3W18

Structure of Aurora kinase A complexed to benzoimidazole-indazole inhibitor XIII

Summary for 3W18

• Entry DOI: 10.2210/pdb3w18/pdb
• Related: 3W10 3W16
• Descriptor: Aurora kinase A, 2-{3-[3-(1H-benzimidazol-2-yl)-1H-indazol-6-yl]-1H-pyrazol-5-yl}-N-(3-fluorophenyl)acetamide (3 entities in total)
• Functional Keywords: kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O14965
• Total number of polymer chains: 2
• Total formula weight: 65332.72

Authors

Oliveira, T.M.,Kairies, N.A.,Engh, R.A. (deposition date: 2012-11-09, release date: 2014-02-05, Last modification date: 2024-03-20)

• Primary citation: Oliveira, T.M.,Kairies, N.A.,Engh, R.A.; Flexibility and multiple conformations of the activation and glycine rich loops of Aurora A accompanying inhibitor binding; To be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)