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4I1Z

Crystal structure of the monomeric (V948R) form of the gefitinib/erlotinib resistant EGFR kinase domain L858R+T790M

Summary for 4I1Z
Entry DOI10.2210/pdb4i1z/pdb
Related4I20 4I21 4I22 4I23 4I24
DescriptorEpidermal growth factor receptor (2 entities in total)
Functional Keywordskinase domain, phosphotransfer, atp binding, transferase
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
Total number of polymer chains1
Total formula weight37580.45
Authors
Gajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Stewart, A. (deposition date: 2012-11-21, release date: 2013-01-16, Last modification date: 2024-02-28)
Primary citationGajiwala, K.S.,Feng, J.,Ferre, R.,Ryan, K.,Brodsky, O.,Weinrich, S.,Kath, J.C.,Stewart, A.
Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition.
Structure, 21:209-219, 2013
Cited by
PubMed: 23273428
DOI: 10.1016/j.str.2012.11.014
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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