3IW8

Structure of Inactive Human p38 MAP Kinase in Complex with a Thiazole-Urea

Summary for 3IW8

Entry DOI	10.2210/pdb3iw8/pdb
Related	3IW5 3IW6 3IW7
Descriptor	Mitogen-activated protein kinase 14, 1-{4-[(1S)-1-amino-2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-(3-chloro-4-fluorophenyl)urea, octyl beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywords	dfg-out, type-iii, thiazole, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	41948.23
Authors	Gruetter, C.,Simard, J.R.,Rauh, D. (deposition date: 2009-09-02, release date: 2009-11-17, Last modification date: 2023-11-01)
Primary citation	Simard, J.R.,Gruetter, C.,Pawar, V.,Aust, B.,Wolf, A.,Rabiller, M.,Wulfert, S.,Robubi, A.,Kluter, S.,Ottmann, C.,Rauh, D. High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha J.Am.Chem.Soc., 131:18478-18488, 2009 Cited by PubMed: 19950957 DOI: 10.1021/ja907795q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation