7KHT

The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor Steroidogenic Factor-1 (SF-1)

Summary for 7KHT

• Entry DOI: 10.2210/pdb7kht/pdb
• Descriptor: Steroidogenic factor 1, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha peptide, (2S)-3-{[(S)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane-1,2-diyl (9E,9'E)di-octadec-9-enoate, ... (4 entities in total)
• Functional Keywords: pi(3, 4, 5)p3 acyl chains, acyl chain length, acyl chain induced conformational change, nuclear pip2, nuclear pip3, nuclear receptor, lipid binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 30530.31

Authors

Blind, R.D. (deposition date: 2020-10-22, release date: 2021-05-19, Last modification date: 2023-10-18)

• Primary citation: Bryant, J.M.,Malabanan, M.M.,Vanderloop, B.H.,Nichols, C.M.,Haratipour, Z.,Poon, K.T.,Sherrod, S.D.,McLean, J.A.,Blind, R.D.; The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor steroidogenic factor-1.; J.Lipid Res., 62:100081-100081, 2021; PubMed: 33933440; DOI: 10.1016/j.jlr.2021.100081

Experimental method

X-RAY DIFFRACTION (2.504 Å)