5KNQ
Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Guanin-9-yl)pyrrolidin-3-yl)oxymethanephosphonic acid and pyrophosphate
Summary for 5KNQ
Entry DOI | 10.2210/pdb5knq/pdb |
Related | 5KNP 5KNR 5KNS 5KNT 5KNU 5KNV 5KNX 5KNY |
Descriptor | Hypoxanthine-guanine phosphoribosyltransferase, [(3~{S},4~{R})-4-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)pyrrolidin-3-yl]oxymethylphosphonic acid, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphoribosyltransferase, inhibitor, complex, pyrrolidne nucleoside phosphonate, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Cellular location | Cytoplasm : P9WHQ9 |
Total number of polymer chains | 4 |
Total formula weight | 94098.43 |
Authors | Eng, W.S.,Rejman, D.,Keough, D.T.,Guddat, L.W. (deposition date: 2016-06-28, release date: 2017-09-20, Last modification date: 2023-09-27) |
Primary citation | Eng, W.S.,Rejman, D.,Keough, D.T.,Guddat, L.W. Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with pyrrolidine nucleoside phosphonate To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.553 Å) |
Structure validation
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