5TC4

Crystal structure of human mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase (MTHFD2) in complex with LY345899 and cofactors

Summary for 5TC4

Entry DOI	10.2210/pdb5tc4/pdb
Descriptor	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(7-AMINO-9-HYDROXY-1-OXO-3,3A,4,5-TETRAHYDRO-2,5,6,8,9B-PENTAAZA-CYCLOPENTA[A]NAPHTHALEN-2-YL)-PHENYLCARBONYL-GLUTAMI C ACID, ... (5 entities in total)
Functional Keywords	inhibitor, folate, cofactor, dehydrogenase, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Mitochondrion: P13995
Total number of polymer chains	1
Total formula weight	35544.57
Authors	Gustafsson, R.,Jemth, A.-S.,Gustafsson Sheppard, N.,Farnegardh, K.,Loseva, O.,Wiita, E.,Bonagas, N.,Dahllund, L.,Llona-Minguez, S.,Haggblad, M.,Henriksson, M.,Andersson, Y.,Homan, E.,Helleday, T.,Stenmark, P. (deposition date: 2016-09-14, release date: 2016-12-14, Last modification date: 2024-01-17)
Primary citation	Gustafsson, R.,Jemth, A.S.,Gustafsson, N.M.,Farnegardh, K.,Loseva, O.,Wiita, E.,Bonagas, N.,Dahllund, L.,Llona-Minguez, S.,Haggblad, M.,Henriksson, M.,Andersson, Y.,Homan, E.,Helleday, T.,Stenmark, P. Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor. Cancer Res., 77:937-948, 2017 Cited by PubMed: 27899380 DOI: 10.1158/0008-5472.CAN-16-1476 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation