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3A1L
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Crystal Structure of 11,11'-Dichlorochromopyrrolic Acid Bound Cytochrome P450 StaP (CYP245A1)
分子名称: 3,4-bis(7-chloro-1H-indol-3-yl)-1H-pyrrole-2,5-dicarboxylic acid, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE
著者Makino, M, Sugimoto, H, Shiro, Y, Asamizu, S, Onaka, H, Nagano, S.
登録日2009-04-09
公開日2009-05-12
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Theoretical and experimental studies of the conversion of chromopyrrolic acid to an antitumor derivative by cytochrome P450 StaP: the catalytic role of water molecules
J.Am.Chem.Soc., 131, 2009
3G5N
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BU of 3g5n by Molmil
Triple ligand occupancy crystal structure of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole
分子名称: 1-(biphenyl-4-ylmethyl)-1H-imidazole, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2B4, ...
著者Gay, S.C, Sun, L, Maekawa, K, Halpert, J.R, Stout, C.D.
登録日2009-02-05
公開日2009-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Biochemistry, 48, 2009
3G93
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Single ligand occupancy crystal structure of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole
分子名称: 1-(biphenyl-4-ylmethyl)-1H-imidazole, Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE
著者Gay, S.C, Sun, L, Maekawa, K, Halpert, J.R, Stout, C.D.
登録日2009-02-12
公開日2009-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning.
Biochemistry, 48, 2009
3DBG
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BU of 3dbg by Molmil
Crystal structure of Cytochrome P450 170A1 (CYP170A1) from Streptomyces coelicolor
分子名称: PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450
著者Zhao, B, Vassylyev, D.G, Waterman, M.R.
登録日2008-05-31
公開日2009-06-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site
J.Biol.Chem., 284, 2009
3DGI
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BU of 3dgi by Molmil
Crystal structure of F87A/T268A mutant of CYP BM3
分子名称: Bifunctional P-450/NADPH-P450 reductase, DIMETHYL SULFOXIDE, PROTOPORPHYRIN IX CONTAINING FE
著者Le Trong, I, Katayama, J.H, Totah, R.A, Stenkamp, R.E, Fox, E.P.
登録日2008-06-13
公開日2009-06-16
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Homolytic versus heterolytic dioxygen bond cleavage in cytochrome P450 BM3.
To be Published
3HF2
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Crystal structure of the I401P mutant of cytochrome P450 BM3
分子名称: Bifunctional P-450/NADPH-P450 reductase, PROTOPORPHYRIN IX CONTAINING FE
著者Yang, W, Whitehouse, C.J.C, Bell, S.G, Bartlam, M, Wong, L.L, Rao, Z.
登録日2009-05-10
公開日2009-06-30
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献A Highly Active Single-Mutation Variant of P450(BM3) (CYP102A1)
Chembiochem, 10, 2009
2JJO
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Structure of cytochrome P450 EryK in complex with its natural substrate erD
分子名称: CYTOCHROME P450 113A1, Erythromycin D, PROTOPORPHYRIN IX CONTAINING FE
著者Savino, C, Sciara, G, Miele, A.E, Kendrew, S.G, Vallone, B.
登録日2008-04-15
公開日2009-07-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Investigating the Structural Plasticity of a Cytochrome P450: Three-Dimensional Structures of P450 Eryk and Binding to its Physiological Substrate.
J.Biol.Chem., 284, 2009
2JJN
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Structure of closed cytochrome P450 EryK
分子名称: CYTOCHROME P450 113A1, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
著者Savino, C, Sciara, G, Miele, A.E, Kendrew, S.G, Vallone, B.
登録日2008-04-15
公開日2009-07-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Investigating the Structural Plasticity of a Cytochrome P450: Three-Dimensional Structures of P450 Eryk and Binding to its Physiological Substrate.
J.Biol.Chem., 284, 2009
2JJP
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Structure of cytochrome P450 EryK in complex with inhibitor ketoconazole (KC)
分子名称: 1-ACETYL-4-(4-{[(2S,4R)-2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY}PHENYL)PIPERAZINE, CYTOCHROME P450 113A1, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Savino, C, Sciara, G, Miele, A.E, Kendrew, S.G, Vallone, B.
登録日2008-04-15
公開日2009-07-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Azole Drugs Trap Cytochrome P450 Eryk in Alternative Conformational States.
Biochemistry, 49, 2010
2WH8
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Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines
分子名称: 5-AMINO-2-{4-[(4-AMINOPHENYL)SULFANYL]PHENYL}-1H-ISOINDOLE-1,3(2H)-DIONE, PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 130
著者Podust, L.M, Ouellet, H, von Kries, J.P, Ortiz de Montellano, P.R.
登録日2009-05-01
公開日2009-07-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines.
J. Biol. Chem., 284, 2009
2WHF
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Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines
分子名称: 1-(3-METHYLPHENYL)-1H-BENZIMIDAZOL-5-AMINE, PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 130
著者Podust, L.M, Ouellet, H, von Kries, J.P, Ortiz de Montellano, P.R.
登録日2009-05-04
公開日2009-07-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Interaction of Mycobacterium tuberculosis CYP130 with heterocyclic arylamines.
J. Biol. Chem., 284, 2009
2WIO
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Structure of the histidine tagged, open cytochrome P450 Eryk from S. erythraea
分子名称: ERYTHROMYCIN B/D C-12 HYDROXYLASE, PROTOPORPHYRIN IX CONTAINING FE
著者Savino, C, Montemiglio, L.C, Sciara, G, Miele, A.E, Kedrew, S.G, Gianni, S, Vallone, B.
登録日2009-05-14
公開日2009-07-21
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Investigating the Structural Plasticity of a Cytochrome P450: Three-Dimensional Structures of P450 Eryk and Binding to its Physiological Substrate.
J.Biol.Chem., 284, 2009
2WIV
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Cytochrome-P450 XplA heme domain P21
分子名称: CYTOCHROME P450-LIKE PROTEIN XPLA, PROTOPORPHYRIN IX CONTAINING FE
著者Sabbadin, F, Jackson, R, Bruce, N.C, Grogan, G.
登録日2009-05-18
公開日2009-08-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The 1.5-A Structure of Xpla-Heme, an Unusual Cytochrome P450 Heme Domain that Catalyzes Reductive Biotransformation of Royal Demolition Explosive.
J.Biol.Chem., 284, 2009
2WIY
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Cytochrome P450 XplA heme domain P21212
分子名称: 1,2-ETHANEDIOL, CYTOCHROME P450-LIKE PROTEIN XPLA, IMIDAZOLE, ...
著者Sabbadin, F, Jackson, R, Bruce, N.C, Grogan, G.
登録日2009-05-18
公開日2009-08-18
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献The 1.5-A Structure of Xpla-Heme, an Unusual Cytochrome P450 Heme Domain that Catalyzes Reductive Biotransformation of Royal Demolition Explosive.
J.Biol.Chem., 284, 2009
2ZQX
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Cytochrome P450BSbeta cocrystallized with heptanoic acid
分子名称: Cytochrome P450 152A1, PROTOPORPHYRIN IX CONTAINING FE
著者Shoji, O, Fujishiro, T, Nagano, S, Hirose, T, Shiro, Y, Watanabe, Y.
登録日2008-08-22
公開日2009-08-25
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Understanding substrate misrecognition of hydrogen peroxide dependent cytochrome P450 from Bacillus subtilis.
J.Biol.Inorg.Chem., 2010
2ZQJ
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Substrate-Free Form of Cytochrome P450BSbeta
分子名称: Cytochrome P450 152A1, PROTOPORPHYRIN IX CONTAINING FE
著者Shoji, O, Fujishiro, T, Nagano, S, Hirose, T, Shiro, Y, Watanabe, Y.
登録日2008-08-11
公開日2009-09-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Understanding substrate misrecognition of hydrogen peroxide dependent cytochrome P450 from Bacillus subtilis.
J.Biol.Inorg.Chem., 2010
3EL3
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Distinct Monooxygenase and Farnesene Synthase Active Sites in Cytochrome P450 170A1
分子名称: (3S,3aR,6S)-3,7,7,8-tetramethyl-2,3,4,5,6,7-hexahydro-1H-3a,6-methanoazulene, PROTOPORPHYRIN IX CONTAINING FE, Putative cytochrome P450
著者Zhao, B, Waterman, M.R.
登録日2008-09-19
公開日2009-09-29
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site
J.Biol.Chem., 284, 2009
2WM4
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X-ray structure of Mycobacterium tuberculosis cytochrome P450 CYP124 in complex with phytanic acid
分子名称: (3R,7S,11S)-3,7,11,15-tetramethylhexadecanoic acid, CALCIUM ION, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Johnston, J.B, Kells, P.M, Podust, L.M, Ortiz de Montellano, P.R.
登録日2009-06-30
公開日2009-10-06
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis.
Proc. Natl. Acad. Sci. U.S.A., 106, 2009
2WM5
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X-ray structure of the substrate-free Mycobacterium tuberculosis cytochrome P450 CYP124
分子名称: PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 124
著者Johnston, J.B, Kells, P.M, Podust, L.M, Ortiz de Montellano, P.R.
登録日2009-06-30
公開日2009-10-06
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis.
Proc. Natl. Acad. Sci. U.S.A., 106, 2009
3G1Q
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Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in ligand free state
分子名称: PROTOPORPHYRIN IX CONTAINING FE, Sterol 14-alpha-demethylase
著者Lepesheva, G.I, Hargrove, T.Y, Harp, J, Wawrzak, Z, Waterman, M.R, Park, H.
登録日2009-01-30
公開日2009-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
J.Biol.Chem., 285, 2010
2ZUI
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Crystal Structure of Camphor-soaked Ferric Cytochrome P450cam Mutant (D297N)
分子名称: CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ...
著者Sakurai, K, Harada, K, Shimada, H, Shimokata, K, Hayashi, T, Tsukihara, T.
登録日2008-10-18
公開日2009-10-20
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure of Camphor-soaked Ferric Cytochrome P450cam Mutant
TO BE PUBLISHED
2ZUJ
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Crystal Structure of Camphor-soaked Ferric Cytochrome P450cam Mutant(D297L)
分子名称: CAMPHOR, Camphor 5-monooxygenase, POTASSIUM ION, ...
著者Sakurai, K, Harada, K, Shimada, H, Shimokata, K, Hayashi, T, Tsukihara, T.
登録日2008-10-18
公開日2009-10-20
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of Camphor-soaked Ferric Cytochrome P450cam Mutant
to be published
2ZUH
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Crystal Structure of Camphor-soaked Ferric Cytochrome P450cam Mutant (D297A)
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CAMPHOR, Camphor 5-monooxygenase, ...
著者Sakurai, K, Harada, K, Shimada, H, Shimokata, K, Hayashi, T, Tsukihara, T.
登録日2008-10-18
公開日2009-10-20
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal Structure of Camphor-soaked Ferric Cytochrome P450cam Mutant
to be published
2WUZ
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X-ray structure of CYP51 from Trypanosoma cruzi in complex with fluconazole in alternative conformation
分子名称: 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, LANOSTEROL 14-ALPHA-DEMETHYLASE, PUTATIVE, ...
著者Chen, C.-K, Leung, S.S.F, Guilbert, C, Jacobson, M, McKerrow, J.H, Podust, L.M.
登録日2009-10-11
公開日2009-10-20
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural Characterization of Cyp51 from Trypanosoma Cruzi and Trypanosoma Brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole
Plos Negl Trop Dis, 4, 2010
3K1O
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Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma cruzi in complex with a potential antichagasic drug, posaconazole
分子名称: 2,5-anhydro-1,3,4-trideoxy-2-(2,4-difluorophenyl)-6-O-{4-[4-(4-{1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenyl}-1-(1H-1,2,4-triazol-1-yl)-D-erythro-hexitol, PROTOPORPHYRIN IX CONTAINING FE, Sterol 14 alpha-demethylase
著者Lepesheva, G.I, Hargrove, T.Y, Anderson, S, Wawrzak, Z, Waterman, M.R.
登録日2009-09-28
公開日2009-10-27
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Structural Insights into Inhibition of Sterol 14{alpha}-Demethylase in the Human Pathogen Trypanosoma cruzi.
J.Biol.Chem., 285, 2010

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