PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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4I1Z	Crystal structure of the monomeric (V948R) form of the gefitinib/erlotinib resistant EGFR kinase domain L858R+T790M 分子名称: Epidermal growth factor receptor 著者 Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. 登録日 2012-11-21 公開日 2013-01-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21, 2013
2H14	Crystal of WDR5 (apo-form) 分子名称: WD-repeat protein 5 著者 Couture, J.F, Collazo, E, Trievel, R.C. 登録日 2006-05-15 公開日 2006-07-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Molecular recognition of histone H3 by the WD40 protein WDR5. Nat.Struct.Mol.Biol., 13, 2006
3VBQ	Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design 分子名称: (5~{Z})-5-[[3-[6-[(4-azanylcyclohexyl)amino]pyrazin-2-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione, Serine/threonine-protein kinase pim-1 著者 Liu, J. 登録日 2012-01-02 公開日 2012-03-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design. J.Med.Chem., 55, 2012
6GC7	50S ribosomal subunit assembly intermediate state 1 分子名称: 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... 著者 Nikolay, R, Hilal, T, Qin, B, Loerke, J, Buerger, J, Mielke, T, Spahn, C.M.T. 登録日 2018-04-17 公開日 2018-06-20 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structural Visualization of the Formation and Activation of the 50S Ribosomal Subunit during In Vitro Reconstitution. Mol. Cell, 70, 2018
7W1R	Crystal structure of human Suv3 monomer 分子名称: ATP-dependent RNA helicase SUPV3L1, mitochondrial 著者 Jain, M, Yuan, H.S. 登録日 2021-11-20 公開日 2022-05-11 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Dimeric assembly of human Suv3 helicase promotes its RNA unwinding function in mitochondrial RNA degradosome for RNA decay. Protein Sci., 31, 2022
8D8I	Crystal structure of Reverb alpha in complex with synthetic agonist 分子名称: (4S)-6-[([1,1'-biphenyl]-2-yl)oxy]-3-chloro[1,2,4]triazolo[4,3-b]pyridazine, Nuclear receptor corepressor 1, Nuclear receptor subfamily 1 group D member 1 著者 Ronin, C, Ciesielski, F, Hegazy, L, Burris, P.T. 登録日 2022-06-08 公開日 2022-12-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.504 Å) 主引用文献 Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB. Nat Commun, 13, 2022
5J8Y	Crystal structure of the Scm-SAM and Sfmbt-SAM heterodimer 分子名称: Polycomb protein Scm, Polycomb protein Sfmbt 著者 Frey, F, Benda, C, Mueller, J. 登録日 2016-04-08 公開日 2016-05-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Molecular basis of PRC1 targeting to Polycomb response elements by PhoRC. Genes Dev., 30, 2016
5Q04	Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-5-chlorothiophen-2-yl)sulfonyl-3-(5-bromo-1,3-thiazol-2-yl)urea 分子名称: 4-bromo-N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-chlorothiophene-2-sulfonamide, Fructose-1,6-bisphosphatase 1 著者 Ruf, A, Joseph, C, Alker, A, Banner, D, Tetaz, T, Benz, J, Kuhn, B, Rudolph, M.G, Yang, H, Shao, C, Burley, S.K. 登録日 2017-04-18 公開日 2019-01-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-5-chlorothiophen-2-yl)sulfonyl-3-(5-bromo-1,3-thiazol-2-yl)urea To be published
5F9B	X-ray crystal structure of PPARgamma in the complex with caulophyllogenin 分子名称: Caulophyllogenin, Peroxisome proliferator-activated receptor gamma 著者 Pochetti, G, Montanari, R, Capelli, D. 登録日 2015-12-09 公開日 2016-06-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Screening of saponins and sapogenins from Medicago species as potential PPAR gamma agonists and X-ray structure of the complex PPAR gamma /caulophyllogenin. Sci Rep, 6, 2016
6VZO	Crystal structure of human PPARgamma ligand binding domain (Protein delipidated by denature and refold) 分子名称: Peroxisome proliferator-activated receptor gamma 著者 Shang, J, Kojetin, D.J. 登録日 2020-02-28 公開日 2021-03-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Structural mechanism underlying ligand binding and activation of PPAR gamma. Structure, 29, 2021
6VZM	Crystal structure of human PPARgamma ligand binding domain Y473E mutant in complex with Darglitazone 分子名称: (5Z)-5-({4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl}methylidene)-1,3-thiazolidine-2,4-dione, Peroxisome proliferator-activated receptor gamma 著者 Shang, J, Kojetin, D.J. 登録日 2020-02-28 公開日 2021-03-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural mechanism underlying ligand binding and activation of PPAR gamma. Structure, 29, 2021
6VZN	Crystal structure of human PPARgamma ligand binding domain Y473E mutant 分子名称: Peroxisome proliferator-activated receptor gamma 著者 Shang, J, Kojetin, D.J. 登録日 2020-02-28 公開日 2021-03-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural mechanism underlying ligand binding and activation of PPAR gamma. Structure, 29, 2021
6VZL	Crystal structure of human PPARgamma ligand binding domain in complex with GW1929 分子名称: (2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, Peroxisome proliferator-activated receptor gamma 著者 Shang, J, Kojetin, D.J. 登録日 2020-02-28 公開日 2021-03-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Structural mechanism underlying ligand binding and activation of PPAR gamma. Structure, 29, 2021
1AII	ANNEXIN III 分子名称: ANNEXIN III, CALCIUM ION, ETHANOLAMINE, ... 著者 Lewit-Bentley, A, Perron, B. 登録日 1996-11-28 公開日 1997-03-12 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Can enzymatic activity, or otherwise, be inferred from structural studies of annexin III? J.Biol.Chem., 272, 1997
3IUQ	apPEP_D622N+PP closed state 分子名称: GLYCEROL, N-BENZYLOXYCARBONYL-L-PROLYL-L-PROLINAL, Prolyl Endopeptidase 著者 Chiu, T.K. 登録日 2009-08-31 公開日 2010-05-05 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Induced-fit mechanism for prolyl endopeptidase J.Biol.Chem., 285, 2010
5PZV	Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromopyridin-2-yl)-3-(4-chlorophenyl)sulfonylurea 分子名称: Fructose-1,6-bisphosphatase 1, N-[(4-bromopyridin-2-yl)carbamoyl]-4-chlorobenzene-1-sulfonamide 著者 Ruf, A, Joseph, C, Alker, A, Banner, D, Tetaz, T, Benz, J, Kuhn, B, Rudolph, M.G, Yang, H, Shao, C, Burley, S.K. 登録日 2017-04-11 公開日 2019-01-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromopyridin-2-yl)-3-(4-chlorophenyl)sulfonylurea To be published
5Q0A	Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-cyanopyrazin-2-yl)-3-[3-(difluoromethoxy)phenyl]sulfonylurea 分子名称: Fructose-1,6-bisphosphatase 1, N-[(5-cyanopyrazin-2-yl)carbamoyl]-3-(difluoromethoxy)benzene-1-sulfonamide 著者 Ruf, A, Joseph, C, Alker, A, Banner, D, Tetaz, T, Benz, J, Kuhn, B, Rudolph, M.G, Yang, H, Shao, C, Burley, S.K. 登録日 2017-04-11 公開日 2019-01-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-cyanopyrazin-2-yl)-3-[3-(difluoromethoxy)phenyl]sulfonylurea To be published
2AHP	GCN4 leucine zipper, mutation of Lys15 to epsilon-azido-Lys 分子名称: General control protein GCN4 著者 Horne, W.S, Ghadiri, M.R. 登録日 2005-07-28 公開日 2006-08-01 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 GCN4 leucine zipper, mutation of Lys15 to epsilon-azido-Lys To be Published
3TQN	Structure of the transcriptional regulator of the GntR family, from Coxiella burnetii. 分子名称: Transcriptional regulator, GntR family 著者 Rudolph, M, Cheung, J, Franklin, M.C, Cassidy, M, Gary, E, Burshteyn, F, Love, J. 登録日 2011-09-09 公開日 2011-09-28 最終更新日 2017-11-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural genomics for drug design against the pathogen Coxiella burnetii. Proteins, 83, 2015
2BZJ	CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU3 分子名称: PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, RUTHENIUM-PYRIDOCARBAZOLE-3 著者 Debreczeni, J.E, Bullock, A, Knapp, S, von Delft, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A. 登録日 2005-08-18 公開日 2005-10-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal Structure of the Human Pim1 in Complex with Ruthenium Organometallic Ligands To be Published
2BZK	CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH AMPPNP AND PIMTIDE 分子名称: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PIMTIDE, PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1 著者 Debreczeni, J.E, Bullock, A, Knapp, S, von Delft, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A. 登録日 2005-08-18 公開日 2005-11-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Crystal Structure of the Human Pim1 in Complex with Amppnp and Pimtide To be Published
2C3I	CRYSTAL STRUCTURE OF HUMAN PIM1 IN COMPLEX WITH IMIDAZOPYRIDAZIN I 分子名称: 1-(3-{6-[(CYCLOPROPYLMETHYL)AMINO]IMIDAZO[1,2-B]PYRIDAZIN-3-YL}PHENYL)ETHANONE, PIMTIDE, PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1 著者 Philippakopoulos, P, Knapp, S, Debreczeni, J, Bullock, A, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Guo, K, Weigelt, J. 登録日 2005-10-07 公開日 2005-11-01 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Analysis Identifies Imidazo[1,2- B]Pyridazines as Pim Kinase Inhibitors with in Vitro Antileukemic Activity. Cancer Res., 67, 2007
2BZI	CRYSTAL STRUCTURE OF THE HUMAN PIM1 IN COMPLEX WITH A RUTHENIUM ORGANOMETALLIC LIGAND RU2 分子名称: PROTO-ONCOGENE SERINE THREONINE PROTEIN KINASE PIM1, RU-PYRIDOCARBAZOLE-2 著者 Debreczeni, J.E, Bullock, A, Knapp, S, von Delft, F, Sundstrom, M, Arrowsmith, C, Weigelt, J, Edwards, A. 登録日 2005-08-18 公開日 2005-12-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of the Human Pim1 in Complex with Ruthenium Organometallic Ligands To be Published
4KRT	X-ray structure of endolysin from clostridium perfringens phage phiSM101 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, Autolytic lysozyme, ... 著者 Kamitori, S, Yoshida, H. 登録日 2013-05-17 公開日 2014-04-02 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 X-ray structure of a novel endolysin encoded by episomal phage phiSM101 of Clostridium perfringens. Mol.Microbiol., 92, 2014
6S8F	Structure of nucleotide-bound Tel1/ATM 分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1,Serine/threonine-protein kinase TEL1 著者 Yates, L.A, Williams, R.M, Ayala, R, Zhang, X. 登録日 2019-07-09 公開日 2019-10-30 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Cryo-EM Structure of Nucleotide-Bound Tel1ATMUnravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations. Structure, 28, 2020

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