8SVX
Crystal structure of the L428V mutant of pregnane X receptor ligand binding domain in complex with SJPYT-331
Summary for 8SVX
Entry DOI | 10.2210/pdb8svx/pdb |
Descriptor | Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1 fusion protein,Nuclear receptor coactivator 1, methyl 3-{[(1P)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carbonyl]amino}-4-{[(3S)-hexan-3-yl]oxy}benzoate, DIMETHYL SULFOXIDE, ... (4 entities in total) |
Functional Keywords | pregnane x receptor (pxr), promiscuous ligand-activated protein, nuclear receptor subfamily 1, transcriptional regulator, drug metabolism, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 80834.45 |
Authors | Garcia-Maldonado, E.,Huber, A.D.,Nithianantham, S.,Miller, D.J.,Chen, T. (deposition date: 2023-05-17, release date: 2024-05-15) |
Primary citation | Garcia-Maldonado, E.,Huber, A.D.,Chai, S.C.,Nithianantham, S.,Li, Y.,Wu, J.,Poudel, S.,Miller, D.J.,Seetharaman, J.,Chen, T. Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR Nat Commun, 2024 |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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