PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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2IA0	Transcriptional Regulatory Protein PF0864 From Pyrococcus Furiosus a Member of the ASNC Family (PF0864) 分子名称: GOLD ION, Putative HTH-type transcriptional regulator PF0864 著者 Yang, H, Chang, J, Liu, Z.J, Rose, J.P, Wang, B.C, Southeast Collaboratory for Structural Genomics, Southeast Collaboratory for Structural Genomics (SECSG) 登録日 2006-09-06 公開日 2006-10-31 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 Crystal Structure of the Transcriptional Regulatory Protein PF0864: an Asnc Family member from Pyrococcus Furiosus To be Published
2I5S	Crystal structure of onconase with bound nucleic acid 分子名称: 5'-D(*A*(DU)P*GP*A)-3', P-30 protein 著者 Bae, E, Lee, J.E, Raines, R.T, Wesenberg, G.E, Phillips Jr, G.N, Bitto, E, Bingman, C.A, Center for Eukaryotic Structural Genomics (CESG) 登録日 2006-08-25 公開日 2006-09-05 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural basis for catalysis by onconase. J.Mol.Biol., 375, 2008
1Q89	Crystal structure of the C-domain of the T.vaginalis Inr binding protein, IBP39 (cubic crystal form) 分子名称: 39 kDa initiator binding protein 著者 Schumacher, M.A, Johnson, P.J. 登録日 2003-08-20 公開日 2003-11-18 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural Basis of Core Promoter Recognition in a Primitive Eukaryote Cell(Cambridge,Mass.), 115, 2003
3EZG	Crystal structure of E18Q DJ-1 with oxidized C106 分子名称: Protein DJ-1 著者 Lakshminarasimhan, M, Wilson, M.A. 登録日 2008-10-22 公開日 2008-12-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Formation of a stabilized cysteine sulfinic acid is critical for the mitochondrial function of the parkinsonism protein DJ-1. J.Biol.Chem., 284, 2009
3F2A	Crystal structure of human Pim-1 in complex with DAPPA 分子名称: (2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid, MAGNESIUM ION, Proto-oncogene serine/threonine-protein kinase Pim-1 著者 Qian, K. 登録日 2008-10-29 公開日 2009-03-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode. J.Med.Chem., 52, 2009
7LFH	Cryo-EM structure of NLRP3 double-ring cage, 6-fold (12-mer) 分子名称: NACHT, LRR and PYD domains-containing protein 3 著者 Andreeva, L, Rawson, S, Wu, H. 登録日 2021-01-17 公開日 2021-12-15 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation. Cell, 184, 2021
1LUJ	Crystal Structure of the Beta-catenin/ICAT Complex 分子名称: Beta-catenin-interacting protein 1, Catenin beta-1 著者 Graham, T.A, Clements, W.K, Kimelman, D, Xu, W. 登録日 2002-05-22 公開日 2002-10-16 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. Mol.Cell, 10, 2002
8SVP	Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-278 分子名称: (1P)-N-(5-tert-butyl-2-{[(3R)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide 著者 Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. 登録日 2023-05-17 公開日 2024-05-15 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3.32 Å) 主引用文献 Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
8SVU	Crystal structure of the L428V mutant of pregnane X receptor ligand binding domain in apo form 分子名称: GLYCEROL, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1 fusion protein,Nuclear receptor coactivator 1 著者 Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. 登録日 2023-05-17 公開日 2024-05-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.89 Å) 主引用文献 Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
1MP1	Solution structure of the PWI motif from SRm160 分子名称: Ser/Arg-related nuclear matrix protein 著者 Szymczyna, B.R, Bowman, J, McCracken, S, Pineda-Lucena, A, Lu, Y, Cox, B, Lambermon, M, Graveley, B.R, Arrowsmith, C.H, Blencowe, B.J. 登録日 2002-09-11 公開日 2003-09-16 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing. Genes Dev., 17, 2003
8SVR	Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-326 分子名称: (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-5-methyl-1-(2,4,5-trimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide, DIMETHYL SULFOXIDE, Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide 著者 Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. 登録日 2023-05-17 公開日 2024-05-15 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
8SVS	Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-328 分子名称: (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-1-(2,4-dimethoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1 fusion protein,Nuclear receptor coactivator 1 著者 Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. 登録日 2023-05-17 公開日 2024-05-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
8SVT	Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-331 分子名称: DIMETHYL SULFOXIDE, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1 fusion protein,Nuclear receptor coactivator 1, ... 著者 Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. 登録日 2023-05-17 公開日 2024-05-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.39 Å) 主引用文献 Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
8SVQ	Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-312 分子名称: (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, DIMETHYL SULFOXIDE, Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide 著者 Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. 登録日 2023-05-17 公開日 2024-05-15 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
8SVX	Crystal structure of the L428V mutant of pregnane X receptor ligand binding domain in complex with SJPYT-331 分子名称: DIMETHYL SULFOXIDE, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1 fusion protein,Nuclear receptor coactivator 1, ... 著者 Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. 登録日 2023-05-17 公開日 2024-05-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
8SVO	Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-310 分子名称: (1P)-N-(5-tert-butyl-2-{[(2S)-pentan-2-yl]oxy}phenyl)-1-(2-methoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide, DIMETHYL SULFOXIDE, Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide 著者 Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. 登録日 2023-05-17 公開日 2024-05-15 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
8SVN	Crystal structure of the apo form of pregnane X receptor ligand binding domain 分子名称: Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide 著者 Garcia-Maldonado, E, Huber, A.D, Nithianantham, S, Miller, D.J, Chen, T. 登録日 2023-05-17 公開日 2024-05-15 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15, 2024
6HY0	Atomic models of P1, P4 C-terminal fragment and P8 fitted in the bacteriophage phi6 nucleocapsid reconstructed with icosahedral symmetry 分子名称: Major Outer Capsid Protein P8, Major inner protein P1, Packaging Enzyme P4 著者 El Omari, K, Ilca, S.L, Stuart, D.I, Huiskonen, J.T. 登録日 2018-10-18 公開日 2019-06-12 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Multiple liquid crystalline geometries of highly compacted nucleic acid in a dsRNA virus. Nature, 570, 2019
3HFU	Crystal structure of the ligand binding domain of E. coli CynR with its specific effector azide 分子名称: 1,2-ETHANEDIOL, AZIDE ION, HTH-type transcriptional regulator cynR 著者 Singer, A.U, Evdokimova, E, Kagan, O, Dong, A, Edwards, A.M, Savchenko, A. 登録日 2009-05-12 公開日 2009-06-09 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of the ligand binding domain of E. coli CynR with its specific effector azide TO BE PUBLISHED
8UJW	Crystal structure of the KETc7 antigen from Taenia solium 分子名称: GRAM domain-containing protein 著者 Sotelo-Mundo, R.R, Gomez-Yanes, A.C, Lopez-Zavala, A.A, Ochoa-Leyva, A. 登録日 2023-10-11 公開日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Crystal structure of the KETc7 antigen from Taenia solium To Be Published
3GIB	Crystal Structure of the Complex of the E. coli Hfq with Poly(A) 分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*A)-3', Protein hfq 著者 Link, T.M, Valentin-Hansen, P, Brennan, R.G. 登録日 2009-03-05 公開日 2009-11-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure of Escherichia coli Hfq bound to polyriboadenylate RNA Proc.Natl.Acad.Sci.USA, 106, 2009
7PW8	Human SMG1-8-9 kinase complex bound to AMPPNP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... 著者 Langer, L.M, Conti, E. 登録日 2021-10-06 公開日 2021-12-01 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.82 Å) 主引用文献 Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. Elife, 10, 2021
7PW4	Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor 分子名称: 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Langer, L.M, Conti, E. 登録日 2021-10-06 公開日 2021-12-01 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. Elife, 10, 2021
7PW9	Human SMG1-9 kinase complex bound to AMPPNP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... 著者 Langer, L.M, Conti, E. 登録日 2021-10-06 公開日 2021-12-01 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. Elife, 10, 2021
7PW5	Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C-terminus, bound to a SMG1 inhibitor 分子名称: 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Langer, L.M, Conti, E. 登録日 2021-10-06 公開日 2021-12-01 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8. Elife, 10, 2021

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