3G5N
Triple ligand occupancy crystal structure of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole
Summary for 3G5N
Entry DOI | 10.2210/pdb3g5n/pdb |
Related | 1PO5 1SUO 2BDM 2Q6N |
Descriptor | Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, 1-(biphenyl-4-ylmethyl)-1H-imidazole, ... (5 entities in total) |
Functional Keywords | p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4, cyp lm2, endoplasmic reticulum, heme, iron, membrane, metal-binding, microsome, phosphoprotein, polymorphism |
Biological source | Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits) |
Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: P00178 |
Total number of polymer chains | 4 |
Total formula weight | 223932.12 |
Authors | Gay, S.C.,Sun, L.,Maekawa, K.,Halpert, J.R.,Stout, C.D. (deposition date: 2009-02-05, release date: 2009-05-12, Last modification date: 2023-09-06) |
Primary citation | Gay, S.C.,Sun, L.,Maekawa, K.,Halpert, J.R.,Stout, C.D. Crystal structures of cytochrome P450 2B4 in complex with the inhibitor 1-biphenyl-4-methyl-1H-imidazole: ligand-induced structural response through alpha-helical repositioning. Biochemistry, 48:4762-4771, 2009 Cited by PubMed: 19397311DOI: 10.1021/bi9003765 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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