5KNY

Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with (3-((3R,4R)-3-(Guanin-9-yl)-4-((S)-2-hydroxy-2-phosphonoethoxy)pyrrolidin-1-yl)-3-oxopropyl)phosphonic acid

Summary for 5KNY

• Entry DOI: 10.2210/pdb5kny/pdb
• Related: 5KNP 5KNQ 5KNR 5KNS 5KNT 5KNU 5KNV 5KNX
• Descriptor: Hypoxanthine-guanine phosphoribosyltransferase, [3-[(3~{R},4~{R})-3-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-[(2~{S})-2-oxidanyl-2-phosphono-ethoxy]pyrrolidin-1-y l]-3-oxidanylidene-propyl]phosphonic acid, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: phosphoribosyltransferase, inhibitor, complex, pyrrolidne nucleoside phosphonate, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Cellular location: Cytoplasm : P9WHQ9
• Total number of polymer chains: 4
• Total formula weight: 93961.65

Authors

Eng, W.S.,Rejman, D.,Keough, D.T.,Guddat, L.W. (deposition date: 2016-06-28, release date: 2017-09-20, Last modification date: 2024-03-06)

• Primary citation: Eng, W.S.,Rejman, D.,Keough, D.T.,Guddat, L.W.; Crystal structure of Mycobacterium tuberculosis hypoxanthine guanine phosphoribosyltransferase in complex with pyrrolidine nucleoside phosphonate; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.91 Å)