8HHP
Crystal structure of PPARg-LBD complexed with three partial agonists, one nTZDpa and two LT175
Summary for 8HHP
Entry DOI | 10.2210/pdb8hhp/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID, (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid, ... (4 entities in total) |
Functional Keywords | pparg-lbd, partial agonists, ntzdpa, lt175, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 32514.58 |
Authors | Kojima, H.,Itoh, T. (deposition date: 2022-11-16, release date: 2023-11-22, Last modification date: 2024-05-22) |
Primary citation | Kojima, H.,Yanagi, R.,Higuchi, E.,Yoshizawa, M.,Shimodaira, T.,Kumagai, M.,Kyoya, T.,Sekine, M.,Egawa, D.,Ohashi, N.,Ishida, H.,Yamamoto, K.,Itoh, T. Covalent Modifier Discovery Using Hydrogen/Deuterium Exchange-Mass Spectrometry. J.Med.Chem., 66:4827-4839, 2023 Cited by PubMed: 36994595DOI: 10.1021/acs.jmedchem.2c01986 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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