PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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3GI3	Crystal structure of a N-Phenyl-N'-Naphthylurea analog in complex with p38 MAP kinase 分子名称: Mitogen-activated protein kinase 14, N-{5-tert-butyl-2-methoxy-3-[({4-[6-(morpholin-4-ylmethyl)pyridin-3-yl]naphthalen-1-yl}carbamoyl)amino]phenyl}methanesulfonamide 著者 Qian, K.C. 登録日 2009-03-05 公開日 2009-10-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery and characterization of the N-phenyl-N'-naphthylurea class of p38 kinase inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
3GC7	The structure of p38alpha in complex with a dihydroquinazolinone 分子名称: 5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-7-[1-(1-methylethyl)piperidin-4-yl]-3,4-dihydroquinazolin-2(1H)-one, Mitogen-activated protein kinase 14 著者 Scapin, G, Patel, S.B. 登録日 2009-02-21 公開日 2009-07-21 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The three-dimensional structure of MAP kinase p38beta: different features of the ATP-binding site in p38beta compared with p38alpha. Acta Crystallogr.,Sect.D, 65, 2009
4O62	CW-type zinc finger of ZCWPW2 in complex with the amino terminus of histone H3 分子名称: Histone H3.3, UNKNOWN ATOM OR ION, ZINC ION, ... 著者 Liu, Y, Tempel, W, Dong, A, Loppnau, P, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2013-12-20 公開日 2014-03-26 最終更新日 2016-06-08 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins. J.Biol.Chem., 291, 2016
6RTL	BACTERIOPHAGE SPP1 PROCAPSID-II PROTEIN 分子名称: Major capsid protein 著者 Ignatiou, A, Brasiles, S, El Sadek, M, Buerger, J, Mielke, T, Topf, M, Tavares, P. 登録日 2019-05-24 公開日 2019-10-23 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Structural transitions during the scaffolding-driven assembly of a viral capsid. Nat Commun, 10, 2019
1G2N	CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF THE ULTRASPIRACLE PROTEIN USP, THE ORTHOLOG OF RXRS IN INSECTS 分子名称: L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, ULTRASPIRACLE PROTEIN 著者 Billas, I.M.L, Moulinier, L, Rochel, N, Moras, D, Structural Proteomics in Europe (SPINE) 登録日 2000-10-20 公開日 2001-04-21 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects. J.Biol.Chem., 276, 2001
4JYH	Crystal structure of RARbeta LBD in complex with selective agonist BMS948 [4-{[(8-phenylnaphthalen-2-yl)carbonyl]amino}benzoic acid] 分子名称: 4-{[(8-phenylnaphthalen-2-yl)carbonyl]amino}benzoic acid, CITRATE ANION, Nuclear receptor coactivator 1, ... 著者 Nadendla, E.K, Teyssier, C, Germain, P, Delfosse, V, Bourguet, W. 登録日 2013-03-29 公開日 2014-03-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor beta (RAR beta , NR1B2) Selective Agonist. Plos One, 10, 2015
4UAE	Importin alpha 3 delta IBB in complex with Influenza PB2 Nuclear Localization Domain 分子名称: Importin subunit alpha-3, Polymerase basic protein 2, SULFATE ION 著者 Pumroy, R.A, Cingolani, G. 登録日 2014-08-08 公開日 2015-02-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular Determinants for Nuclear Import of Influenza A PB2 by Importin alpha Isoforms 3 and 7. Structure, 23, 2015
4JYG	Crystal structure of RARbeta LBD in complex with agonist BMS411 [4-{[(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)carbonyl]amino}benzoic acid] 分子名称: 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 4-{[(5,5-dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)carbonyl]amino}benzoic acid, CITRATE ANION, ... 著者 Nadendla, E.K, Teyssier, C, Germain, P, Delfosse, V, Bourguet, W. 登録日 2013-03-29 公開日 2014-03-19 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor beta (RAR beta , NR1B2) Selective Agonist. Plos One, 10, 2015
3IW5	Human p38 MAP Kinase in Complex with an Indole Derivative 分子名称: Mitogen-activated protein kinase 14, N-[2-(3-{[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]sulfanyl}-1H-indol-1-yl)ethyl]-3-(trifluoromethyl)benzamide, octyl beta-D-glucopyranoside 著者 Gruetter, C, Simard, J.R, Rauh, D. 登録日 2009-09-02 公開日 2009-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 High-Throughput Screening To Identify Inhibitors Which Stabilize Inactive Kinase Conformations in p38alpha J.Am.Chem.Soc., 131, 2009
5FSH	Crystal structure of Thermus thermophilus Csm6 分子名称: CSM6, NICKEL (II) ION 著者 Niewoehner, O, Jinek, M. 登録日 2016-01-06 公開日 2016-01-27 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Structural Basis for the Endoribonuclease Activity of the Type III-A Crispr-Associated Protein Csm6. RNA, 22, 2016
4UAD	Importin alpha 7 delta IBB in complex with Influenza PB2 Nuclear Localization Domain 分子名称: Importin subunit alpha-7, Polymerase basic protein 2 著者 Pumroy, R.A, Cingolani, G. 登録日 2014-08-08 公開日 2015-02-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Molecular Determinants for Nuclear Import of Influenza A PB2 by Importin alpha Isoforms 3 and 7. Structure, 23, 2015
4KZM	Crystal Structure of TR3 LBD S553A Mutant 分子名称: GLYCEROL, Nuclear receptor subfamily 4 group A member 1 著者 Li, F, Zhang, Q, Li, A, Tian, X, Cai, Q, Wang, W, Wang, Y, Chen, H, Xing, Y, Wu, Q, Lin, T. 登録日 2013-05-30 公開日 2013-12-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol., 10, 2014
3H9K	Structures of Thymidylate Synthase R163K with Substrates and Inhibitors Show Subunit Asymmetry 分子名称: 1,2-ETHANEDIOL, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, PHOSPHATE ION, ... 著者 Gibson, L.M, Lovelace, L.L, Lebioda, L. 登録日 2009-04-30 公開日 2010-05-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding. Acta Crystallogr.,Sect.D, 67, 2011
4NYN	Crystal structure of RNase H1 from halophilic archaeon Halobacterium salinarum NRC-1 分子名称: MANGANESE (II) ION, Ribonuclease HI 著者 You, D.J, Angkawidjaja, C, Koga, Y, Kanaya, S. 登録日 2013-12-11 公開日 2014-02-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Crystal structure of RNase H1 from halophilic archaeon Halobacterium salinarum NRC-1 To be Published
3HEG	P38 in complex with Sorafenib 分子名称: 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, Mitogen-activated protein kinase 14 著者 Namboodiri, H.V, Karpusas, M. 登録日 2009-05-08 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases. Biochemistry, 49, 2010
6IZ2	Crystal structure of DinB/YfiT protein DR0053 from D. radiodurans R1 分子名称: ACETATE ION, DinB/YfiT family protein, ZINC ION 著者 Kim, M.-K, Zhang, J, Zhao, L. 登録日 2018-12-18 公開日 2019-05-15 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (2.069 Å) 主引用文献 Crystal structure of the highly radiation-inducible DinB/YfiT superfamily protein DR0053 from Deinococcus radiodurans R1. Biochem.Biophys.Res.Commun., 513, 2019
8XMS	Crystal structure of Porcine Circovirus type II Rep ATPase domain 分子名称: Replication-associated protein 著者 Guan, S.Y, Song, Y.F. 登録日 2023-12-28 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the ATPase domain of porcine circovirus type 2 Rep protein. J.Gen.Virol., 105, 2024
3HGQ	Structural and functional studies of the yeast class II Hda1 HDAC complex 分子名称: HDA1 complex subunit 3 著者 Lee, J.H, Maskos, K, Huber, R. 登録日 2009-05-14 公開日 2009-08-18 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural and Functional Studies of the Yeast Class II Hda1 Histone Deacetylase Complex. J.Mol.Biol., 391, 2009
3HL7	Crystal Structure of Human p38alpha complexed with SD-0006 分子名称: 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, 2-{4-[5-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-3-yl]piperidin-1-yl}-2-oxoethanol, Mitogen-activated protein kinase 14 著者 Shieh, H.-S, Kurumbail, R.G, Stegeman, R.A, Williams, J.M. 登録日 2009-05-26 公開日 2009-07-14 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804. Biochemistry, 48, 2009
4KZJ	Crystal Structure of TR3 LBD L449W Mutant 分子名称: GLYCEROL, Nuclear receptor subfamily 4 group A member 1 著者 Li, F, Zhang, Q, Li, A, Tian, X, Cai, Q, Wang, W, Wang, Y, Chen, H, Xing, Y, Wu, Q, Lin, T. 登録日 2013-05-30 公開日 2013-12-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat.Chem.Biol., 10, 2014
3ITZ	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridazine Inhibitor 分子名称: 4-chloro-N-cyclopropyl-3-{[1-(2,6-difluorophenyl)-1H-pyrazolo[3,4-d]pyridazin-4-yl]amino}benzamide, Mitogen-activated protein kinase 14 著者 Mohr, C, Jordan, S. 登録日 2009-08-28 公開日 2010-03-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase. Bioorg.Med.Chem.Lett., 20, 2010
3QO9	Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with TSAO-T, a non-nucleoside RT inhibitor (NNRTI) 分子名称: 1-[(5R,6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4(1H,3H)-dione, Reverse transcriptase/ ribonuclease H, p51 RT 著者 Das, K, Arnold, E. 登録日 2011-02-09 公開日 2011-05-04 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure of tert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket. J.Med.Chem., 54, 2011
1IE9	Crystal Structure Of The Nuclear Receptor For Vitamin D Ligand Binding Domain Bound to MC1288 分子名称: 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, VITAMIN D3 RECEPTOR 著者 Tocchini-Valentini, G, Rochel, N, Wurtz, J.M, Mitschler, A, Moras, D. 登録日 2001-04-09 公開日 2001-05-16 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal structures of the vitamin D receptor complexed to superagonist 20-epi ligands. Proc.Natl.Acad.Sci.USA, 98, 2001
5H64	Cryo-EM structure of mTORC1 分子名称: Regulatory-associated protein of mTOR, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8 著者 Yang, H, Wang, J, Liu, M, Chen, X, Huang, M, Tan, D, Dong, M, Wong, C.C.L, Wang, J, Xu, Y, Wang, H. 登録日 2016-11-10 公開日 2017-01-25 最終更新日 2019-11-06 実験手法 ELECTRON MICROSCOPY (4.4 Å) 主引用文献 4.4 angstrom Resolution Cryo-EM structure of human mTOR Complex 1 Protein Cell, 7, 2016
5H7S	Structural basis of the flanking zinc-finger motifs crucial for the E3 ligase activity of the LNX1 RING domain 分子名称: E3 ubiquitin-protein ligase LNX, Ubiquitin-conjugating enzyme E2 N, Ubiquitin-like 1, ... 著者 Nayak, D, Sivaraman, J. 登録日 2016-11-21 公開日 2017-11-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.49 Å) 主引用文献 Structure of LNX1:Ubc13~Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1. J. Mol. Biol., 430, 2018

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