2WUZ

X-ray structure of CYP51 from Trypanosoma cruzi in complex with fluconazole in alternative conformation

Summary for 2WUZ

Related2WX2 2WV2
DescriptorLANOSTEROL 14-ALPHA-DEMETHYLASE, PUTATIVE, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total)
Functional Keywordsoxidoreductase, methyltransferase, p450, iron, cyp51, metal-binding, ergosterol biosynthesis
Biological sourceTRYPANOSOMA CRUZI
Total number of polymer chains2
Total molecular weight110087.05
Authors
Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,McKerrow, J.H.,Podust, L.M. (deposition date: 2009-10-11, release date: 2009-10-20, Last modification date: 2012-04-11)
Primary citation
Chen, C.-K.,Leung, S.S.F.,Guilbert, C.,Jacobson, M.,Mckerrow, J.H.,Podust, L.M.
Structural Characterization of Cyp51 from Trypanosoma Cruzi and Trypanosoma Brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole
Plos Negl Trop Dis, 4:E651-, 2010
PubMed: 20386598 (PDB entries with the same primary citation)
DOI: 10.1371/JOURNAL.PNTD.0000651
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.35 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.28413 1.2% 5.7% 2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
169117
PDB entries from 2020-09-23