3G1Q

Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in ligand free state

Summary for 3G1Q

Entry DOI	10.2210/pdb3g1q/pdb
Descriptor	Sterol 14-alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total)
Functional Keywords	sterol 14-alpha demethylase, cyp51, cytochrome p450, heme, oxidoreductase, monooxygenase, membrane protein, sterol biosynthesis
Biological source	Trypanosoma brucei
Total number of polymer chains	4
Total formula weight	206370.56
Authors	Lepesheva, G.I.,Hargrove, T.Y.,Harp, J.,Wawrzak, Z.,Waterman, M.R.,Park, H. (deposition date: 2009-01-30, release date: 2009-10-06, Last modification date: 2023-09-06)
Primary citation	Lepesheva, G.I.,Park, H.W.,Hargrove, T.Y.,Vanhollebeke, B.,Wawrzak, Z.,Harp, J.M.,Sundaramoorthy, M.,Nes, W.D.,Pays, E.,Chaudhuri, M.,Villalta, F.,Waterman, M.R. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J.Biol.Chem., 285:1773-1780, 2010 Cited by PubMed: 19923211 DOI: 10.1074/jbc.M109.067470 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation