3W16

Structure of Aurora kinase A complexed to pyrazole-aminoquinoline inhibitor III

Summary for 3W16

• Entry DOI: 10.2210/pdb3w16/pdb
• Related: 3W10 3W18
• Descriptor: Aurora kinase A, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1(2H)-one (3 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O14965
• Total number of polymer chains: 1
• Total formula weight: 32532.25

Authors

Oliveira, T.M.,Kairies, N.A.,Engh, R.A. (deposition date: 2012-11-07, release date: 2014-02-05, Last modification date: 2024-03-20)

• Primary citation: Oliveira, T.M.,Kairies, N.A.,Engh, R.A.; Flexibility and multiple conformations of the activation and glycine rich loops of Aurora A accompanying inhibitor binding; To be Published,

Experimental method

X-RAY DIFFRACTION (2.8 Å)