4G0C

Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding.

Summary for 4G0C

Entry DOI	10.2210/pdb4g0c/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ... (4 entities in total)
Functional Keywords	carbonic anhydrase, acetazolamide, hydrogen bonding, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29220.29
Authors	Fisher, S.Z.,McKenna, R.,Aggarwal, M. (deposition date: 2012-07-09, release date: 2012-09-19, Last modification date: 2023-09-13)
Primary citation	Fisher, S.Z.,Aggarwal, M.,Kovalevsky, A.Y.,Silverman, D.N.,McKenna, R. Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding. J.Am.Chem.Soc., 134:14726-14729, 2012 Cited by PubMed: 22928733 DOI: 10.1021/ja3068098 PDB entries with the same primary citation
Experimental method	NEUTRON DIFFRACTION (2 Å)

Structure validation