7VUH
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![BU of 7vuh by Molmil](/molmil-images/mine/7vuh) | Cryo-EM structure of a class A orphan GPCR | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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2FPV
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6IEP
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![BU of 6iep by Molmil](/molmil-images/mine/6iep) | GAPDH of Streptococcus agalactiae | 分子名称: | Glyceraldehyde-3-phosphate dehydrogenase | 著者 | Ponnuraj, K, Nagarajan, R. | 登録日 | 2018-09-15 | 公開日 | 2019-01-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal structure of GAPDH of Streptococcus agalactiae and characterization of its interaction with extracellular matrix molecules Microb. Pathog., 127, 2018
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3ELN
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2RFZ
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![BU of 2rfz by Molmil](/molmil-images/mine/2rfz) | Crystal structure of cellobiohydrolase from Melanocarpus albomyces complexed with cellotriose | 分子名称: | Cellulose 1,4-beta-cellobiosidase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Parkkinen, T, Koivula, A, Vehmaanper, J, Rouvinen, J. | 登録日 | 2007-10-02 | 公開日 | 2008-09-16 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structures of Melanocarpus albomyces cellobiohydrolase Cel7B in complex with cello-oligomers show high flexibility in the substrate binding Protein Sci., 17, 2008
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4KTF
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![BU of 4ktf by Molmil](/molmil-images/mine/4ktf) | Crystal structure of Mycobacterium tuberculosis CYP121 in complex with 4,4'-(3-amino-1H-pyrazole-4,5-diyl)diphenol | 分子名称: | 4,4'-(3-amino-1H-pyrazole-4,5-diyl)diphenol, Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Hudson, S.A. | 登録日 | 2013-05-20 | 公開日 | 2013-07-03 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Overcoming the Limitations of Fragment Merging: Rescuing a Strained Merged Fragment Series Targeting Mycobacterium tuberculosis CYP121. Chemmedchem, 8, 2013
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7VUJ
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![BU of 7vuj by Molmil](/molmil-images/mine/7vuj) | Cryo-EM structure of a class A orphan GPCR | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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4OPG
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![BU of 4opg by Molmil](/molmil-images/mine/4opg) | Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase. | 分子名称: | Conserved Archaeal protein, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GERANYLGERANYL DIPHOSPHATE, ... | 著者 | McAndrew, R.P, Kung, Y, Xie, X, Liu, C, Pereira, J.H, Keasling, J.D, Adams, P.D. | 登録日 | 2014-02-05 | 公開日 | 2014-07-09 | 最終更新日 | 2014-07-23 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Constructing tailored isoprenoid products by structure-guided modification of geranylgeranyl reductase. Structure, 22, 2014
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7VUI
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![BU of 7vui by Molmil](/molmil-images/mine/7vui) | Cryo-EM structure of a class A orphan GPCR | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Chimera of Endo-1,4-beta-xylanase and Probable G-protein coupled receptor 139, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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6AD5
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5XPE
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![BU of 5xpe by Molmil](/molmil-images/mine/5xpe) | Neutron structure of the T26H mutant of T4 lysozyme | 分子名称: | CHLORIDE ION, Endolysin, SODIUM ION | 著者 | Hiromoto, T, Kuroki, R. | 登録日 | 2017-06-01 | 公開日 | 2017-10-04 | 最終更新日 | 2024-04-03 | 実験手法 | NEUTRON DIFFRACTION (1.648 Å), X-RAY DIFFRACTION | 主引用文献 | Neutron structure of the T26H mutant of T4 phage lysozyme provides insight into the catalytic activity of the mutant enzyme and how it differs from that of wild type. Protein Sci., 26, 2017
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4KET
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![BU of 4ket by Molmil](/molmil-images/mine/4ket) | Crystal structure of SsoPox W263I | 分子名称: | 1,2-ETHANEDIOL, Aryldialkylphosphatase, COBALT (II) ION, ... | 著者 | Gotthard, G, Hiblot, J, Chabriere, E, Elias, M. | 登録日 | 2013-04-26 | 公開日 | 2013-10-02 | 最終更新日 | 2013-11-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Differential Active Site Loop Conformations Mediate Promiscuous Activities in the Lactonase SsoPox. Plos One, 8, 2013
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2RCL
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![BU of 2rcl by Molmil](/molmil-images/mine/2rcl) | Crystal Structure of Arabidopsis thaliana Allene Oxide Synthase (AOS, cytochrome P450 74A, CYP74A) Complexed with 12R,13S-Vernolic Acid at 2.4 A resolution | 分子名称: | (9Z)-11-[(2R,3S)-3-pentyloxiran-2-yl]undec-9-enoic acid, Cytochrome P450 74A, GLYCEROL, ... | 著者 | Lee, D.S, Nioche, P, Raman, C.S. | 登録日 | 2007-09-20 | 公開日 | 2008-08-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes. Nature, 455, 2008
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6ADG
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![BU of 6adg by Molmil](/molmil-images/mine/6adg) | Crystal Structures of IDH1 R132H in complex with AG-881 | 分子名称: | 6-(6-chloropyridin-2-yl)-N2,N4-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine, Isocitrate dehydrogenase [NADP] cytoplasmic, MAGNESIUM ION, ... | 著者 | Ma, R, Yun, C.H. | 登録日 | 2018-08-01 | 公開日 | 2018-09-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2 Biochem. Biophys. Res. Commun., 503, 2018
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7VD9
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![BU of 7vd9 by Molmil](/molmil-images/mine/7vd9) | 2.29 A structure of the human catalase | 分子名称: | Catalase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Fan, H.C, Zhang, Y, Sun, F. | 登録日 | 2021-09-06 | 公開日 | 2021-12-29 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.29 Å) | 主引用文献 | A cryo-electron microscopy support film formed by 2D crystals of hydrophobin HFBI. Nat Commun, 12, 2021
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2FUZ
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![BU of 2fuz by Molmil](/molmil-images/mine/2fuz) | UGL hexagonal crystal structure without glycine and DTT molecules | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Unsaturated glucuronyl hydrolase | 著者 | Itoh, T, Hashimoto, W, Mikami, B, Murata, K. | 登録日 | 2006-01-28 | 公開日 | 2006-05-30 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Substrate recognition by unsaturated glucuronyl hydrolase from Bacillus sp. GL1 Biochem.Biophys.Res.Commun., 344, 2006
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6IG6
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7VUG
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![BU of 7vug by Molmil](/molmil-images/mine/7vug) | Cryo-EM structure of a class A orphan GPCR in complex with Gi | 分子名称: | 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Chimera of Endo-1,4-beta-xylanase and Probable G-protein coupled receptor 139, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J. | 登録日 | 2021-11-02 | 公開日 | 2021-12-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139. Cell Res., 32, 2022
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6E0F
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![BU of 6e0f by Molmil](/molmil-images/mine/6e0f) | Mitochondrial peroxiredoxin from Leishmania infantum in complex with unfolding client protein after heat stress | 分子名称: | mitochondrial 2-cys-peroxiredoxin | 著者 | Teixeira, F, Tse, E, Makepeace, K.A.T, Borchers, C.H, Castro, H, Tomas, A.M, Poole, L.B, Southworth, D.R, Jakob, U. | 登録日 | 2018-07-06 | 公開日 | 2019-02-20 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Chaperone activation and client binding of a 2-cysteine peroxiredoxin. Nat Commun, 10, 2019
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2RCM
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![BU of 2rcm by Molmil](/molmil-images/mine/2rcm) | Crystal Structure of Arabidopsis thaliana Allene Oxide Synthase variant (F137L) (At-AOS(F137L), cytochrome P450 74A) at 1.73 A Resolution | 分子名称: | Cytochrome P450 74A, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Lee, D.S, Nioche, P, Raman, C.S. | 登録日 | 2007-09-20 | 公開日 | 2008-08-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Structural insights into the evolutionary paths of oxylipin biosynthetic enzymes. Nature, 455, 2008
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6I4R
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![BU of 6i4r by Molmil](/molmil-images/mine/6i4r) | Crystal structure of the disease-causing R460G mutant of the human dihydrolipoamide dehydrogenase at 1.44 Angstrom resolution | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dihydrolipoyl dehydrogenase, mitochondrial, ... | 著者 | Szabo, E, Wilk, P, Bui, D, Torocsik, B, Weiss, M.S, Adam-Vizi, V, Ambrus, A. | 登録日 | 2018-11-10 | 公開日 | 2019-11-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.439 Å) | 主引用文献 | Underlying molecular alterations in human dihydrolipoamide dehydrogenase deficiency revealed by structural analyses of disease-causing enzyme variants. Hum.Mol.Genet., 28, 2019
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6AFB
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![BU of 6afb by Molmil](/molmil-images/mine/6afb) | DJ-1 C106S incubated with isatin | 分子名称: | CHLORIDE ION, DIMETHYL SULFOXIDE, ISATIN, ... | 著者 | Caaveiro, J.M.M, Tashiro, S, Tsumoto, K. | 登録日 | 2018-08-08 | 公開日 | 2018-08-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery and Optimization of Inhibitors of the Parkinson's Disease Associated Protein DJ-1. ACS Chem. Biol., 13, 2018
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4KTZ
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![BU of 4ktz by Molmil](/molmil-images/mine/4ktz) | Lactococcus phage 67 RuvC | 分子名称: | MAGNESIUM ION, RuvC endonuclease | 著者 | Rafferty, J.B, Green, V. | 登録日 | 2013-05-21 | 公開日 | 2013-08-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Mutants of phage bIL67 RuvC with enhanced Holliday junction binding selectivity and resolution symmetry. Mol.Microbiol., 89, 2013
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6IHH
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![BU of 6ihh by Molmil](/molmil-images/mine/6ihh) | Crystal structure of RasADH F12 from Ralstonia.sp in complex with NADPH and A6O | 分子名称: | (2R,3S)-2-ethyl-2-[(2E)-2-(6-methoxy-3,4-dihydro-2H-naphthalen-1-ylidene)ethyl]-3-oxidanyl-cyclopentan-1-one, Alclohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Zhang, H.L, Chen, X, Liu, W.D, Wu, Q.Q, Zhu, D.M. | 登録日 | 2018-09-30 | 公開日 | 2019-10-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Efficient reductive desymmetrization of bulky 1,3-cyclodiketones enabled by structure-guided directed evolution of a carbonyl reductase. Nat Catal, 2, 2019
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3GTF
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![BU of 3gtf by Molmil](/molmil-images/mine/3gtf) | D71G/E101G/V235L mutant in organophosphorus hydrolase from Deinococcus radiodurans | 分子名称: | COBALT (II) ION, Organophosphorus hydrolase | 著者 | Hawwa, R, Larsen, S, Ratia, K, Mesecar, A. | 登録日 | 2009-03-27 | 公開日 | 2009-06-30 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structure-based and random mutagenesis approaches increase the organophosphate-degrading activity of a phosphotriesterase homologue from Deinococcus radiodurans. J.Mol.Biol., 393, 2009
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