3G1Q
Crystal structure of sterol 14-alpha demethylase (CYP51) from Trypanosoma brucei in ligand free state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Sterol 14-alpha-demethylase | polymer | 450 | 50976.2 | 4 | UniProt (Q385E8) Pfam (PF00067) | Trypanosoma brucei | CYP51 |
| 2 | E, F, G, H (A, B, C, D) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 4 | Chemie (HEM) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 494 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 27 - 476 (UniProt: Q385E8)
| PDB | External Database | Details |
|---|---|---|
| Ser 27 | Thr 27 | engineered mutation |
| Lys 28 | Arg 28 | engineered mutation |
| Gly 29 | Pro 29 | engineered mutation |
| Lys 30 | Thr 30 | engineered mutation |
| Leu 31 | Asp 31 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 203904.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2465.9 | |
| All* | Total formula weight | 206370.6 |
