PDB: 47065 件ウェブページステータス検索Chemie searchBIRD

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8VLS	Structure of VCP in complex with an ATPase activator (D2 domains only, dodecameric form) 分子名称: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase 著者 Jones, N.H, Urnivicius, L, Kapoor, T.M. 登録日 2024-01-12 公開日 2024-06-19 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
7QZU	Structure of liver pyruvate kinase in complex with anthraquinone derivative 47 分子名称: (2~{S})-2-[2-[4-[3,4-bis(oxidanyl)-9,10-bis(oxidanylidene)anthracen-2-yl]sulfonylpiperazin-1-yl]-2-oxidanylidene-ethyl]-2-oxidanyl-butanedioic acid, 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, ... 著者 Lulla, A, Foller, A, Nain-Perez, A, Grotli, M, Brear, P, Hyvonen, M. 登録日 2022-01-31 公開日 2022-04-06 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.964 Å) 主引用文献 Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase. Eur.J.Med.Chem., 234, 2022
5DB8	Structure of human DNA polymerase beta Host-Guest complex with the N7MG base paired with a dA 分子名称: DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*AP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*(FMG)P*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... 著者 Koag, M.C, Lee, S. 登録日 2015-08-21 公開日 2015-11-11 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.547 Å) 主引用文献 N7 Methylation Alters Hydrogen-Bonding Patterns of Guanine in Duplex DNA. J.Am.Chem.Soc., 137, 2015
2VLQ	F86A mutant of E9 DNase domain in complex with Im9 分子名称: COLICIN E9, COLICIN-E9 IMMUNITY PROTEIN, MALONIC ACID 著者 Keeble, A.H, Joachimiak, L.A, Mate, M.J, Meenan, N, Kirkpatrick, N, Baker, D, Kleanthous, C. 登録日 2008-01-15 公開日 2008-05-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Experimental and Computational Analyses of the Energetic Basis for Dual Recognition of Immunity Proteins by Colicin Endonucleases. J.Mol.Biol., 379, 2008
3AY5	Crystal structure of HHM (human homologue of murine maternal Id-like molecule) 分子名称: Cyclin-D1-binding protein 1 著者 Seto, A, Ishitani, R, Nureki, O. 登録日 2011-04-28 公開日 2012-03-14 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition. Embo J., 31, 2012
3DSR	ADP in transition binding site in the subunit B of the energy converter A1Ao ATP synthase 分子名称: ADENOSINE-5'-DIPHOSPHATE, V-type ATP synthase beta chain 著者 Kumar, A, Manimekalai, S.M.S, Balakrishna, A.M, Gruber, G. 登録日 2008-07-14 公開日 2009-06-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure of the nucleotide-binding subunit B of the energy producer A1A0 ATP synthase in complex with adenosine diphosphate Acta Crystallogr.,Sect.D, 64, 2008
5EK8	Crystal structure of a 9R-lipoxygenase from Cyanothece PCC8801 at 2.7 Angstroms 分子名称: FE (II) ION, Lipoxygenase, SODIUM ION 著者 Feussner, I, Ficner, R, Neumann, P, Newie, J, Andreou, A, Einsle, O. 登録日 2015-11-03 公開日 2015-12-23 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of a lipoxygenase from Cyanothece sp. may reveal novel features for substrate acquisition. J.Lipid Res., 57, 2016
4L7T	B. fragilis NanU 分子名称: 1,2-ETHANEDIOL, ACETATE ION, NanU sialic acid binding protein, ... 著者 Rafferty, J.B, Phansopa, C, Stafford, G.P. 登録日 2013-06-14 公開日 2014-01-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 Structural and functional characterization of NanU, a novel high-affinity sialic acid-inducible binding protein of oral and gut-dwelling Bacteroidetes species. Biochem.J., 458, 2014
5EKJ	Human Carbonic Anhydrase II complexed with a two-faced guest 分子名称: 2-(butylamino)-~{N}-[2-(4-sulfamoylphenyl)ethyl]ethanamide, Carbonic anhydrase 2, GLYCEROL, ... 著者 Roose, B.W, Dmochowski, I.J. 登録日 2015-11-03 公開日 2016-01-06 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.129 Å) 主引用文献 Programming A Molecular Relay for Ultrasensitive Biodetection through (129) Xe NMR. Angew.Chem.Int.Ed.Engl., 55, 2016
5EKV	Co-crystal structure of eIF4E with nucleotide mimetic inhibitor. 分子名称: 3-[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]-4-oxidanyl-cyclobut-3-ene-1,2-dione, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1 著者 Nowicki, M.W, Walkinshaw, M.D, Fischer, P.M. 登録日 2015-11-04 公開日 2016-09-07 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.61 Å) 主引用文献 Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation. Eur.J.Med.Chem., 124, 2016
3DQJ	Structure of the Yellow Fluorescent Protein Citrine Frozen at 1000 Atmospheres Number 3: Structure 7 in a Series of 26 High Pressure Structures 分子名称: Green fluorescent protein 著者 Barstow, B, Kim, C.U. 登録日 2008-07-09 公開日 2008-09-23 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.51 Å) 主引用文献 Alteration of citrine structure by hydrostatic pressure explains the accompanying spectral shift. Proc.Natl.Acad.Sci.Usa, 105, 2008
4GS4	Structure of the alpha-tubulin acetyltransferase, alpha-TAT1 分子名称: ACETYL COENZYME *A, Alpha-tubulin N-acetyltransferase 著者 Friedmann, D.R, Fan, J, Marmorstein, R. 登録日 2012-08-27 公開日 2012-10-17 最終更新日 2013-08-28 実験手法 X-RAY DIFFRACTION (2.112 Å) 主引用文献 Structure of the alpha-tubulin acetyltransferase, alpha TAT1, and implications for tubulin-specific acetylation. Proc.Natl.Acad.Sci.USA, 109, 2012
7KHT	The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor Steroidogenic Factor-1 (SF-1) 分子名称: (2S)-3-{[(S)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane-1,2-diyl (9E,9'E)di-octadec-9-enoate, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha peptide, Steroidogenic factor 1 著者 Blind, R.D. 登録日 2020-10-22 公開日 2021-05-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.504 Å) 主引用文献 The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor steroidogenic factor-1. J.Lipid Res., 62, 2021
8VOV	Structure of VCP in complex with an ATPase activator and ADP (D2 domains only, hexameric form) 分子名称: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase 著者 Jones, N.H, Urnivicius, L, Kapoor, T.M. 登録日 2024-01-16 公開日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
3DV8	Crystal structure of a putative transcriptional regulator of the crp/fnr family (eubrec_1222) from eubacterium rectale atcc 33656 at 2.55 A resolution 分子名称: transcriptional regulator, Crp/Fnr family 著者 Joint Center for Structural Genomics (JCSG) 登録日 2008-07-18 公開日 2008-08-05 最終更新日 2019-07-24 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Crystal structure of transcriptional regulator, Crp/Fnr family (RER070207001219) from Eubacterium rectale at 2.55 A resolution To be published
4GSF	The structure analysis of cysteine free insulin degrading enzyme (ide) with (s)-2-{2-[carboxymethyl-(3-phenyl-propionyl)-amino]-acetylamino}-3-(3h-imidazol-4-yl)-propionic acid methyl ester 分子名称: Insulin-degrading enzyme, ZINC ION, methyl N-(carboxymethyl)-N-(3-phenylpropanoyl)glycyl-D-histidinate 著者 Guo, Q, Deprez-Poulain, R, Deprez, B, Tang, W.J. 登録日 2012-08-27 公開日 2013-08-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. Eur.J.Med.Chem., 90, 2015
4KWD	Crystal structure of Aspergillus terreus aristolochene synthase complexed with (1R,8R,9aS)-1,9a-dimethyl-8-(prop-1-en-2-yl)decahydroquinolizin-5-ium 分子名称: (1R,5R,8R,9aS)-1,9a-dimethyl-8-(prop-1-en-2-yl)octahydro-2H-quinolizinium, Aristolochene synthase, GLYCEROL, ... 著者 Chen, M, Al-lami, N, Janvier, M, D'Antonio, E.L, Faraldos, J.A, Cane, D.E, Allemann, R.K, Christianson, D.W. 登録日 2013-05-23 公開日 2013-08-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.857 Å) 主引用文献 Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. Biochemistry, 52, 2013
2C14	5-(4-Carboxy-2-oxo-butylamino)-4-oxo-pentanoic acid acid bound to Porphobilinogen synthase from Pseudomonas aeruginosa 分子名称: DELTA-AMINOLEVULINIC ACID DEHYDRATASE, MAGNESIUM ION 著者 Frere, F, Nentwich, M, Gacond, S, Heinz, D.W, Neier, R, Frankenberg-Dinkel, N. 登録日 2005-09-11 公開日 2006-06-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Probing the Active Site of Pseudomonas Aeruginosa Porphobilinogen Synthase Using Newly Developed Inhibitors. Biochemistry, 45, 2006
5EJD	The crystal structure of holo T3CT 分子名称: 4'-PHOSPHOPANTETHEINE, GLYCEROL, TqaA 著者 Zhang, J.R, Tang, Y, Zhou, J.H. 登録日 2015-11-01 公開日 2016-10-19 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 Structural basis of nonribosomal peptide macrocyclization in fungi Nat.Chem.Biol., 12, 2016
5CX9	Crystal structure of CK2alpha with (methyl 4-((3-(3-chloro-4-(phenyl)benzylamino)propyl)amino)-4-oxobutanoate bound 分子名称: ACETATE ION, Casein kinase II subunit alpha, PHOSPHATE ION, ... 著者 Brear, P, De Fusco, C, Georgiou, K.H, Spring, D, Hyvonen, M. 登録日 2015-07-28 公開日 2016-11-30 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.732 Å) 主引用文献 A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066. Bioorg. Med. Chem., 25, 2017
8VKU	Structure of VCP in complex with an ATPase activator (D2 domains only, hexameric form) 分子名称: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase 著者 Jones, N.H, Urnivicius, L, Kapoor, T.M. 登録日 2024-01-09 公開日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
5CZ2	Crystal structure of a two-domain fragment of MMTV integrase 分子名称: MAGNESIUM ION, Pol polyprotein, ZINC ION 著者 Cook, N, Ballandras-Colas, A, Engelman, A, Cherepanov, P. 登録日 2015-07-31 公開日 2016-02-17 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature, 530, 2016
2BKC	The X-ray structure of the H43G Listeria innocua Dps mutant 分子名称: NON-HEME IRON-CONTAINING FERRITIN 著者 Ilari, A, Stefanini, S, Chiancone, E. 登録日 2005-02-15 公開日 2005-02-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The unusual intersubunit ferroxidase center of Listeria innocua Dps is required for hydrogen peroxide detoxification but not for iron uptake. A study with site-specific mutants. Biochemistry, 44, 2005
7KJJ	Reconstructed ancestor of HIUases and Transthyretins 分子名称: 1,2-ETHANEDIOL, 3,5,3',5'-TETRAIODO-L-THYRONINE, TTR ancestor 著者 Nagem, R.A.P, Bleicher, L, Costa, M.A.F. 登録日 2020-10-26 公開日 2021-05-19 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Reenacting the Birth of a Function: Functional Divergence of HIUases and Transthyretins as Inferred by Evolutionary and Biophysical Studies. J.Mol.Evol., 89, 2021
3B8R	Crystal structure of the VEGFR2 kinase domain in complex with a naphthamide inhibitor 分子名称: 1,2-ETHANEDIOL, N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide, Vascular endothelial growth factor receptor 2 著者 Whittington, D.A, Long, A.M, Gu, Y, Zhao, H. 登録日 2007-11-01 公開日 2008-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Evaluation of a Series of Naphthamides as Potent, Orally Active Vascular Endothelial Growth Factor Receptor-2 Tyrosine Kinase Inhibitors J.Med.Chem., 51, 2008

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