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3QO9

Crystal structure of HIV-1 Reverse Transcriptase (RT) in complex with TSAO-T, a non-nucleoside RT inhibitor (NNRTI)

Summary for 3QO9
Entry DOI10.2210/pdb3qo9/pdb
Related2ZD1 3DLK
DescriptorReverse transcriptase/ ribonuclease H, p51 RT, 1-[(5R,6R,8R,9R)-4-amino-9-{[tert-butyl(dimethyl)silyl]oxy}-6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-5-methylpyrimidine-2,4(1H,3H)-dione, ... (4 entities in total)
Functional Keywordsaids, hiv, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, nonnucleoside, nnrti, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological sourceHuman immunodeficiency virus type 1 BH10 (HIV-1)
More
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
Total number of polymer chains2
Total formula weight114674.69
Authors
Das, K.,Arnold, E. (deposition date: 2011-02-09, release date: 2011-05-04, Last modification date: 2023-09-13)
Primary citationDas, K.,Bauman, J.D.,Rim, A.S.,Dharia, C.,Clark, A.D.,Camarasa, M.J.,Balzarini, J.,Arnold, E.
Crystal Structure of tert-Butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in Complex with HIV-1 Reverse Transcriptase (RT) Redefines the Elastic Limits of the Non-nucleoside Inhibitor-Binding Pocket.
J.Med.Chem., 54:2727-2737, 2011
Cited by
PubMed: 21446702
DOI: 10.1021/jm101536x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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