6ADG

Crystal Structures of IDH1 R132H in complex with AG-881

Summary for 6ADG

• Entry DOI: 10.2210/pdb6adg/pdb
• Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: idh1, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 146775.98

Authors

Ma, R.,Yun, C.H. (deposition date: 2018-08-01, release date: 2018-09-05, Last modification date: 2023-11-22)

• Primary citation: Ma, R.,Yun, C.H.; Crystal structures of pan-IDH inhibitor AG-881 in complex with mutant human IDH1 and IDH2; Biochem. Biophys. Res. Commun., 503:2912-2917, 2018; PubMed: 30131249; DOI: 10.1016/j.bbrc.2018.08.068

Experimental method

X-RAY DIFFRACTION (3 Å)