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1Z6E
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Factor XA in complex with the inhibitor 1-(3'-amino-1,2-benzisoxazol-5'-yl)-n-(4-(2'-((dimethylamino)methyl)-1h-imidazol-1-yl)-2-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazole-5-carboxamide (razaxaban; DPC906; BMS-561389)
分子名称: 1-(3-AMINO-1,2-BENZISOXAZOL-5-YL)-N-(4-{2-[(DIMETHYLAMINO)METHYL]-1H-IMIDAZOL-1-YL}-2-FLUOROPHENYL)-3-(TRIFLUOROMETHYL) -1H-PYRAZOLE-5-CARBOXAMIDE, Coagulation factor X
著者Alexander, R.S.
登録日2005-03-22
公開日2006-03-28
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Discovery of 1-(3'-aminobenzisoxazol-5'-yl)-3-trifluoromethyl-N-[2-fluoro-4-[(2'-dimethylaminomethyl)imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor.
J.Med.Chem., 48, 2005
1Z6F
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Crystal structure of penicillin-binding protein 5 from E. coli in complex with a boronic acid inhibitor
分子名称: GLYCEROL, N1-[(1R)-1-(DIHYDROXYBORYL)ETHYL]-N2-[(TERT-BUTOXYCARBONYL)-D-GAMMA-GLUTAMYL]-N6-[(BENZYLOXY)CARBONYL-L-LYSINAMIDE, Penicillin-binding protein 5
著者Nicola, G, Peddi, S, Stefanova, M, Nicholas, R.A, Gutheil, W.G, Davies, C.
登録日2005-03-22
公開日2005-06-21
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of Escherichia coli Penicillin-Binding Protein 5 Bound to a Tripeptide Boronic Acid Inhibitor: A Role for Ser-110 in Deacylation.
Biochemistry, 44, 2005
1Z6G
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Crystal structure of guanylate kinase from Plasmodium falciparum
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SULFATE ION, guanylate kinase
著者Mulichak, A.M, Lew, J, Artz, J, Choe, J, Walker, J.R, Zhao, Y, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Hui, R, Gao, M, Structural Genomics Consortium (SGC)
登録日2005-03-22
公開日2005-04-05
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.
Mol.Biochem.Parasitol., 151, 2007
1Z6H
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Solution Structure of Bacillus subtilis BLAP biotinylated-form
分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Biotin/Lipoyl Attachment Protein
著者Cui, G, Xia, B.
登録日2005-03-22
公開日2006-03-22
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献Identification and solution structures of a single domain biotin/lipoyl attachment protein from Bacillus subtilis
J.Biol.Chem., 281, 2006
1Z6I
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Crystal structure of the ectodomain of Drosophila transmembrane receptor PGRP-LCa
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Peptidoglycan-recognition protein-LC, SULFATE ION
著者Chang, C.-I, Ihara, K, Chelliah, Y, Mengin-Lecreulx, D, Wakatsuki, S, Deisenhofer, J.
登録日2005-03-22
公開日2005-07-19
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition
Proc.Natl.Acad.Sci.Usa, 102, 2005
1Z6J
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Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor
分子名称: 5-[AMINO(IMINO)METHYL]-2-[({[6-[3-AMINO-5-({[(1R)-1-METHYLPROPYL]AMINO}CARBONYL)PHENYL]-3-(ISOPROPYLAMINO)-2-OXOPYRAZIN-1(2H)-YL]ACETYL}AMINO)METHYL]-N-PYRIDIN-4-YLBENZAMIDE, CALCIUM ION, Coagulation factor VII, ...
著者Schweitzer, B.A, Neumann, W.L, Rahman, H.K, Kusturin, C.L, Sample, K.R, Poda, G.I, Kurumbail, R.G, Stevens, A.M, Stegeman, R.A, Stallings, W.C.
登録日2005-03-22
公開日2005-05-03
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa.
Bioorg.Med.Chem.Lett., 15, 2005
1Z6K
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Citrate lyase beta subunit complexed with oxaloacetate and magnesium from M. tuberculosis
分子名称: Citrate Lyase beta subunit, MAGNESIUM ION, OXALOACETATE ION
著者Goulding, C.W, Bowers, P.M, Segelke, B, Lekin, T, Kim, C.Y, Terwilliger, T.C, Eisenberg, D, TB Structural Genomics Consortium (TBSGC)
登録日2005-03-22
公開日2005-05-03
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structure and computational analysis of Mycobacterium tuberculosis protein CitE suggest a novel enzymatic function.
J.Mol.Biol., 365, 2007
1Z6L
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crystal structure of Fms1 in complex with its substrate
分子名称: FLAVIN-ADENINE DINUCLEOTIDE, N-(6-AMINOHEXYL)HEXANE-1,6-DIAMINE, Polyamine oxidase FMS1
著者Huang, Q, Liu, Q, Hao, Q.
登録日2005-03-22
公開日2005-09-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献crystal structure of Fms1 in complex with its substrate
To be Published
1Z6M
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Structure of Conserved Protein of Unknown Function from Enterococcus faecalis V583
分子名称: PHOSPHATE ION, conserved hypothetical protein
著者Nocek, B.P, Li, H, Collart, F, Joachimiak, A, MCSG, Midwest Center for Structural Genomics (MCSG)
登録日2005-03-22
公開日2005-05-03
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structure of a conserved hypothetical protein from Enterococcus faecalis V583
To be Published
1Z6N
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1.5 A Crystal Structure of a Protein of Unknown Function PA1234 from Pseudomonas aeruginosa
分子名称: MAGNESIUM ION, hypothetical protein PA1234
著者Zhang, R, Xu, L, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
登録日2005-03-22
公開日2005-05-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献1.5A crystal structure of a hypothetical protein PA1234 from Pseudomonas aeruginosa
To be Published
1Z6O
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Crystal Structure of Trichoplusia ni secreted ferritin
分子名称: CALCIUM ION, FE (III) ION, Ferritin heavy chain, ...
著者Hamburger, A.E, West Jr, A.P, Hamburger, Z.A, Hamburger, P, Bjorkman, P.J.
登録日2005-03-22
公開日2005-05-24
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains.
J.Mol.Biol., 349, 2005
1Z6P
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Glycogen phosphorylase AMP site inhibitor complex
分子名称: 4-{2-[(3-NITROBENZOYL)AMINO]PHENOXY}PHTHALIC ACID, Glycogen phosphorylase, muscle form
著者Kristiansen, M, Andersen, B, Iversen, L.F, Westergaard, N.
登録日2005-03-23
公開日2005-04-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Identification, synthesis and chracterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site
J.Med.Chem., 47, 2004
1Z6Q
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Glycogen phosphorylase with inhibitor in the AMP site
分子名称: 4-{2,4-BIS[(3-NITROBENZOYL)AMINO]PHENOXY}PHTHALIC ACID, Glycogen phosphorylase, muscle form
著者Kristiansen, M, Andersen, B, Iversen, L.F, Westergaard, N.
登録日2005-03-23
公開日2005-04-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Identification, synthesis and chracterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site
J.Med.Chem., 47, 2004
1Z6R
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Crystal structure of Mlc from Escherichia coli
分子名称: Mlc protein, ZINC ION
著者Schiefner, A, Gerber, K, Seitz, S, Welte, W, Diederichs, K, Boos, W.
登録日2005-03-23
公開日2005-06-14
最終更新日2021-11-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The crystal structure of Mlc, a global regulator of sugar metabolism in Escherichia coli
J.Biol.Chem., 280, 2005
1Z6S
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Ribonuclease A- AMP complex
分子名称: ADENOSINE MONOPHOSPHATE, Ribonuclease pancreatic
著者Hatzopoulos, G.N, Leonidas, D.D, Kardakaris, R, Kobe, J, Oikonomakos, N.G.
登録日2005-03-23
公開日2005-08-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献The binding of IMP to Ribonuclease A
Febs J., 272, 2005
1Z6T
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Structure of the apoptotic protease-activating factor 1 bound to ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Apoptotic protease activating factor 1
著者Riedl, S.J, Li, W, Chao, Y, Schwarzenbacher, R, Shi, Y.
登録日2005-03-23
公開日2005-04-19
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structure of the apoptotic protease-activating factor 1 bound to ADP
Nature, 434, 2005
1Z6U
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Np95-like ring finger protein isoform b [Homo sapiens]
分子名称: Np95-like ring finger protein isoform b, ZINC ION
著者Walker, J.R, Avvakumov, G.V, Xue, S, Newman, E.M, Mackenzie, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
登録日2005-03-23
公開日2005-05-03
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献2.1 Angstrom Crystal Structure of the Human Ubiquitin Liagse NIRF
To be Published
1Z6V
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Human lactoferricin
分子名称: Lactotransferrin
著者Hunter, H.N, Demcoe, A.R, Jenssen, H, Gutteberg, T.J, Vogel, H.J.
登録日2005-03-23
公開日2005-08-16
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent
ANTIMICROB.AGENTS CHEMOTHER., 49, 2005
1Z6W
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Human Lactoferricin
分子名称: Lactotransferrin
著者Hunter, H.N, Demcoe, A.R, Jenssen, H, Gutteberg, T.J, Vogel, H.J.
登録日2005-03-23
公開日2005-08-16
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献Human Lactoferricin Is Partially Folded in Aqueous Solution and Is Better Stabilized in a Membrane Mimetic Solvent
ANTIMICROB.AGENTS CHEMOTHER., 49, 2005
1Z6X
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Structure Of Human ADP-Ribosylation Factor 4
分子名称: ADP-ribosylation factor 4, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
著者Choe, J, Atanassova, A, Arrowsmith, C, Edwards, A, Sundstrom, M, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2005-03-23
公開日2005-04-12
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure Of Human ADP-Ribosylation Factor 4
To be Published
1Z6Y
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Structure Of Human ADP-Ribosylation Factor-Like 5
分子名称: ADP-ribosylation factor-like protein 5, GUANOSINE-5'-DIPHOSPHATE
著者Choe, J, Atanassova, A, Arrowsmith, C, Edwards, A, Sundstrom, M, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC)
登録日2005-03-23
公開日2005-04-05
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure Of Human ADP-Ribosylation Factor-Like 5
To be Published
1Z6Z
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Crystal Structure of Human Sepiapterin Reductase in complex with NADP+
分子名称: CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFATE ION, ...
著者Ugochukwu, E, Kavanagh, K, Ng, S, Arrowsmith, C, Edwards, A, Sundstrom, M, von Delft, F, Oppermann, U, Structural Genomics Consortium (SGC)
登録日2005-03-23
公開日2005-04-05
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structure of Human Sepiapterin Reductase
To be Published
1Z70
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1.15A resolution structure of the formylglycine generating enzyme FGE
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, C-alpha-formyglycine-generating enzyme, ...
著者Rudolph, M.G.
登録日2005-03-23
公開日2005-07-22
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献De novo calcium/sulfur SAD phasing of the human formylglycine-generating enzyme using in-house data.
Acta Crystallogr.,Sect.D, 61, 2005
1Z71
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thrombin and P2 pyridine N-oxide inhibitor complex structure
分子名称: Hirudin IIIB', L17, thrombin
著者Nantermet, P.G, Burgey, C.S, Robinson, K.A, Pellicore, J.M, Newton, C.L, Deng, J.Z, Lyle, T.A, Selnick, H.G, Lewis, S.D, Lucas, B.J, Krueger, J.A, Miller-Stein, C, White, R.B, Wong, B, McMasters, D.R, Wallace, A.A, Lynch Jr, J.J, Yan, Y, Chen, Z, Kuo, L, Gardell, S.J, Shafer, J.A, Vacca, J.P.
登録日2005-03-23
公開日2005-05-17
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献P(2) pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold
BIOORG.MED.CHEM.LETT., 15, 2005
1Z72
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Structure of a putative transcriptional regulator from Streptococcus pneumoniae
分子名称: ACETIC ACID, MAGNESIUM ION, transcriptional regulator, ...
著者Cuff, M.E, Zhou, M, Abdullah, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG)
登録日2005-03-23
公開日2005-05-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structure of a putative transcriptional regulator from Streptococcus pneumoniae
To be Published

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