PDB: 1553 件ウェブページステータス検索Chemie searchBIRD

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1FQR	X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93I/F95M/W97V CARBONIC ANHYDRASE (CAII) VARIANT 分子名称: CARBONIC ANHYDRASE, COBALT (II) ION 著者 Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. 登録日 2000-09-06 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
1FR7	X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT 分子名称: CARBONIC ANHYDRASE II, ZINC ION 著者 Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. 登録日 2000-09-07 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
7C5W	Crystal structure of the iota-carbonic anhydrase from cyanobacterium complexed with iodide 分子名称: IODIDE ION, iota-carbonic anhydrase 著者 Senda, M, Senda, T. 登録日 2020-05-20 公開日 2021-04-28 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Characterization of a novel type of carbonic anhydrase that acts without metal cofactors. Bmc Biol., 19, 2021
7C5X	Crystal structure of the iota-carbonic anhydrase from eukaryotic microalga complexed with bicarbonate 分子名称: BICARBONATE ION, iota-carbonic anhydrase 著者 Senda, M, Senda, T. 登録日 2020-05-20 公開日 2021-04-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Characterization of a novel type of carbonic anhydrase that acts without metal cofactors. Bmc Biol., 19, 2021
7C5V	Crystal structure of the iota-carbonic anhydrase from cyanobacterium complexed with bicarbonate 分子名称: BICARBONATE ION, iota-carbonic anhydrase 著者 Senda, M, Senda, T. 登録日 2020-05-20 公開日 2021-04-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Characterization of a novel type of carbonic anhydrase that acts without metal cofactors. Bmc Biol., 19, 2021
7C5Y	Crystal structure of the iota-carbonic anhydrase from eukaryotic microalga complexed with iodide 分子名称: IODIDE ION, iota-carbonic anhydrase 著者 Senda, M, Senda, T. 登録日 2020-05-20 公開日 2021-04-28 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Characterization of a novel type of carbonic anhydrase that acts without metal cofactors. Bmc Biol., 19, 2021
6YJN	Crystal structure of beta carbonic anhydrase from the pathogenic bacterium Burkholderia pseudomallei. 分子名称: Beta carbonic anhydrase, ZINC ION 著者 Angeli, A, Ferraroni, M. 登録日 2020-04-03 公開日 2020-06-10 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal Structure of a Tetrameric Type II beta-Carbonic Anhydrase from the Pathogenic BacteriumBurkholderia pseudomallei. Molecules, 25, 2020
5UMC	Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography 分子名称: Carbonic anhydrase 2, GLYCEROL, UNKNOWN LIGAND, ... 著者 Peat, T.S, Angeli, A, Tanini, D, Bartolucci, G, Capperucci, A, Supuran, C.T, Carta, F. 登録日 2017-01-26 公開日 2017-12-06 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors. ACS Med Chem Lett, 8, 2017
2AX2	Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II 分子名称: Carbonic anhydrase II, ZINC ION 著者 Budayova-Spano, M, Fisher, S.Z, Dauvergne, M.T, Silverman, D.N, Myles, D.A.A, McKenna, R.M. 登録日 2005-09-02 公開日 2006-01-03 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II. Acta Crystallogr.,Sect.F, 62, 2006
5WLV	Carbonic Anhydrase II in complex with aryloxy-2-hydroxypropylammine sulfonamide 分子名称: 4-{(2R)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}-N-[2-(4-sulfamoylphenyl)ethyl]benzamide, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Lomelino, C.L, Andring, J.T, McKenna, R. 登録日 2017-07-27 公開日 2018-08-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Discovery of beta-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy. J. Med. Chem., 61, 2018
2NWO	Structural and kinetic effect of hydrophobic mutations in the active site of human carbonic anhydrase II 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Fisher, S.Z, McKenna, R. 登録日 2006-11-16 公開日 2007-04-24 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Speeding Up Proton Transfer in a Fast Enzyme: Kinetic and Crystallographic Studies on the Effect of Hydrophobic Amino Acid Substitutions in the Active Site of Human Carbonic Anhydrase II. Biochemistry, 46, 2007
5WLT	Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide 分子名称: 4-{(2S)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}benzene-1-sulfonamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Lomelino, C.L, Andring, J.T, McKenna, R. 登録日 2017-07-27 公開日 2018-08-01 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Discovery of beta-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy. J. Med. Chem., 61, 2018
2NNV	Structure of inhibitor binding to Carbonic Anhydrase II 分子名称: Carbonic anhydrase 2, ETHYL 3-[4-(AMINOSULFONYL)PHENYL]PROPANOATE, GLYCEROL, ... 著者 Christianson, D.W, Jude, K.M. 登録日 2006-10-24 公開日 2007-05-08 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Structural Analysis of Charge Discrimination in the Binding of Inhibitors to Human Carbonic Anhydrases I and II. J.Am.Chem.Soc., 129, 2007
1FSN	X-RAY CRYSTAL STRUCTURE OF METAL-FREE F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT 分子名称: CARBONIC ANHYDRASE II 著者 Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. 登録日 2000-09-11 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
1FSR	X-RAY CRYSTAL STRUCTURE OF COPPER-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT 分子名称: CARBONIC ANHYDRASE II, COPPER (II) ION 著者 Cox, J.D, Hunt, J.A, Compher, K.M, Fierke, C.A, Christianson, D.W. 登録日 2000-09-11 公開日 2001-01-17 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II. Biochemistry, 39, 2000
6OE0	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects 分子名称: 2-(2,4-dioxo-1,3-diazaspiro[4.6]undecan-3-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Peat, T.S. 登録日 2019-03-27 公開日 2019-06-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur.J.Med.Chem., 177, 2019
6ODZ	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects 分子名称: 2-(2,4-dioxo-1,3-diazaspiro[4.4]nonan-3-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Peat, T.S. 登録日 2019-03-27 公開日 2019-06-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur.J.Med.Chem., 177, 2019
6GDC	Human Carbonic Anhydrase II in complex with Benzenesulfonamide 分子名称: Carbonic anhydrase 2, MERCURIBENZOIC ACID, MERCURY (II) ION, ... 著者 Gloeckner, S, Heine, A, Klebe, G. 登録日 2018-04-23 公開日 2019-05-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.079 Å) 主引用文献 Conformational Changes in Alkyl Chains Determine the Thermodynamic and Kinetic Binding Profiles of Carbonic Anhydrase Inhibitors. Acs Chem.Biol., 15, 2020
5A6H	Synthesis, carbonic anhydrase inhibition and protein X-ray structure of the unusual natural product primary sulfonamide Psammaplin C 分子名称: CARBONIC ANHYDRASE 2, DIMETHYL SULFOXIDE, PSAMMAPLIN C, ... 著者 Mujumdar, P, Supuran, C.T, Peat, T.S, Poulsen, S. 登録日 2015-06-26 公開日 2016-05-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition and Protein X-Ray Structures of Psammaplin C. J.Med.Chem., 59, 2016
4YWP	Sucrose Binding Site in genetically engineered Carbonic anhydrase IX 分子名称: Carbonic anhydrase 2, ZINC ION, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose 著者 Pinard, M.A, Aggarwal, M. 登録日 2015-03-20 公開日 2015-10-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX. Acta Crystallogr F Struct Biol Commun, 71, 2015
6G3Q	Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION, ... 著者 Ferraroni, M, Supuran, C.T, Angeli, A. 登録日 2018-03-26 公開日 2018-11-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.01 Å) 主引用文献 Famotidine, an Antiulcer Agent, Strongly InhibitsHelicobacter pyloriand Human Carbonic Anhydrases. ACS Med Chem Lett, 9, 2018
6OE1	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects 分子名称: 2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)-N-(4-sulfamoylphenyl)acetamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Peat, T.S. 登録日 2019-03-27 公開日 2019-06-12 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur.J.Med.Chem., 177, 2019
6G3V	Crystal structure of human carbonic anhydrase I in complex with the inhibitor famotidine 分子名称: Carbonic anhydrase 1, GLYCEROL, ZINC ION, ... 著者 Ferraroni, M, Supuran, C.T, Angeli, A. 登録日 2018-03-26 公開日 2018-11-28 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Famotidine, an Antiulcer Agent, Strongly InhibitsHelicobacter pyloriand Human Carbonic Anhydrases. ACS Med Chem Lett, 9, 2018
1OKL	CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKL INHIBITOR 5-DIMETHYLAMINO-NAPHTHALENE-1-SULFONAMIDE 分子名称: 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONAMIDE, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... 著者 Nair, S.K, Elbaum, D, Christianson, D.W. 登録日 1996-06-25 公開日 1997-01-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Unexpected binding mode of the sulfonamide fluorophore 5-dimethylamino-1-naphthalene sulfonamide to human carbonic anhydrase II. Implications for the development of a zinc biosensor. J.Biol.Chem., 271, 1996
4ZWZ	Engineered Carbonic Anhydrase IX mimic in complex with a glucosyl sulfamate inhibitor 分子名称: Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ZINC ION, ... 著者 Mahon, B.P, Lomelino, C.L, Driscoll, J.M, McKenna, R. 登録日 2015-05-19 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates. J.Med.Chem., 58, 2015

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