3G1Q
Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in ligand free state
Summary for 3G1Q
Entry DOI | 10.2210/pdb3g1q/pdb |
Descriptor | Sterol 14-alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE (3 entities in total) |
Functional Keywords | sterol 14-alpha demethylase, cyp51, cytochrome p450, heme, oxidoreductase, monooxygenase, membrane protein, sterol biosynthesis |
Biological source | Trypanosoma brucei |
Total number of polymer chains | 4 |
Total formula weight | 206370.56 |
Authors | Lepesheva, G.I.,Hargrove, T.Y.,Harp, J.,Wawrzak, Z.,Waterman, M.R.,Park, H. (deposition date: 2009-01-30, release date: 2009-10-06, Last modification date: 2023-09-06) |
Primary citation | Lepesheva, G.I.,Park, H.W.,Hargrove, T.Y.,Vanhollebeke, B.,Wawrzak, Z.,Harp, J.M.,Sundaramoorthy, M.,Nes, W.D.,Pays, E.,Chaudhuri, M.,Villalta, F.,Waterman, M.R. Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections. J.Biol.Chem., 285:1773-1780, 2010 Cited by PubMed: 19923211DOI: 10.1074/jbc.M109.067470 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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