6VZN

Crystal structure of human PPARgamma ligand binding domain Y473E mutant

Summary for 6VZN

Entry DOI	10.2210/pdb6vzn/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma (2 entities in total)
Functional Keywords	nuclear receptors, tzds, drug design, therapeutic targets, translation
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	62830.92
Authors	Shang, J.,Kojetin, D.J. (deposition date: 2020-02-28, release date: 2021-03-03, Last modification date: 2023-10-11)
Primary citation	Shang, J.,Kojetin, D.J. Structural mechanism underlying ligand binding and activation of PPAR gamma. Structure, 29:940-950.e4, 2021 Cited by PubMed: 33713599 DOI: 10.1016/j.str.2021.02.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation