1,5-naphthyridin-2-yl)-1,3-thiazol-2-amine, Calmodulin-domain protein kinase 1 | 著者 | Jiang, D.Q, Tempel, W, Walker, J.R, El Bakkouri, M, Loppnau, P, Graslund, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Lovato, D.V, Osman, K.T, Structural Genomics Consortium (SGC) | 登録日 | 2016-09-01 | 公開日 | 2016-11-02 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Crystal Structure of CDPK1 from toxoplasma gondii complexed with SGC-1-19 to be published
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5T96
| Crystal structure of the infectious salmon anemia virus (ISAV) HE viral receptor complex | 分子名称: | 4-O-acetyl-5-acetamido-3,5-dideoxy-L-glycero-alpha-D-galacto-non-2-ulopyranosonic acid, FORMIC ACID, GLYCEROL, ... | 著者 | Cook, J.D, Sultana, A, Lee, J.E. | 登録日 | 2016-09-09 | 公開日 | 2017-03-22 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the infectious salmon anemia virus receptor complex illustrates a unique binding strategy for attachment. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5TC2
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5TC4
| Crystal structure of human mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase (MTHFD2) in complex with LY345899 and cofactors | 分子名称: | 4-(7-AMINO-9-HYDROXY-1-OXO-3,3A,4,5-TETRAHYDRO-2,5,6,8,9B-PENTAAZA-CYCLOPENTA[A]NAPHTHALEN-2-YL)-PHENYLCARBONYL-GLUTAMI C ACID, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... | 著者 | Gustafsson, R, Jemth, A.-S, Gustafsson Sheppard, N, Farnegardh, K, Loseva, O, Wiita, E, Bonagas, N, Dahllund, L, Llona-Minguez, S, Haggblad, M, Henriksson, M, Andersson, Y, Homan, E, Helleday, T, Stenmark, P. | 登録日 | 2016-09-14 | 公開日 | 2016-12-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor. Cancer Res., 77, 2017
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5TFX
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5TC9
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