PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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3MVL	P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7K 分子名称: 4-{[5-(cyclopropylcarbamoyl)-2-methylphenyl]amino}-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide, Mitogen-activated protein kinase 14 著者 Sack, J.S. 登録日 2010-05-04 公開日 2010-10-13 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-Methylphenylamino)-5-Methyl-Npropylpyrrolo[1,2-F][1,2,4] Triazine-6-Carboxamide (Bms-582949), a Clinical P38 Map Kinase Inhibitor for the Treatment of Inflammatory Diseases J.Med.Chem., 53, 2010
3MW1	p38 kinase Crystal structure in complex with small molecule inhibitor 分子名称: 8-(2,6-dichlorophenyl)-4-(2,4-difluorophenyl)-2-piperidin-4-yl-1,7-naphthyridine 7-oxide, Mitogen-activated protein kinase 14 著者 Segarra, V, Caturla, F, Lumeras, W, Roca, R, Fisher, M, Lamers, M. 登録日 2010-05-05 公開日 2011-04-27 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 1,7-Naphthyridine 1-Oxides as Novel Potent and Selective Inhibitors of p38 Mitogen Activated Protein Kinase J.Med.Chem., 54, 2011
1KKU	Crystal structure of nuclear human nicotinamide mononucleotide adenylyltransferase 分子名称: NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE 著者 Garavaglia, S, D'Angelo, I, Emanuelli, M, Carnevali, F, Pierella, F, Magni, G, Rizzi, M. 登録日 2001-12-10 公開日 2002-06-10 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of human NMN adenylyltransferase. A key nuclear enzyme for NAD homeostasis. J.Biol.Chem., 277, 2002
2GTX	Structural Basis of Catalysis by Mononuclear Methionine Aminopeptidase 分子名称: (1-AMINO-PENTYL)-PHOSPHONIC ACID, MANGANESE (II) ION, Methionine aminopeptidase, ... 著者 Ye, Q.Z. 登録日 2006-04-28 公開日 2006-07-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis of catalysis by monometalated methionine aminopeptidase. Proc.Natl.Acad.Sci.Usa, 103, 2006
2GU4	E. coli methionine aminopeptidase in complex with NleP, 1: 0.5, di-metalated 分子名称: (1-AMINO-PENTYL)-PHOSPHONIC ACID, MANGANESE (II) ION, Methionine aminopeptidase, ... 著者 Ye, Q.Z. 登録日 2006-04-28 公開日 2006-07-04 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural basis of catalysis by monometalated methionine aminopeptidase. Proc.Natl.Acad.Sci.Usa, 103, 2006
7EOE	Crystal structure of CCDC25 homodimer 分子名称: Coiled-coil domain-containing protein 25 著者 Liu, Y.R. 登録日 2021-04-22 公開日 2022-11-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal structure of CCDC25 homodimer To Be Published
2PKH	Structural Genomics, the crystal structure of the C-terminal domain of histidine utilization repressor from Pseudomonas syringae pv. tomato str. DC3000 分子名称: 1,2-ETHANEDIOL, Histidine utilization repressor 著者 Tan, K, Zhou, M, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2007-04-17 公開日 2007-05-15 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The crystal structure of the C-terminal domain of histidine utilization repressor from Pseudomonas syringae pv. tomato str. DC3000. To be Published
2H46	Native domain-swapped dimer crystal structure of the Grb2 SH2 domain 分子名称: GLYCEROL, Growth Receptor Binding Protein 2 著者 Benfield, A.P, Martin, S.F, Whiddon, B.B. 登録日 2006-05-23 公開日 2006-06-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and energetic aspects of Grb2-SH2 domain-swapping. Arch.Biochem.Biophys., 462, 2007
2KJE	NMR structure of CBP TAZ2 and adenoviral E1A complex 分子名称: CREB-binding protein, Early E1A 32 kDa protein, ZINC ION 著者 Ferreon, J.C, Martinez-Yamout, M, Dyson, H, Wright, P.E. 登録日 2009-05-27 公開日 2009-09-15 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. Proc.Natl.Acad.Sci.USA, 106, 2009
5W4N	Crystal structure of Streptococcus dysgalactiae SHP pheromone receptor Rgg2(C45S) 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, Transcriptional regulator 著者 Neiditch, M.B, Khataokar, A.A, Capodagli, G.C. 登録日 2017-06-12 公開日 2017-10-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.198 Å) 主引用文献 Activating mutations in quorum-sensing regulator Rgg2 and its conformational flexibility in the absence of an intermolecular disulfide bond. J. Biol. Chem., 292, 2017
5W4M	Crystal structure of Streptococcus dysgalactiae SHP pheromone receptor Rgg2(C45S) 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Capodagli, G.C, Neiditch, M.B. 登録日 2017-06-12 公開日 2017-10-25 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.388 Å) 主引用文献 Activating mutations in quorum-sensing regulator Rgg2 and its conformational flexibility in the absence of an intermolecular disulfide bond. J. Biol. Chem., 292, 2017
2K8F	Structural Basis for the Regulation of p53 Function by p300 分子名称: Cellular tumor antigen p53, Histone acetyltransferase p300 著者 Bai, Y, Feng, H, Jenkins, L.M, Durell, S.R, Wiodawer, A, Appella, E. 登録日 2008-09-08 公開日 2009-03-03 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structural Basis for p300 Taz2-p53 TAD1 Binding and Modulation by Phosphorylation. Structure, 17, 2009
4N73	Crystal structure of the ligand binding domain (LBD) of REV-ERB beta bound to Cobalt Protoporphyrin IX 分子名称: Nuclear receptor subfamily 1 group D member 2, PROTOPORPHYRIN IX CONTAINING CO 著者 Matta-Camacho, E, Kojetin, D. 登録日 2013-10-14 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8662 Å) 主引用文献 Structure of REV-ERB beta Ligand-binding Domain Bound to a Porphyrin Antagonist. J.Biol.Chem., 289, 2014
3F8F	Crystal structure of multidrug binding transcriptional regulator LmrR complexed with Daunomycin 分子名称: DAUNOMYCIN, Transcriptional regulator, PadR-like family 著者 Madoori, P.K, Agustiandari, H, Driessen, A.J.M, Thunnissen, A.-M.W.H. 登録日 2008-11-12 公開日 2008-12-30 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structure of the transcriptional regulator LmrR and its mechanism of multidrug recognition. Embo J., 28, 2009
3F9X	Structural Insights into Lysine Multiple Methylation by SET Domain Methyltransferases, SET8-Y334F / H4-Lys20me2 / AdoHcy 分子名称: Histone H4, Histone-lysine N-methyltransferase SETD8, S-ADENOSYL-L-HOMOCYSTEINE 著者 Couture, J.-F, Dirk, L.M.A, Brunzelle, J.S, Houtz, R.L, Trievel, R.C. 登録日 2008-11-14 公開日 2008-11-25 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Structural origins for the product specificity of SET domain protein methyltransferases. Proc.Natl.Acad.Sci.Usa, 105, 2008
1NYX	Ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with an agonist 分子名称: (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID, peroxisome proliferator activated receptor gamma 著者 Ebdrup, S, Pettersson, I, Rasmussen, H.B, Deussen, H.-J, Frost Jensen, A, Mortensen, S.B, Fleckner, J, Pridal, L, Nygaard, L, Sauerberg, P. 登録日 2003-02-14 公開日 2003-07-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar J.MED.CHEM., 46, 2003
2K8X	GlyTM1b(1-19)zip: A Chimeric Peptide Model of the N-Terminus of a Rat Short Alpha-Tropomyosin with the N-Terminus Encoded by Exon 1b in Complex with TM9d(252-284), a Peptide Model Containing the C Terminus of Alpha-Tropomyosin Encoded by Exon 9d 分子名称: TM1b(1-19)Zip 著者 Greenfield, N.J, Kotylanskaya, L, Hitchcock-DeGregori, S.E. 登録日 2008-09-25 公開日 2009-04-28 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure of the N terminus of a nonmuscle alpha-tropomyosin in complex with the C terminus: implications for actin binding. Biochemistry, 48, 2009
1OT7	Structural Basis for 3-deoxy-CDCA Binding and Activation of FXR 分子名称: 6-ETHYL-CHENODEOXYCHOLIC ACID, Bile Acid Receptor, ISO-URSODEOXYCHOLIC ACID, ... 著者 Mi, L.Z, Devarakonda, S, Harp, J.M, Han, Q, Pellicciari, R, Willson, T.M, Khorasanizadeh, S, Rastinejad, F. 登録日 2003-03-21 公開日 2004-03-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR Mol.Cell, 11, 2003
2G1J	Crystal structure of Mycobacterium tuberculosis Shikimate Kinase at 2.0 angstrom resolution 分子名称: SULFATE ION, Shikimate kinase 著者 Gan, J, Gu, Y, Li, Y, Yan, H, Ji, X. 登録日 2006-02-14 公開日 2006-07-18 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Mycobacterium tuberculosis Shikimate Kinase in Complex with Shikimic Acid and an ATP Analogue. Biochemistry, 45, 2006
2HIZ	Crystal Structure of human beta-secretase (BACE) in the presence of an inhibitor 分子名称: BENZYL [(1S)-2-({(1S,2R)-1-BENZYL-2-HYDROXY-3-[(3-METHOXYBENZYL)AMINO]PROPYL}AMINO)-2-OXO-1-{[(1-PROPYLBUTYL)SULFONYL]METHYL}ETHYL]CARBAMATE, Beta-secretase 1, PHOSPHATE ION 著者 Benson, T.E, Prince, D.B, Tomasselli, A.G, Emmons, T.L, Paddock, D.J. 登録日 2006-06-29 公開日 2007-01-23 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Design of potent inhibitors of human beta-secretase. Part 1. Bioorg.Med.Chem.Lett., 17, 2007
2NYX	Crystal structure of RV1404 from Mycobacterium tuberculosis 分子名称: Probable transcriptional regulatory protein, Rv1404 著者 Yu, M, Bursey, E.H, Radhakannan, R, Kim, C.-Y, Kaviratne, T, Woodruff, T, Segelke, B.W, Lekin, T, Toppani, D, Terwilliger, T.C, Hung, L.-W, TB Structural Genomics Consortium (TBSGC), Integrated Center for Structure and Function Innovation (ISFI) 登録日 2006-11-21 公開日 2006-12-05 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of RV1404 from Mycobacterium tuberculosis To be Published
2HK9	Crystal structure of shikimate dehydrogenase from aquifex aeolicus in complex with shikimate and NADP+ at 2.2 angstrom resolution 分子名称: (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... 著者 Gan, J.H, Prabakaran, P, Gu, Y.J, Andrykovitch, M, Li, Y, Liu, H.H, Yan, H, Ji, X. 登録日 2006-07-03 公開日 2007-06-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and biochemical analyses of shikimate dehydrogenase AroE from Aquifex aeolicus: implications for the catalytic mechanism. Biochemistry, 46, 2007
2RG5	Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11B 分子名称: Mitogen-activated protein kinase 14, N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide 著者 Sack, J.S. 登録日 2007-10-02 公開日 2008-01-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Design, Synthesis, and Anti-inflammatory Properties of Orally Active 4-(Phenylamino)-pyrrolo[2,1-f][1,2,4]triazine p38alpha Mitogen-Activated Protein Kinase Inhibitors J.Med.Chem., 51, 2008
2O63	Crystal structure of Pim1 with Myricetin 分子名称: 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase Pim-1 著者 Holder, S, Zemskova, M, Zhang, C, Tabrizizad, M, Bremer, R, Neidigh, J.W, Lilly, M.B. 登録日 2006-12-06 公開日 2007-02-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase. Mol.Cancer Ther., 6, 2007
2HUC	Structural Studies Examining the Substrate Specificity Profiles of PC-PLCBc Protein Variants 分子名称: Phospholipase C, ZINC ION 著者 Benfield, A.P, Martin, S.F, Antikainen, N.M. 登録日 2006-07-26 公開日 2006-08-08 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural studies examining the substrate specificity profiles of PC-PLC(Bc) protein variants. Arch.Biochem.Biophys., 460, 2007

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