8SVR

Crystal structure of pregnane X receptor ligand binding domain in complex with SJPYT-326

Summary for 8SVR

Entry DOI	10.2210/pdb8svr/pdb
Descriptor	Pregnane X receptor ligand binding domain fused to SRC-1 coactivator peptide, DIMETHYL SULFOXIDE, (1P)-N-(5-tert-butyl-2-{[(3S)-hexan-3-yl]oxy}phenyl)-5-methyl-1-(2,4,5-trimethoxyphenyl)-1H-1,2,3-triazole-4-carboxamide, ... (4 entities in total)
Functional Keywords	pregnane x receptor (pxr), promiscuous ligand-activated protein, nuclear receptor subfamily 1, transcriptional regulator, and drug metabolism., transcription
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	80918.70
Authors	Garcia-Maldonado, E.,Huber, A.D.,Nithianantham, S.,Miller, D.J.,Chen, T. (deposition date: 2023-05-17, release date: 2024-05-15, Last modification date: 2024-05-29)
Primary citation	Garcia-Maldonado, E.,Huber, A.D.,Chai, S.C.,Nithianantham, S.,Li, Y.,Wu, J.,Poudel, S.,Miller, D.J.,Seetharaman, J.,Chen, T. Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nat Commun, 15:4054-4054, 2024 Cited by PubMed: 38744881 DOI: 10.1038/s41467-024-48472-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.92 Å)

Structure validation