2ZDU

Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor

Summary for 2ZDU

Entry DOI	10.2210/pdb2zdu/pdb
Related	2ZDT
Descriptor	Mitogen-activated protein kinase 10, 4-[(4-{[6-bromo-3-(methoxycarbonyl)-1-oxo-4-phenylisoquinolin-2(1H)-yl]methyl}phenyl)amino]-4-oxobutanoic acid (3 entities in total)
Functional Keywords	protein kinase, alternative splicing, atp-binding, chromosomal rearrangement, cytoplasm, epilepsy, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P53779
Total number of polymer chains	1
Total formula weight	42623.07
Authors	Sogabe, S.,Ohra, T.,Itoh, F.,Habuka, N.,Fujishima, A. (deposition date: 2007-11-27, release date: 2008-09-23, Last modification date: 2023-11-01)
Primary citation	Asano, Y.,Kitamura, S.,Ohra, T.,Aso, K.,Igata, H.,Tamura, T.,Kawamoto, T.,Tanaka, T.,Sogabe, S.,Matsumoto, S.,Yamaguchi, M.,Kimura, H.,Itoh, F. Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1) Bioorg.Med.Chem., 16:4715-4732, 2008 Cited by PubMed: 18313304 DOI: 10.1016/j.bmc.2008.02.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation