5KNQ

Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with [3S,4R]-(4-(Guanin-9-yl)pyrrolidin-3-yl)oxymethanephosphonic acid and pyrophosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Hypoxanthine-guanine phosphoribosyltransferase	polymer	207	22969.8	4	UniProt (P9WHQ9) Pfam (PF00156) In PDB	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	HGPRTase
2	A, B, C, D	[(3~{S},4~{R})-4-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)pyrrolidin-3-yl]oxymethylphosphonic acid	non-polymer		330.2	4	Chemie (6W8)
3	A, B, C, D	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)
4	A, B, C, D	PYROPHOSPHATE 2-	non-polymer		176.0	4	Chemie (POP)
5		water	water		18.0	140	Chemie (HOH)

Sequence modifications

A, B, C, D: 2 - 202 (UniProt: P9WHQ9)

PDB	External Database	Details
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	91879.2
Non-Polymers*	Number of molecules	16
	Total formula weight	2219.2
All*	Total formula weight	94098.4

*Water molecules are not included.