2ZDT
Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor
Summary for 2ZDT
Entry DOI | 10.2210/pdb2zdt/pdb |
Related | 2ZDU |
Descriptor | Mitogen-activated protein kinase 10, 4-[(6-chloro-1-oxo-4-phenyl-3-propanoylisoquinolin-2(1H)-yl)methyl]benzoic acid, GLYCEROL, ... (4 entities in total) |
Functional Keywords | protein kinase, atp-binding, epilepsy, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P53779 |
Total number of polymer chains | 1 |
Total formula weight | 42597.66 |
Authors | Sogabe, S.,Asano, Y.,Fukumoto, S.,Habuka, N.,Fujishima, A. (deposition date: 2007-11-27, release date: 2008-09-23, Last modification date: 2023-11-01) |
Primary citation | Asano, Y.,Kitamura, S.,Ohra, T.,Itoh, F.,Kajino, M.,Tamura, T.,Kaneko, M.,Ikeda, S.,Igata, H.,Kawamoto, T.,Sogabe, S.,Matsumoto, S.,Tanaka, T.,Yamaguchi, M.,Kimura, H.,Fukumoto, S. Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2) Bioorg.Med.Chem., 16:4699-4714, 2008 Cited by PubMed: 18313930DOI: 10.1016/j.bmc.2008.02.028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report