8HHP

Crystal structure of PPARg-LBD complexed with three partial agonists, one nTZDpa and two LT175

Summary for 8HHP

• Entry DOI: 10.2210/pdb8hhp/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID, (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid, ... (4 entities in total)
• Functional Keywords: pparg-lbd, partial agonists, ntzdpa, lt175, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 32514.58

Authors

Kojima, H.,Itoh, T. (deposition date: 2022-11-16, release date: 2023-11-22)

• Primary citation: Kojima, H.,Yanagi, R.,Higuchi, E.,Yoshizawa, M.,Shimodaira, T.,Kumagai, M.,Egawa, D.,Ohashi, N.,Ishida, H.,Yamamoto, K.,Itoh, T.; Covalent Modifier Discovery by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS); To Be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)