Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004477 | molecular_function | methenyltetrahydrofolate cyclohydrolase activity |
| A | 0004487 | molecular_function | methylenetetrahydrofolate dehydrogenase (NAD+) activity |
| A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0015943 | biological_process | formate biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0042301 | molecular_function | phosphate ion binding |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
| A | 0046655 | biological_process | folic acid metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | THR176 |
| A | ALA254 |
| A | GLY255 |
| A | ILE256 |
| A | VAL274 |
| A | GLY275 |
| A | ILE276 |
| A | GLY313 |
| A | THR316 |
| A | PO4403 |
| A | HOH537 |
| A | GLY200 |
| A | HOH544 |
| A | HOH560 |
| A | HOH567 |
| A | HOH592 |
| A | HOH622 |
| A | HOH629 |
| A | ARG201 |
| A | SER202 |
| A | ASN204 |
| A | VAL205 |
| A | HIS232 |
| A | ARG233 |
| A | ALA253 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue L34 A 402 |
| Chain | Residue |
| A | TYR84 |
| A | ASN87 |
| A | LYS88 |
| A | VAL131 |
| A | GLN132 |
| A | LEU133 |
| A | ASP155 |
| A | PHE157 |
| A | ILE276 |
| A | ARG278 |
| A | LEU289 |
| A | PRO309 |
| A | GLY310 |
| A | PRO314 |
| A | HOH501 |
| A | HOH515 |
| A | HOH521 |
| A | HOH522 |
| A | HOH530 |
| A | HOH538 |
| A | HOH561 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 A 403 |
| Chain | Residue |
| A | ARG201 |
| A | ARG233 |
| A | NAD401 |
| A | HOH537 |
| A | HOH563 |
Functional Information from PROSITE/UniProt
| site_id | PS00766 |
| Number of Residues | 26 |
| Details | THF_DHG_CYH_1 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 1. EeELLnlInkLNnDdnvdgLLVQLPL |
| Chain | Residue | Details |
| A | GLU110-LEU135 | |
| site_id | PS00767 |
| Number of Residues | 9 |
| Details | THF_DHG_CYH_2 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. PGGVGPMTV |
| Chain | Residue | Details |
| A | PRO309-VAL317 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27899380","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16100107","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27899380","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
