PDB: 5425 件ウェブページステータス検索Chemie searchBIRD

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2C6E	Aurora A kinase activated mutant (T287D) in complex with a 5- aminopyrimidinyl quinazoline inhibitor 分子名称: N-{5-[(7-{[(2S)-2-HYDROXY-3-PIPERIDIN-1-YLPROPYL]OXY}-6-METHOXYQUINAZOLIN-4-YL)AMINO]PYRIMIDIN-2-YL}BENZAMIDE, SERINE/THREONINE-PROTEIN KINASE 6 著者 Pauptit, R.A, Pannifer, A.D, Breed, J, McMiken, H.H.J, Rowsell, S, Anderson, M. 登録日 2005-11-09 公開日 2006-01-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Sar and Inhibitor Complex Structure Determination of a Novel Class of Potent and Specific Aurora Kinase Inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
2DN4	Solution Structure of RSGI RUH-060, a GTF2I domain in human cDNA 分子名称: General transcription factor II-I 著者 Doi-Katayama, Y, Hirota, H, Suetake, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-25 公開日 2006-10-25 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution Structure of RSGI RUH-060, a GTF2I domain in human cDNA To be published
2DH2	Crystal Structure of human ED-4F2hc 分子名称: 4F2 cell-surface antigen heavy chain, ACETATE ION 著者 Fort, J, Fita, I, Palacin, M. 登録日 2006-03-21 公開日 2007-03-27 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The structure of human 4F2hc ectodomain provides a model for homodimerization and electrostatic interaction with plasma membrane. J.Biol.Chem., 282, 2007
2DK2	Solution structure of RRM domain in heterogeneous nuclear ribonucleoprotein R (hnRNP R) 分子名称: Heterogeneous nuclear ribonucleoprotein R 著者 He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-06 公開日 2006-10-06 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of RRM domain in heterogeneous nuclear ribonucleoprotein R (hnRNP R) To be Published
2DL6	Solution structure of the first BRK domain from human chromodomain-helicase-DNA-binding protein 8 分子名称: Chromodomain-helicase-DNA-binding protein 8 著者 Suetake, T, Nagashima, T, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-17 公開日 2006-10-17 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the first BRK domain from human chromodomain-helicase-DNA-binding protein 8 To be Published
2DSB	Crystal structure of human ADP-ribose pyrophosphatase NUDT5 分子名称: ADP-sugar pyrophosphatase 著者 Zha, M, Zhong, C, Ding, J. 登録日 2006-06-28 公開日 2006-11-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structures of Human NUDT5 Reveal Insights into the Structural Basis of the Substrate Specificity J.Mol.Biol., 364, 2006
2DO5	Solution structure of the SAP domain of human splicing factor 3B subunit 2 分子名称: Splicing factor 3B subunit 2 著者 Suzuki, S, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-27 公開日 2007-04-17 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SAP domain of human splicing factor 3B subunit 2 To be Published
2DN5	Solution Structure of RSGI RUH-057, a GTF2I domain in human cDNA 分子名称: General transcription factor II-I repeat domain-containing protein 1 著者 Doi-Katayama, Y, Hirota, H, Hayashi, F, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-25 公開日 2006-10-25 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution Structure of RSGI RUH-057, a GTF2I domain in human cDNA To be Published
2C62	Crystal Structure of the Human Transcription Cofactor PC4 in Complex with Single-Stranded DNA 分子名称: 5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP *TP*TP*TP*TP*TP*TP*TP*TP*TP*G)-3', ACTIVATED RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR P15, SULFATE ION 著者 Werten, S, Moras, D. 登録日 2005-11-07 公開日 2006-01-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.74 Å) 主引用文献 A Global Transcription Cofactor Bound to Juxtaposed Strands of Unwound DNA Nat.Struct.Mol.Biol., 13, 2006
2C6D	Aurora A kinase activated mutant (T287D) in complex with ADPNP 分子名称: GLYCEROL, PHOSPHATE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Pauptit, R.A, Pannifer, A.D, Breed, J, McMiken, H.H.J, Rowsell, S, Anderson, M. 登録日 2005-11-09 公開日 2006-01-11 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Sar and Inhibitor Complex Structure Determination of a Novel Class of Potent and Specific Aurora Kinase Inhibitors. Bioorg.Med.Chem.Lett., 16, 2006
3VAP	Synthesis and SAR Studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off target kinase selectivity 分子名称: 3-(1-{2-[(3-fluoropyridinium-4-yl)amino]-2-oxoethyl}-1H-pyrazol-4-yl)-6-methyl-8-[(3-{[(1R,3R)-3-methylpiperidinium-1-yl]methyl}-1,2-thiazol-5-yl)amino]imidazo[1,2-a]pyrazin-1-ium, Aurora kinase A 著者 Voss, M.E, Rainka, M.P, Fleming, M, Peterson, L.H, Belanger, D.B, Siddiqui, M.A, Hruza, A, Voigt, J, Basso, A.D, Gray, K. 登録日 2011-12-29 公開日 2012-05-02 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity. Bioorg.Med.Chem.Lett., 22, 2012
3VI6	Crystal Structure of human ribosomal protein L30e 分子名称: 60S ribosomal protein L30, FORMIC ACID 著者 Kawaguchi, A, Ose, T, Yao, M, Tanaka, I. 登録日 2011-09-21 公開日 2011-12-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Crystallization and preliminary X-ray structure analysis of human ribosomal protein L30e Acta Crystallogr.,Sect.F, 67, 2011
2DHS	Solution Structure of Nucleic Acid Binding Protein CUGBP1ab and its Binding Study with DNA and RNA 分子名称: CUG triplet repeat RNA-binding protein 1 著者 Xia, Y.L, Jun, K.Y, Zhu, Q, Han, X.G, Zhang, H, Timchenko, L, Swanson, M, Gao, X.L. 登録日 2006-03-25 公開日 2007-04-24 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution Structure of Nucleic Acid Binding Protein CUGBP1ab and its Binding Study with DNA and RNA To be Published
2DW4	Crystal structure of human LSD1 at 2.3 A resolution 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1 著者 Sengoku, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-08-02 公開日 2007-09-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25A Biochem.Biophys.Res.Commun., 366, 2008
3W16	Structure of Aurora kinase A complexed to pyrazole-aminoquinoline inhibitor III 分子名称: 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1(2H)-one, Aurora kinase A 著者 Oliveira, T.M, Kairies, N.A, Engh, R.A. 登録日 2012-11-07 公開日 2014-02-05 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Flexibility and multiple conformations of the activation and glycine rich loops of Aurora A accompanying inhibitor binding To be Published
3W10	Aurora kinase A complexed to pyrazole aminoquinoline I 分子名称: 1-(3-methoxyphenyl)-N-(5-methyl-1H-pyrazol-3-yl)isoquinolin-3-amine, Aurora kinase A 著者 Oliveira, T.M, Kairies, N.A, Engh, R.A. 登録日 2012-11-06 公開日 2014-02-05 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Flexibility and multiple conformations of the activation and glycine rich loops of Aurora A accompanying inhibitor binding To be Published
2BQ0	14-3-3 Protein Beta (Human) 分子名称: 14-3-3 BETA/ALPHA 著者 Yang, X, Elkins, J.M, Fedorov, O, Longman, E.J, Sobott, L, Ball, L.J, Sundstrom, M, Arrowsmith, C, Edwards, A, Doyle, D.A. 登録日 2005-04-26 公開日 2005-05-06 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
2BR9	14-3-3 Protein Epsilon (Human) Complexed to Peptide 分子名称: 14-3-3 PROTEIN EPSILON, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS 著者 Yang, X, Elkins, J.M, Soundararajan, M, Fedorov, O, Sundstrom, M, Edwards, A, Arrowsmith, C, Doyle, D.A. 登録日 2005-05-03 公開日 2005-05-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family. Proc.Natl.Acad.Sci.USA, 103, 2006
3W18	Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XIII 分子名称: 2-{3-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide, Aurora kinase A 著者 Oliveira, T.M, Kairies, N.A, Engh, R.A. 登録日 2012-11-09 公開日 2014-02-05 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Flexibility and multiple conformations of the activation and glycine rich loops of Aurora A accompanying inhibitor binding To be Published
2BKU	Kap95p:RanGTP complex 分子名称: GTP-BINDING NUCLEAR PROTEIN RAN, GUANOSINE-5'-TRIPHOSPHATE, IMPORTIN BETA-1 SUBUNIT, ... 著者 Lee, S.J, Matsuura, Y, Liu, S.M, Stewart, M. 登録日 2005-02-21 公開日 2005-05-04 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Basis for Nuclear Import Complex Dissociation by Rangtp Nature, 435, 2005
3WPS	crystal structure of the GAP domain of MgcRacGAP(S387D) 分子名称: Rac GTPase-activating protein 1, SULFATE ION 著者 Murayama, K, Kato-murayama, M, Shirouzu, M, Kitamura, T, Yokoyama, S. 登録日 2014-01-15 公開日 2015-01-21 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 crystal structure of the GAP domain of MgcRacGAP To be Published
3WGW	Structure of PCNA bound to a small molecule inhibitor 分子名称: 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol, Proliferating cell nuclear antigen, SULFATE ION 著者 Hashimoto, H. 登録日 2013-08-12 公開日 2014-02-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin. J.Biol.Chem., 289, 2014
3W6R	Crystal structure of the GAP domain of human MgcRacGAP 分子名称: Rac GTPase-activating protein 1 著者 Matsuura, A, Lee, H.H. 登録日 2013-02-21 公開日 2014-02-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of GTPase-activating domain from human MgcRacGAP. Biochem.Biophys.Res.Commun., 435, 2013
3WPQ	crystal structure of the GAP domain of MgcRacGAP(S387A) 分子名称: Rac GTPase-activating protein 1 著者 Murayama, K, Kato-Murayama, M, Shirouzu, M, Kitamura, T, Yokoyama, S. 登録日 2014-01-15 公開日 2015-01-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 crystal structure of the GAP domain of MgcRacGAP To be Published
3W8H	Crystal structure of CCM3 in complex with the C-terminal regulatory domain of STK25 分子名称: Programmed cell death protein 10, SULFATE ION, Serine/threonine-protein kinase 25 著者 Xu, X, Wang, D.C, Ding, J. 登録日 2013-03-13 公開日 2013-07-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.426 Å) 主引用文献 Structural Basis for the Unique Heterodimeric Assembly between Cerebral Cavernous Malformation 3 and Germinal Center Kinase III. Structure, 21, 2013

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