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PDB: 12 results

6XPP
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Crystal structure of itaconate modified Mycobaterium tuberculosis isocitrate lyase
Descriptor: 2-methylidenebutanedioic acid, Isocitrate lyase, MAGNESIUM ION
Authors:Kwai, B.X.C, Bashiri, G, Leung, I.K.H.
Deposit date:2020-07-08
Release date:2020-10-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase.
Rsc Med Chem, 12, 2021
8EVN
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BU of 8evn by Molmil
Sulfatase from Mycobacterium tuberculosis (Rv3406) in complex with N-oxalylglycine (NOG)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha-ketoglutarate-dependent sulfate ester dioxygenase, N-OXALYLGLYCINE, ...
Authors:Juan, T.-J, Leung, I, Squire, C.J.
Deposit date:2022-10-20
Release date:2023-10-25
Method:X-RAY DIFFRACTION (2.644 Å)
Cite:Sulfatase from Mycobacterium tuberculosis (Rv3406) in complex with inhibitors NOG and FG2216
To Be Published
8EVO
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Sulfatase from Mycobacterium tuberculosis (Rv3406) in complex with inhibitor FG2216
Descriptor: Alpha-ketoglutarate-dependent sulfate ester dioxygenase, N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE, NICKEL (II) ION
Authors:Juan, T.-J, Leung, I, Squire, C.J.
Deposit date:2022-10-20
Release date:2023-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Sulfatase from Mycobacterium tuberculosis (Rv3406) in complex with inhibitors NOG and FG2216
To Be Published
3MS5
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Crystal Structure of Human gamma-butyrobetaine,2-oxoglutarate dioxygenase 1 (BBOX1)
Descriptor: 1,2-ETHANEDIOL, 2-(2-carboxyethyl)-1,1,1-trimethyldiazanium, Gamma-butyrobetaine dioxygenase, ...
Authors:Krojer, T, Kochan, G, McDonough, M.A, von Delft, F, Leung, I.K.H, Henry, L, Claridge, T.D.W, Pilka, E, Ugochukwu, E, Muniz, J, Filippakopoulos, P, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Kavanagh, K.L, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2010-04-29
Release date:2010-05-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structural and mechanistic studies on gamma-butyrobetaine hydroxylase.
Chem. Biol., 17, 2010
3O2G
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Crystal Structure of Human gamma-butyrobetaine,2-oxoglutarate dioxygenase 1 (BBOX1)
Descriptor: 1,2-ETHANEDIOL, 3-CARBOXY-N,N,N-TRIMETHYLPROPAN-1-AMINIUM, Gamma-butyrobetaine dioxygenase, ...
Authors:Krojer, T, Kochan, G, McDonough, M.A, von Delft, F, Leung, I.K.H, Henry, L, Claridge, T.D.W, Pilka, E, Ugochukwu, E, Muniz, J, Filippakopoulos, P, Bountra, C, Arrowsmith, C.H, Weigelt, J, Edwards, A, Kavanagh, K.L, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC)
Deposit date:2010-07-22
Release date:2010-09-15
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural and mechanistic studies on gamma-butyrobetaine hydroxylase.
Chem. Biol., 17, 2010
6EDZ
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BU of 6edz by Molmil
Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA, form I
Descriptor: ACETYL COENZYME *A, Isocitrate lyase 2
Authors:Bashiri, G, Bhusal, R, Leung, I.
Deposit date:2018-08-12
Release date:2019-08-14
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2.
Nat Commun, 10, 2019
6EE1
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BU of 6ee1 by Molmil
Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA
Descriptor: ACETYL COENZYME *A, Isocitrate lyase 2, MAGNESIUM ION
Authors:Bashiri, G, Bhusal, R, Leung, I.
Deposit date:2018-08-12
Release date:2019-08-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2.
Nat Commun, 10, 2019
6EDW
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Crystal structure of Mycobacterium tuberculosis ICL2 in the apo form
Descriptor: GLYCEROL, Isocitrate lyase 2, MAGNESIUM ION
Authors:Bashiri, G, Bhusal, R, Leung, I.
Deposit date:2018-08-12
Release date:2019-08-14
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2.
Nat Commun, 10, 2019
3LXK
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Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6
Descriptor: 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile, Tyrosine-protein kinase JAK3
Authors:Chrencik, J.E, Patny, A, Leung, I.K, Korniski, B, Emmons, T.L, Benson, T.E.
Deposit date:2010-02-25
Release date:2010-06-02
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
J.Mol.Biol., 400, 2010
8G8K
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Crystal structure of Rv1916 (residues 233-398)
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Putative isocitrate lyase subunit B
Authors:Kwai, B.X.C, Bashiri, G, Leung, I.K.H.
Deposit date:2023-02-18
Release date:2023-06-07
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Mycobacterium tuberculosis Rv1916 is an Acetyl-CoA-Binding Protein.
Chembiochem, 24, 2023
5TCV
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BU of 5tcv by Molmil
ACC oxidase complex with substrate 1-aminocyclopropane-1-carboxylic acid
Descriptor: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 1-aminocyclopropane-1-carboxylate oxidase 1, NICKEL (II) ION
Authors:Gunawardana, D.M, Yosaatmadja, Y, Leung, I.K, Squire, C.J.
Deposit date:2016-09-15
Release date:2017-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:ACC oxidase complex with substrate 1-aminocyclopropane-1-carboxylic acid
To Be Published
5TCW
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ACC oxidase complex with nickel and acetate
Descriptor: 1-aminocyclopropane-1-carboxylate oxidase 1, ACETATE ION, NICKEL (II) ION
Authors:Gunawardana, D.M, Yosaatmadja, Y, Leung, I.K, Squire, C.J.
Deposit date:2016-09-15
Release date:2017-09-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:ACC oxidase complex with substrate 1-aminocyclopropane-1-carboxylic acid
To Be Published

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