PDB: 46188 件ウェブページステータス検索Chemie searchBIRD

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4UND	HUMAN ARTD1 (PARP1) - CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR TALAZOPARIB 分子名称: (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one, POLY [ADP-RIBOSE] POLYMERASE 1, SODIUM ION 著者 Karlberg, T, Thorsell, A.G, Ekblad, T, Klepsch, M, Pinto, A.F, Tresaugues, L, Moche, M, Schuler, H. 登録日 2014-05-27 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J. Med. Chem., 60, 2017
4UNR	Mtb TMK in complex with compound 23 分子名称: 4-[3-cyano-2-oxo-7-(1H-pyrazol-4-yl)-5,6-dihydro-1H-benzo[h]quinolin-4-yl]benzoic acid, MAGNESIUM ION, Thymidylate kinase 著者 Read, J.A, Hussein, S, Gingell, H, Tucker, J. 登録日 2014-05-30 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structure Guided Lead Generation for M. Tuberculosis Thymidylate Kinase (Mtb Tmk): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-One as Potent Inhibitors. J.Med.Chem., 58, 2015
8SBU	Crystal structure of MBP fusion with HPPK from Methanocaldococcus jannaschii 分子名称: Maltose/maltodextrin-binding periplasmic protein,6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Shaw, G.X, Needle, D, Stair, N.R, Cherry, S, Tropea, J.E, Waugh, D.S, Ji, X. 登録日 2023-04-04 公開日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of MBP fusion with HPPK from Methanocaldococcus jannaschii To be published
7KM6	APOBEC3B antibody 5G7 Fv-clasp 分子名称: 1,2-ETHANEDIOL, 5G7 human monoclonal FAB heavy chain, 5G7 human monoclonal FAB light chain, ... 著者 Tang, H, Shi, K, Aihara, H. 登録日 2020-11-02 公開日 2021-05-12 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Structural Characterization of a Minimal Antibody against Human APOBEC3B. Viruses, 13, 2021
4UHK	Crystal structure of the receiver domain of CpxR from E. coli (phosphorylated) 分子名称: MAGNESIUM ION, TRANSCRIPTIONAL REGULATORY PROTEIN CPXR 著者 Mechaly, A.E, Alzari, P.M.A. 登録日 2015-03-24 公開日 2016-04-13 最終更新日 2017-06-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase. Structure, 25, 2017
8RHS	Structure of the ZnF domain from human Roquin-1 分子名称: Roquin-1 著者 Schlundt, A, Tants, J.N. 登録日 2023-12-16 公開日 2024-07-03 最終更新日 2024-09-18 実験手法 SOLUTION NMR 主引用文献 Structure and RNA-binding of the helically extended Roquin CCCH-type zinc finger. Nucleic Acids Res., 52, 2024
3NOP	Light-induced intermediate structure L1 of Pseudomonas aeruginosa bacteriophytochrome 分子名称: BILIVERDINE IX ALPHA, Bacteriophytochrome 著者 Yang, X, Ren, Z, Moffat, K. 登録日 2010-06-25 公開日 2012-11-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Temperature-scan cryocrystallography reveals reaction intermediates in bacteriophytochrome. Nature, 479, 2011
4UNN	Mtb TMK in complex with compound 8 分子名称: 4-[3-cyano-6-(3-methoxyphenyl)-2-oxo-1H-pyridin-4-yl]benzoic acid, THYMIDYLATE KINASE 著者 Read, J.A, Hussein, S, Gingell, H, Tucker, J. 登録日 2014-05-29 公開日 2015-06-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure Guided Lead Generation for M. Tuberculosis Thymidylate Kinase (Mtb Tmk): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-One as Potent Inhibitors. J.Med.Chem., 58, 2015
3NOU	Light-induced intermediate structure L3 of P. aeruginosa bacteriophytochrome 分子名称: BILIVERDINE IX ALPHA, Bacteriophytochrome 著者 Yang, X, Ren, Z, Moffat, K. 登録日 2010-06-25 公開日 2012-11-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Temperature-scan cryocrystallography reveals reaction intermediates in bacteriophytochrome. Nature, 479, 2011
4M38	Crystal structure of Trypanosoma brucei protein arginine methyltransferase 7 complex with AdoHcy and histone H4 peptide 分子名称: Histone H4, Protein arginine N-methyltransferase 7, S-ADENOSYL-L-HOMOCYSTEINE 著者 Wang, C, Zhu, Y, Shi, Y. 登録日 2013-08-06 公開日 2014-04-23 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural determinants for the strict monomethylation activity by trypanosoma brucei protein arginine methyltransferase 7. Structure, 22, 2014
3ITZ	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridazine Inhibitor 分子名称: 4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-1H-pyrazolo[3,4-d]pyridazin-4-yl]amino}benzamide, Mitogen-activated protein kinase 14 著者 Mohr, C, Jordan, S. 登録日 2009-08-28 公開日 2010-03-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorg.Med.Chem.Lett., 20, 2010
3O0G	Crystal Structure of Cdk5:p25 in complex with an ATP analogue 分子名称: Cell division protein kinase 5, Cyclin-dependent kinase 5 activator 1, {4-amino-2-[(4-chlorophenyl)amino]-1,3-thiazol-5-yl}(3-nitrophenyl)methanone 著者 Mapelli, M. 登録日 2010-07-19 公開日 2011-01-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Defining Cdk5 ligand chemical space with small molecule inhibitors of Tau phosphorylation Chem.Biol., 12, 2005
4UMV	CRYSTAL STRUCTURE OF A ZINC-TRANSPORTING PIB-TYPE ATPASE IN THE E2P STATE 分子名称: BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ZINC-TRANSPORTING ATPASE 著者 Wang, K.T, Sitsel, O, Meloni, G, Autzen, H.E, Andersson, M, Klymchuk, T, Nielsen, A.M, Rees, D.C, Nissen, P, Gourdon, P. 登録日 2014-05-21 公開日 2014-08-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure and Mechanism of Zn(2+)-Transporting P-Type Atpases. Nature, 514, 2014
4UOF	Crystallographic structure of nucleoside diphosphate kinase from Litopenaeus vannamei complexed with dADP 分子名称: 2'-DEOXYADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, NUCLEOSIDE DIPHOSPHATE KINASE 著者 Lopez-Zavala, A.A, Stojanoff, V, Rudino-Pinera, E, Sotelo-Mundo, R.R. 登録日 2014-06-03 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.102 Å) 主引用文献 Structure of Nucleoside Diphosphate Kinase from the Pacific Shrimp (Litopenaeus Vannamei) in Binary Complexes with Purine and Pyrimidine Nucleoside Diphosphates Acta Crystallogr.,Sect.F, 79, 2014
8S6H	Cryo-EM Structure of the R388 plasmid conjugative pilus reveals a helical polymer characterised by an unusual pilin/phospholipid binary complex 分子名称: 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, TrwL protein 著者 Vadakkepat, A.K, Waksman, G, Redzej, A. 登録日 2024-02-27 公開日 2024-07-24 最終更新日 2024-09-18 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Cryo-EM structure of the R388 plasmid conjugative pilus reveals a helical polymer characterized by an unusual pilin/phospholipid binary complex. Structure, 32, 2024
4UOG	Crystallographic structure of nucleoside diphosphate kinase from Litopenaeus vannamei complexed with dCDP 分子名称: DEOXYCYTIDINE DIPHOSPHATE, MAGNESIUM ION, NUCLEOSIDE DIPHOSPHATE KINASE 著者 Lopez-Zavala, A.A, Stojanoff, V, Rudino-Pinera, E, Sotelo-Mundo, R.R. 登録日 2014-06-03 公開日 2014-09-10 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of Nucleoside Diphosphate Kinase from Pacific Shrimp (Litopenaeus Vannamei) in Binary Complexes with Purine and Pyrimidine Nucleoside Diphosphates Acta Crystallogr.,Sect.F, 79, 2014
3NOQ	Crystal Structure of C101S Isocyanide Hydratase from Pseudomonas fluorescens 分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ThiJ/PfpI family protein 著者 Lakshminarasimhan, M, Madzelan, P, Nan, R, Milkovic, N.M, Wilson, M.A. 登録日 2010-06-25 公開日 2010-07-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Evolution of New Enzymatic Function by Structural Modulation of Cysteine Reactivity in Pseudomonas fluorescens Isocyanide Hydratase. J.Biol.Chem., 285, 2010
8S30	Crystal structure of human PLK1 Polo-Box Domain in complex with Mis18 分子名称: Protein Mis18-alpha, Serine/threonine-protein kinase PLK1 著者 Jeyaprakash, A.A, Medina-Pritchard, B. 登録日 2024-02-19 公開日 2024-08-21 最終更新日 2024-09-18 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance. Science, 385, 2024
3NOR	Crystal Structure of T102S Isocyanide Hydratase from Pseudomonas fluorescens 分子名称: CITRIC ACID, ThiJ/PfpI family protein 著者 Lakshminarasimhan, M, Madzelan, P, Nan, R, Milkovic, N.M, Wilson, M.A. 登録日 2010-06-25 公開日 2010-07-07 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Evolution of New Enzymatic Function by Structural Modulation of Cysteine Reactivity in Pseudomonas fluorescens Isocyanide Hydratase. J.Biol.Chem., 285, 2010
3NUF	Crystal structure of a PRD-containing transcription regulator (LSEI_2718) from Lactobacillus casei ATCC 334 at 1.38 A resolution 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, PRD-containing transcription regulator, ... 著者 Joint Center for Structural Genomics (JCSG) 登録日 2010-07-06 公開日 2010-09-08 最終更新日 2019-07-17 実験手法 X-RAY DIFFRACTION (1.38 Å) 主引用文献 Crystal structure of a PRD-containing transcription regulator (LSEI_2718) from Lactobacillus casei ATCC 334 at 1.38 A resolution To be published
8S31	Crystal structure of human PLK1 Polo-Box Domain in complex with Mis18BP1 分子名称: Mis18-binding protein 1, Serine/threonine-protein kinase PLK1 著者 Jeyaprakash, A.A, Medina-Pritchard, B. 登録日 2024-02-19 公開日 2024-08-21 最終更新日 2024-09-18 実験手法 X-RAY DIFFRACTION (2.134 Å) 主引用文献 PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance. Science, 385, 2024
3IW8	Structure of Inactive Human p38 MAP Kinase in Complex with a Thiazole-Urea 分子名称: 1-{4-[(1S)-1-amino-2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-(3-chloro-4-fluorophenyl)urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Gruetter, C, Simard, J.R, Rauh, D. 登録日 2009-09-02 公開日 2009-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha J.Am.Chem.Soc., 131, 2009
3NOT	Light-induced intermediate structure L2 of P. aeruginosa bacteriophytochrome 分子名称: BILIVERDINE IX ALPHA, Bacteriophytochrome 著者 Yang, X, Ren, Z, Moffat, K. 登録日 2010-06-25 公開日 2012-11-28 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Temperature-scan cryocrystallography reveals reaction intermediates in bacteriophytochrome. Nature, 479, 2011
3FKN	P38 kinase crystal structure in complex with RO7125 分子名称: 3-[2-chloro-5-(methylsulfonyl)phenyl]-6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrimidine, Mitogen-activated protein kinase 14 著者 Kuglstatter, A, Ghate, M. 登録日 2008-12-17 公開日 2009-12-22 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity To be Published
8RR5	MenT1 toxin (rv0078a) from Mycobacterium tuberculosis H37Rv, phosphorylated at T39 分子名称: Nucleotidyl transferase AbiEii/AbiGii toxin family protein 著者 Arrowsmith, T.J, Blower, T.R. 登録日 2024-01-22 公開日 2024-09-11 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins. Nat Commun, 15, 2024

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