7QZU

Structure of liver pyruvate kinase in complex with anthraquinone derivative 47

Summary for 7QZU

Entry DOI	10.2210/pdb7qzu/pdb
Related	5SC8 5SC9 5SCA 5SCB 5SCC 5SCD 5SCE 5SCF 5SCH 5SCI 5SCJ 5SCK 5SCL 5SDT 7QDN
Descriptor	PKL, 1,6-di-O-phosphono-beta-D-fructofuranose, OXALATE ION, ... (7 entities in total)
Functional Keywords	pyruvate kinase, active site, inhibition, transferase
Biological source	Homo sapiens
Total number of polymer chains	8
Total formula weight	393590.35
Authors	Lulla, A.,Foller, A.,Nain-Perez, A.,Grotli, M.,Brear, P.,Hyvonen, M. (deposition date: 2022-01-31, release date: 2022-04-06, Last modification date: 2024-01-31)
Primary citation	Nain-Perez, A.,Foller Fuchtbauer, A.,Haversen, L.,Lulla, A.,Gao, C.,Matic, J.,Monjas, L.,Rodriguez, A.,Brear, P.,Kim, W.,Hyvonen, M.,Boren, J.,Mardinoglu, A.,Uhlen, M.,Grotli, M. Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase. Eur.J.Med.Chem., 234:114270-114270, 2022 Cited by PubMed: 35290845 DOI: 10.1016/j.ejmech.2022.114270 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.964 Å)

Structure validation