PDB: 22592 件ウェブページステータス検索Chemie searchBIRD

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5OIT	InhA (T2A mutant) complexed with 5-((5-Amino-3-methyl-1H-pyrazol-1-yl)methyl)-N-(1-(2-chloro-6-fluorobenzyl)-1H-pyrazol-3-yl)-1,3,4-thiadiazol-2-amine 分子名称: 5-[(5-azanyl-3-methyl-pyrazol-1-yl)methyl]-~{N}-[1-[(2-chloranyl-6-fluoranyl-phenyl)methyl]pyrazol-3-yl]-1,3,4-thiadiazol-2-amine, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Convery, M.A. 登録日 2017-07-19 公開日 2018-02-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA. ChemMedChem, 13, 2018
5OIS	InhA (T2A mutant) complexed with 4-((5-Amino-3-methyl-1H-pyrazol-1-yl)methyl)-N-(2-chloro-4-fluorobenzyl)benzamide 分子名称: 4-[(5-azanyl-3-methyl-pyrazol-1-yl)methyl]-~{N}-[(2-chloranyl-4-fluoranyl-phenyl)methyl]benzamide, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Convery, M.A. 登録日 2017-07-19 公開日 2018-02-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA. ChemMedChem, 13, 2018
8EVN	Sulfatase from Mycobacterium tuberculosis (Rv3406) in complex with N-oxalylglycine (NOG) 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-ketoglutarate-dependent sulfate ester dioxygenase, N-OXALYLGLYCINE, ... 著者 Juan, T.-J, Leung, I, Squire, C.J. 登録日 2022-10-20 公開日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.644 Å) 主引用文献 Sulfatase from Mycobacterium tuberculosis (Rv3406) in complex with inhibitors NOG and FG2216 To Be Published
4U0G	Crystal Structure of M. tuberculosis ClpP1P2 bound to ADEP and agonist 分子名称: ADEP-2B5Me, ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2, ... 著者 Schmitz, K.R, Carney, D.W, Sello, J.K, Sauer, R.T. 登録日 2014-07-11 公開日 2014-10-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (3.1978 Å) 主引用文献 Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery. Proc.Natl.Acad.Sci.USA, 111, 2014
7ARU	L254N mutant of carboxypeptidase T from Thermoactinomyces vulgaris N-sulfamoyl-L-valine 分子名称: (2~{S})-3-methyl-2-(sulfamoylamino)butanoic acid, CALCIUM ION, Carboxypeptidase T, ... 著者 Timofeev, V.I, Akparov, V.K, Kuranova, I.P. 登録日 2020-10-26 公開日 2020-11-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 L254N mutant of carboxypeptidase T from Thermoactinomyces vulgaris N-sulfamoyl-L-valine To Be Published
8C9I	Cytochrome P450 CYP141A1 (Rv3121) from Mycobacterium tuberculosis 分子名称: Cytochrome P450 141, HEME B/C 著者 Selvam, I.R. 登録日 2023-01-23 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 2.05 Angstrom structure of cytochrome P450 CYP141A1 (Rv3121) from Mycobacterium tuberculosis To Be Published
4G3Q	Crystal structure of GlmU from Mycobacterium tuberculosis Snapshot 4 分子名称: Bifunctional protein GlmU, COBALT (II) ION, MAGNESIUM ION, ... 著者 Jagtap, P.A, Verma, S.K, Prakash, B. 登録日 2012-07-15 公開日 2013-08-07 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Snapshots of Glmu from Mycobacterium Tuberculosis To be Published
4V56	Crystal structure of the bacterial ribosome from Escherichia coli in complex with spectinomycin. 分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... 著者 Borovinskaya, M.A, Shoji, S, Holton, J.M, Fredrick, K, Cate, J.H.D. 登録日 2007-07-21 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.93 Å) 主引用文献 A steric block in translation caused by the antibiotic spectinomycin. Acs Chem.Biol., 2, 2007
5OIN	InhA (T2A mutant) complexed with N-(1-(pyrimidin-2-yl)piperidin-4-yl)acetamide 分子名称: Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ~{N}-(1-pyrimidin-2-ylpiperidin-4-yl)ethanamide 著者 Convery, M.A. 登録日 2017-07-19 公開日 2018-02-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA. ChemMedChem, 13, 2018
4G1X	Crystal structure of Mycobacterium tuberculosis CYP121 in complex with 4-(1H-1,2,4-triazol-1-yl)quinolin-6-amine 分子名称: 4-(1H-1,2,4-triazol-1-yl)quinolin-6-amine, Cytochrome P450 121, DIMETHYL SULFOXIDE, ... 著者 Hudson, S.A. 登録日 2012-07-11 公開日 2012-09-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Application of Fragment Screening and Merging to the Discovery of Inhibitors of the Mycobacterium tuberculosis Cytochrome P450 CYP121 Angew.Chem.Int.Ed.Engl., 51, 2012
4G3S	Crystal structure of GlmU from Mycobacterium tuberculosis in complex with uridine-diphosphate-n-acetylglucosamine and pyrophosphate Snapshot 2 分子名称: 2-acetamido-2-deoxy-1-O-phosphono-alpha-D-glucopyranose, Bifunctional protein GlmU, COBALT (II) ION, ... 著者 Jagtap, P.A, Verma, S.K, Prakash, B. 登録日 2012-07-15 公開日 2013-08-07 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Structural Snapshots of Glmu from Mycobacterium Tuberculosis To be Published
5OIM	InhA (T2A mutant) complexed with ethyl 2-methyl-4,5,6,7-tetrahydrobenzo[d]thiazole-6-carboxylate 分子名称: 2-ETHOXYETHANOL, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... 著者 Convery, M.A. 登録日 2017-07-19 公開日 2018-02-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA. ChemMedChem, 13, 2018
5OIL	InhA (T2A mutant) complexed with 1-cyclohexyl-3-(pyridin-3-ylmethyl)urea 分子名称: 1-cyclohexyl-3-(pyridin-3-ylmethyl)urea, 2-ETHOXYETHANOL, Enoyl-[acyl-carrier-protein] reductase [NADH], ... 著者 Convery, M.A. 登録日 2017-07-19 公開日 2018-02-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.76 Å) 主引用文献 Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA. ChemMedChem, 13, 2018
5OIF	InhA (T2A mutant) complexed with 1-benzyl-3-methyl-1H-pyrazol-5-amine 分子名称: 5-methyl-2-(phenylmethyl)pyrazol-3-amine, Enoyl-[acyl-carrier-protein] reductase [NADH], NICOTINAMIDE-ADENINE-DINUCLEOTIDE 著者 Convery, M.A. 登録日 2017-07-18 公開日 2018-02-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA. ChemMedChem, 13, 2018
4V9R	Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome 分子名称: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... 著者 Bulkley, D.P, Brandi, L, Polikanov, Y.S, Fabbretti, A, O'Connor, M, Gualerzi, C.O, Steitz, T.A. 登録日 2013-12-05 公開日 2014-07-09 最終更新日 2014-12-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation. Cell Rep, 6, 2014
4V64	Crystal structure of the bacterial ribosome from Escherichia coli in complex with hygromycin B. 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Borovinskaya, M.A, Shoji, S, Fredrick, K, Cate, J.H.D. 登録日 2008-06-11 公開日 2014-07-09 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structural basis for hygromycin B inhibition of protein biosynthesis Rna, 14, 2008
1A4H	STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE IN COMPLEX WITH GELDANAMYCIN 分子名称: GELDANAMYCIN, HEAT SHOCK PROTEIN 90 著者 Prodromou, C, Roe, S.M, Pearl, L.H. 登録日 1998-01-29 公開日 1998-08-05 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone Cell(Cambridge,Mass.), 90, 1997
8DWR	Crystal structure of the L333V variant of catalase-peroxidase from Mycobacterium tuberculosis 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Catalase-peroxidase, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Diaz-Vilchis, A, Uribe-Vazquez, B, Avila-Linares, A, Rudino-Pinera, E, Soberon, X. 登録日 2022-08-01 公開日 2023-08-02 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Characterization of a catalase-peroxidase variant (L333V-KatG) identified in an INH-resistant Mycobacterium tuberculosis clinical isolate. Biochem Biophys Rep, 37, 2024
8F2L	Crystal structure of Mycobacterium tuberculosis Homoserine transacetylase in complex with L-Homoserine 分子名称: Homoserine O-acetyltransferase, L-HOMOSERINE 著者 Jayasinghe, Y.P, Ronning, D.R. 登録日 2022-11-08 公開日 2023-03-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Structural and Functional Characterization of Mycobacterium tuberculosis Homoserine Transacetylase. Acs Infect Dis., 9, 2023
5KNQ	Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Guanin-9-yl)pyrrolidin-3-yl)oxymethanephosphonic acid and pyrophosphate 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, PYROPHOSPHATE 2-, ... 著者 Eng, W.S, Rejman, D, Keough, D.T, Guddat, L.W. 登録日 2016-06-28 公開日 2017-09-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.553 Å) 主引用文献 Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with pyrrolidine nucleoside phosphonate To Be Published
5KNY	Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with (3-((3R,4R)-3-(Guanin-9-yl)-4-((S)-2-hydroxy-2-phosphonoethoxy)pyrrolidin-1-yl)-3-oxopropyl)phosphonic acid 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, [3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-y l]-3-oxidanylidene-propyl]phosphonic acid 著者 Eng, W.S, Rejman, D, Keough, D.T, Guddat, L.W. 登録日 2016-06-28 公開日 2017-09-20 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.91 Å) 主引用文献 Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with pyrrolidine nucleoside phosphonate To Be Published
5KVV	Structure of Malate Dehydrogenase in complex with NADH from Mycobacterium tuberculosis 分子名称: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... 著者 Cheng, Y.S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) 登録日 2016-07-15 公開日 2016-09-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Structure of Malate Dehydrogenase in complex with NADH from Mycobacterium tuberculosis To Be Published
5JQQ	Crystal structure of glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis - apo form 分子名称: GLYCEROL, Glucosyl-3-phosphoglycerate synthase 著者 Albesa-Jove, D, Urresti, S, Gest, P.M, van der Woerd, M, Jackson, M, Guerin, M.E. 登録日 2016-05-05 公開日 2016-12-21 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis - apo form To Be Published
5KNP	Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Hypoxanthin-9-yl)pyrrolidin-3-yl)-oxymethanephosphonic acid 分子名称: Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION, PYROPHOSPHATE 2-, ... 著者 Eng, W.S, Rejman, D, Keough, D.T, Guddat, L.W. 登録日 2016-06-28 公開日 2017-09-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with pyrrolidine nucleoside phosphonate To Be Published
6VS9	Mycobacterium tuberculosis dihydrofolate reductase in complex with 3-(piperidin-1-ylmethyl)benzoic acid(fragment 11) 分子名称: 3-[(piperidin-1-yl)methyl]benzoic acid, COBALT (II) ION, Dihydrofolate reductase, ... 著者 Ribeiro, J.A, Dias, M.V.B. 登録日 2020-02-10 公開日 2020-07-15 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.842 Å) 主引用文献 Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase fromMycobacterium tuberculosis. Acs Infect Dis., 6, 2020

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