5TC4
Crystal structure of human mitochondrial methylenetetrahydrofolate dehydrogenase-cyclohydrolase (MTHFD2) in complex with LY345899 and cofactors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial | polymer | 316 | 34314.7 | 1 | UniProt (P13995) Pfam (PF00763) Pfam (PF02882) | Homo sapiens (Human) | |
| 2 | B (A) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 3 | C (A) | 4-(7-AMINO-9-HYDROXY-1-OXO-3,3A,4,5-TETRAHYDRO-2,5,6,8,9B-PENTAAZA-CYCLOPENTA[A]NAPHTHALEN-2-YL)-PHENYLCARBONYL-GLUTAMI C ACID | non-polymer | 471.4 | 1 | Chemie (L34) | |||
| 4 | D (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | E (A) | water | water | 18.0 | 214 | Chemie (HOH) |
Sequence modifications
A: 36 - 350 (UniProt: P13995)
| PDB | External Database | Details |
|---|---|---|
| Met 35 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34314.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1229.8 | |
| All* | Total formula weight | 35544.6 |
