2ZDU

Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase 10	polymer	364	42059.7	1	UniProt (P53779) Pfam (PF00069) In PDB	Homo sapiens (human)	Stress-activated protein kinase JNK3, c-Jun N-terminal kinase 3, MAP kinase p49 3F12
2	A	4-[(4-{[6-bromo-3-(methoxycarbonyl)-1-oxo-4-phenylisoquinolin-2(1H)-yl]methyl}phenyl)amino]-4-oxobutanoic acid	non-polymer		563.4	1	Chemie (446)
3		water	water		18.0	58	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42059.7
Non-Polymers*	Number of molecules	1
	Total formula weight	563.4
All*	Total formula weight	42623.1

*Water molecules are not included.