3JSS
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2XP2
| Structure of the Human Anaplastic Lymphoma Kinase in Complex with Crizotinib (PF-02341066) | 分子名称: | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, TYROSINE-PROTEIN KINASE RECEPTOR | 著者 | McTigue, M, Deng, Y, Liu, W, Brooun, A, Timofeevski, S, Marrone, T, Cui, J.J. | 登録日 | 2010-08-24 | 公開日 | 2010-09-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure Based Drug Design of Crizotinib (Pf-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal-Epithelial Transition Factor (C-met) Kinase and Anaplastic Lymphoma Kinase (Alk). J.Med.Chem, 54, 2011
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3R02
| The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors | 分子名称: | 7-[(cis-4-aminocyclohexyl)amino]-5-bromo-1-benzofuran-2-carboxylic acid, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase pim-1 | 著者 | Xiang, Y, Hirth, B, Asmussen, G, Biemann, H.-P, Good, A, Fitzgerald, M, Gladysheva, T, Jancsics, K, Liu, J, Metz, M, Papoulis, A, Skerlj, R, Stepp, D.J, Wei, R.R. | 登録日 | 2011-03-07 | 公開日 | 2011-05-11 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors. Bioorg.Med.Chem.Lett., 21, 2011
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2A6Q
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7BL1
| human complex II-BATS bound to membrane-attached Rab5a-GTP | 分子名称: | Beclin-1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Tremel, S, Morado, D.R, Kovtun, O, Williams, R.L, Briggs, J.A.G, Munro, S, Ohashi, Y, Bertram, J, Perisic, O. | 登録日 | 2021-01-17 | 公開日 | 2021-03-03 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (9.8 Å) | 主引用文献 | Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes. Nat Commun, 12, 2021
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2ZH6
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2ZDU
| Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor | 分子名称: | 4-[(4-{[6-bromo-3-(methoxycarbonyl)-1-oxo-4-phenylisoquinolin-2(1H)-yl]methyl}phenyl)amino]-4-oxobutanoic acid, Mitogen-activated protein kinase 10 | 著者 | Sogabe, S, Ohra, T, Itoh, F, Habuka, N, Fujishima, A. | 登録日 | 2007-11-27 | 公開日 | 2008-09-23 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1) Bioorg.Med.Chem., 16, 2008
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2ZH4
| Complex structure of AFCCA with tRNAminiDCG | 分子名称: | CCA-adding enzyme, SULFATE ION, tRNA (34-MER) | 著者 | Toh, Y, Tomita, K. | 登録日 | 2008-02-01 | 公開日 | 2008-08-05 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Molecular basis for maintenance of fidelity during the CCA-adding reaction by a CCA-adding enzyme Embo J., 27, 2008
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5YXJ
| FXR ligand binding domain | 分子名称: | 2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate, Bile acid receptor, Peptide from Nuclear receptor coactivator 2 | 著者 | Yi, L, Yong, L. | 登録日 | 2017-12-05 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | 主引用文献 | A ligand of drug binding to FXR To Be Published
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7BU5
| Crystal Structure of Human SLX4 and MUS81 | 分子名称: | GLYCINE, MUS81 endonuclease homolog (Yeast), isoform CRA_b, ... | 著者 | Wan, B, Wu, J, Lei, M. | 登録日 | 2020-04-04 | 公開日 | 2021-04-07 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | SLX4 control MUS81 endonuclease function in telomere through an intermolecular SAP domain To be published
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2LBD
| LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO ALL-TRANS RETINOIC ACID | 分子名称: | RETINOIC ACID, RETINOIC ACID RECEPTOR GAMMA | 著者 | Renaud, J.-P, Rochel, N, Ruff, M, Moras, D, Structural Proteomics in Europe (SPINE) | 登録日 | 1997-08-19 | 公開日 | 1997-11-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. Nature, 378, 1995
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2Z47
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5T7B
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8HHP
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3JBO
| Cryo-electron microscopy reconstruction of the Plasmodium falciparum 80S ribosome bound to P/E-tRNA | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein eS1, ... | 著者 | Sun, M, Li, W, Blomqvist, K, Das, S, Hashem, Y, Dvorin, J.D, Frank, J. | 登録日 | 2015-09-16 | 公開日 | 2015-10-14 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | 主引用文献 | Dynamical features of the Plasmodium falciparum ribosome during translation. Nucleic Acids Res., 43, 2015
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8RGQ
| Open Complex I from murine liver | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Vercellino, I, Sazanov, L.A. | 登録日 | 2023-12-14 | 公開日 | 2024-04-24 | 最終更新日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | SCAF1 drives the compositional diversity of mammalian respirasomes. Nat.Struct.Mol.Biol., 31, 2024
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2XO2
| Human Annexin V with incorporated Methionine analogue Azidohomoalanine | 分子名称: | ANNEXIN A5, CALCIUM ION, CHLORIDE ION, ... | 著者 | Debela, M, Merkel, L, Goettig, P, Budisa, N. | 登録日 | 2010-08-09 | 公開日 | 2011-08-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Non-Canonical Amino Acids for Click Chemistry Reactions Incorporated in Human Annexin V To be Published
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3JYA
| Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors | 分子名称: | 6,9-dichloro[1]benzothieno[3,2-d]pyrimidin-4(3H)-one, Proto-oncogene serine/threonine-protein kinase Pim-1 | 著者 | Stoll, V.S. | 登録日 | 2009-09-21 | 公開日 | 2009-11-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors TO BE PUBLISHED
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8RGT
| Open Complex I from murine brain | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Vercellino, I, Sazanov, L.A. | 登録日 | 2023-12-14 | 公開日 | 2024-04-24 | 最終更新日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | SCAF1 drives the compositional diversity of mammalian respirasomes. Nat.Struct.Mol.Biol., 31, 2024
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8RGR
| Closed Complex I from murine liver | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Vercellino, I, Sazanov, L.A. | 登録日 | 2023-12-14 | 公開日 | 2024-04-24 | 最終更新日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | SCAF1 drives the compositional diversity of mammalian respirasomes. Nat.Struct.Mol.Biol., 31, 2024
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2OI4
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1NNL
| Crystal structure of Human Phosphoserine Phosphatase | 分子名称: | CALCIUM ION, CHLORIDE ION, L-3-phosphoserine phosphatase | 著者 | Peeraer, Y, Rabijns, A, Verboven, C, Collet, J.F, Van Schaftingen, E, De Ranter, C. | 登録日 | 2003-01-14 | 公開日 | 2003-06-03 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | High-resolution structure of human phosphoserine phosphatase in open conformation. Acta Crystallogr.,Sect.D, 59, 2003
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8QXJ
| Cryo-EM structure of tetrameric human SAMHD1 with dApNHpp | 分子名称: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... | 著者 | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | 登録日 | 2023-10-24 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
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8QXL
| Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, ... | 著者 | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | 登録日 | 2023-10-24 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
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8QXM
| Cryo-EM structure of tetrameric human SAMHD1 State III - Relaxed | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | 著者 | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | 登録日 | 2023-10-24 | 公開日 | 2024-05-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis. Nat Commun, 15, 2024
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