6UFB

Carbonic anhydrase 2 with inhibitor (2Z)-2-benzylidene-3-oxo-N-(4-sulfamoylphenyl)butanamide (11a/D1)

Summary for 6UFB

Entry DOI	10.2210/pdb6ufb/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (7 entities in total)
Functional Keywords	carbonic anhydrase, inhibitor, complex, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	30014.56
Authors	Peat, T.S. (deposition date: 2019-09-24, release date: 2020-08-05, Last modification date: 2023-10-11)
Primary citation	Fares, M.,Eldehna, W.M.,Bua, S.,Lanzi, C.,Lucarini, L.,Masini, E.,Peat, T.S.,Abdel-Aziz, H.A.,Nocentini, A.,Keller, P.A.,Supuran, C.T. Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action. J.Med.Chem., 63:3317-3326, 2020 Cited by PubMed: 32031797 DOI: 10.1021/acs.jmedchem.9b02090 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.67 Å)

Structure validation