PDB: 243083 件ウェブページステータス検索Chemie searchBIRD

---

7SCK	Cryo-EM structure of the human Exostosin-1 and Exostosin-2 heterodimer in complex with a 7-sugar oligosaccharide acceptor analog 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Exostosin-1, Exostosin-2, ... 著者 Li, H, Li, H. 登録日 2021-09-28 公開日 2022-09-28 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex. Nat.Chem.Biol., 19, 2023
1WNF	Crystal Structure of PH0066 from Pyrococcus horikoshii 分子名称: 1,2-ETHANEDIOL, L-asparaginase 著者 Ihsanawati, Sekine, S, Murayama, K, Sugawara, M, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-08-02 公開日 2005-02-02 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of PH0066 from Pyrococcus horikoshii To be Published
2YD8	Crystal structure of the N-terminal Ig1-2 module of Human Receptor Protein Tyrosine Phosphatase LAR in complex with sucrose octasulphate 分子名称: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE F 著者 Coles, C.H, Shen, Y, Tenney, A.P, Siebold, C, Sutton, G.C, Lu, W, Gallagher, J.T, Jones, E.Y, Flanagan, J.G, Aricescu, A.R. 登録日 2011-03-18 公開日 2011-04-13 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Proteoglycan-Specific Molecular Switch for Rptp Sigma Clustering and Neuronal Extension. Science, 332, 2011
7SCJ	Cryo-EM structure of the human Exostosin-1 and Exostosin-2 heterodimer in complex with a 4-sugar oligosaccharide acceptor analog 分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Exostosin-1, ... 著者 Li, H, Li, H. 登録日 2021-09-28 公開日 2022-09-28 最終更新日 2024-11-20 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis for heparan sulfate co-polymerase action by the EXT1-2 complex. Nat.Chem.Biol., 19, 2023
1JY2	Crystal Structure of the Central Region of Bovine Fibrinogen (E5 fragment) at 1.4 Angstroms Resolution 分子名称: FIBRINOGEN ALPHA CHAIN, FIBRINOGEN BETA CHAIN, FIBRINOGEN GAMMA-B CHAIN 著者 Madrazo, J, Brown, J.H, Litvinovich, S, Dominguez, R, Yakovlev, S, Medved, L, Cohen, C. 登録日 2001-09-10 公開日 2001-10-17 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal structure of the central region of bovine fibrinogen (E5 fragment) at 1.4-A resolution. Proc.Natl.Acad.Sci.USA, 98, 2001
5BYB	Crystal structure of the catalytic domain of human diphosphoinositol pentakisphosphate kinase 2 (PPIP5K2) in complex with ADP and 1,5-(PA)2-IP4 分子名称: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Wang, H, Shears, S.B. 登録日 2015-06-10 公開日 2015-07-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Synthetic tools for studying the chemical biology of InsP8. Chem.Commun.(Camb.), 51, 2015
1SGC	THE 1.8 ANGSTROMS STRUCTURE OF THE COMPLEX BETWEEN CHYMOSTATIN AND STREPTOMYCES GRISEUS PROTEASE A. A MODEL FOR SERINE PROTEASE CATALYTIC TETRAHEDRAL INTERMEDIATES 分子名称: CHYMOSTATIN A, PROTEINASE A 著者 Delbaere, L.T.J, Brayer, G.D. 登録日 1986-04-18 公開日 1986-07-14 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The 1.8 A structure of the complex between chymostatin and Streptomyces griseus protease A. A model for serine protease catalytic tetrahedral intermediates. J.Mol.Biol., 183, 1985
1NLD	FAB FRAGMENT OF A NEUTRALIZING ANTIBODY DIRECTED AGAINST AN EPITOPE OF GP41 FROM HIV-1 分子名称: FAB1583 著者 Davies, C, Beauchamp, J.C, Emery, D, Rawas, A, Muirhead, H. 登録日 1996-07-02 公開日 1996-12-23 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structure of the Fab fragment from a neutralizing monoclonal antibody directed against an epitope of gp41 from HIV-1. Acta Crystallogr.,Sect.D, 53, 1997
3WS8	Crystal structure of PDE10A in complex with a benzimidazole inhibitor 分子名称: 8-methyl-6-[2-(5-methyl-1-phenyl-1H-benzimidazol-2-yl)ethyl]imidazo[1,5-a]pyrimidine, MAGNESIUM ION, ZINC ION, ... 著者 Amano, Y, Honbou, K. 登録日 2014-03-04 公開日 2014-06-04 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Novel benzimidazole derivatives as phosphodiesterase 10A (PDE10A) inhibitors with improved metabolic stability. Bioorg.Med.Chem., 22, 2014
2D1B	Solution RNA structure model of the HIV-1 dimerization initiation site in the kissing-loop dimer 分子名称: RNA 著者 Baba, S, Takahashi, K, Noguchi, S, Takaku, H, Koyanagi, Y, Yamamoto, N, Kawai, G. 登録日 2005-08-15 公開日 2005-11-01 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution RNA structures of the HIV-1 dimerization initiation site in the kissing-loop and extended-duplex dimers. J.Biochem.(Tokyo), 138, 2005
7L8P	Integrin alphaIIbbeta3 in complex with sibrafiban 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Lin, F.-Y, Springer, T.A. 登録日 2020-12-31 公開日 2022-06-15 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.34995365 Å) 主引用文献 A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell, 185, 2022
2YL6	Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis 分子名称: 1,2-ETHANEDIOL, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, BETA-N-ACETYLHEXOSAMINIDASE, ... 著者 Pluvinage, B, Higgins, M.A, Abbott, D.W, Robb, C, Dalia, A.B, Deng, L, Weiser, J.N, Parsons, T.B, Fairbanks, A.J, Vocadlo, D.J, Boraston, A.B. 登録日 2011-05-31 公開日 2011-09-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Inhibition of the Pneumococcal Virulence Factor Strh and Molecular Insights Into N-Glycan Recognition and Hydrolysis. Structure, 19, 2011
5Z1R	Crystal Structure Analysis of the BRD4 分子名称: 1,2-ETHANEDIOL, 5-bromo-N-(2,2-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)-2-methoxybenzene-1-sulfonamide, Bromodomain-containing protein 4, ... 著者 Xu, Y, Zhang, Y, Xiang, Q, Song, M, Wang, C. 登録日 2017-12-28 公開日 2019-01-02 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer. Acs Med.Chem.Lett., 9, 2018
4E3Y	X-ray structure of the Serratia marcescens endonuclease at 0.95 A resolution 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Lashkov, A.A, Balaev, V.V, Gabdoulkhakov, A.G, Betzel, C, Mikhailov, A.M. 登録日 2012-03-11 公開日 2013-05-08 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (0.95 Å) 主引用文献 X-ray structure of the Serratia marcescens endonuclease at 0.95 A resolution To be Published
3KFP	HIV Protease (PR) with inhibitor TL-3 bound, and DMSOs in exo site 分子名称: BETA-MERCAPTOETHANOL, DIMETHYL SULFOXIDE, Protease, ... 著者 Stout, C.D. 登録日 2009-10-27 公開日 2010-02-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Fragment-based screen against HIV protease. Chem.Biol.Drug Des., 75, 2010
5SH0	CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH C2(N(C)c1cc(ccc1N2C)NC(CN([S](=O)(C)=O)c4c3ccccc3ccc4)=O)=O, micromolar IC50=1.2831377 分子名称: MAGNESIUM ION, N-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)-N~2~-(methanesulfonyl)-N~2~-naphthalen-1-ylglycinamide, ZINC ION, ... 著者 Joseph, C, Benz, J, Flohr, A, Brunner, M, Rudolph, M.G. 登録日 2022-02-01 公開日 2022-10-12 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Crystal Structure of a human phosphodiesterase 10 complex To be published
4GMC	Crystal structure of HCV NS5B polymerase in complex with a thumb inhibitor 分子名称: 3-cyclohexyl-2-(furan-3-yl)-1-[2-(morpholin-4-yl)-2-oxoethyl]-N-(phenylsulfonyl)-1H-indole-6-carboxamide, NS5B polymerase, SULFATE ION 著者 Coulombe, R. 登録日 2012-08-15 公開日 2013-02-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Allosteric N-acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase - Acylsulfonamides and acylsulfamides as carboxylic acid replacements Can.J.Chem., 91, 2013
4MBH	Penam sulfone PSR-3-226 bound to E166A variant of SHV-1 beta-lactamase 分子名称: 3-(formylamino)-L-alanine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-lactamase SHV-1, ... 著者 Rodkey, E.A, van den Akker, F. 登録日 2013-08-19 公開日 2014-07-30 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.22 Å) 主引用文献 Penam sulfones and beta-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition. Plos One, 9, 2014
1K33	Crystal structure analysis of the gp41 core mutant 分子名称: Transmembrane glycoprotein GP41 著者 Shu, W, Lu, M. 登録日 2001-10-01 公開日 2001-10-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Interhelical interactions in the gp41 core: implications for activation of HIV-1 membrane fusion. Biochemistry, 41, 2002
3R30	MK2 kinase bound to Compound 2 分子名称: 1-(2-aminoethyl)-3-[2-(quinolin-3-yl)pyridin-4-yl]-1H-pyrazole-5-carboxylic acid, MAP kinase-activated protein kinase 2 著者 Oubrie, A, Fisher, M. 登録日 2011-03-15 公開日 2011-05-25 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure-based lead identification of ATP-competitive MK2 inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
3OAB	Mint deletion mutant of heterotetrameric geranyl pyrophosphate synthase in complex with ligands 分子名称: 1,2-ETHANEDIOL, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, DIMETHYLALLYL S-THIOLODIPHOSPHATE, ... 著者 Hsieh, F.-L, Chang, T.-H, Ko, T.-P, Wang, A.H.-J. 登録日 2010-08-05 公開日 2010-11-03 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Enhanced specificity of mint geranyl pyrophosphate synthase by modifying the R-loop interactions J.Mol.Biol., 404, 2010
3WUX	Crystal structure of unsaturated glucuronyl hydrolase mutant D115N/K370S from Streptococcus agalactiae 分子名称: 1,2-ETHANEDIOL, Unsaturated chondroitin disaccharide hydrolase 著者 Nakamichi, Y, Oiki, S, Mikami, B, Murata, K, Hashimoto, W. 登録日 2014-05-08 公開日 2014-05-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.792 Å) 主引用文献 Crystal structure of unsaturated glucuronyl hydrolase mutant D115N/K370S from Streptococcus agalactiae to be published
4YP8	Irak4-inhibitor co-structure 分子名称: Interleukin-1 receptor-associated kinase 4, N-{1-(4-cyclopropyl-2-fluorophenyl)-3-[1-(propan-2-yl)piperidin-4-yl]-1H-pyrazol-5-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide 著者 Fischmann, T.O. 登録日 2015-03-12 公開日 2015-05-20 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.641 Å) 主引用文献 Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation. Acs Med.Chem.Lett., 6, 2015
4FVA	Crystal structure of truncated Caenorhabditis elegans TDP2 分子名称: 1,2-ETHANEDIOL, 5'-tyrosyl-DNA phosphodiesterase, MAGNESIUM ION, ... 著者 Shi, K, Kurahashi, K, Aihara, H. 登録日 2012-06-29 公開日 2012-10-31 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2. Nat.Struct.Mol.Biol., 19, 2012
1WUG	complex structure of PCAF bromodomain with small chemical ligand NP1 分子名称: Histone acetyltransferase PCAF, N-(3-AMINOPROPYL)-4-METHYL-2-NITROBENZENAMINE 著者 Zeng, L, Li, J, Muller, M, Yan, S, Mujtaba, S, Pan, C, Wang, Z, Zhou, M.M. 登録日 2004-12-07 公開日 2005-08-16 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Selective small molecules blocking HIV-1 Tat and coactivator PCAF association J.Am.Chem.Soc., 127, 2005

<1120112111221123112411251126112711281129113011311132113311341135>