6YM9
| Mycobacterium tuberculosis FtsZ in complex with GTP-gamma-S | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Cell division protein FtsZ | 著者 | Alnami, A.T, Norton, R.S, Pena, H.P, Haider, M, kozielski, F. | 登録日 | 2020-04-08 | 公開日 | 2021-04-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Conformational Flexibility of A Highly Conserved Helix Controls Cryptic Pocket Formation in FtsZ. J.Mol.Biol., 433, 2021
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6Y1U
| Mycobacterium tuberculosis FtsZ-GDP in complex with 4-hydroxycoumarin | 分子名称: | 4-HYDROXY-2H-CHROMEN-2-ONE, Cell division protein FtsZ, DIMETHYL SULFOXIDE, ... | 著者 | Alnami, A.T, Norton, R.S, Pena, H.P, Haider, M, kozielski, F. | 登録日 | 2020-02-13 | 公開日 | 2021-06-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Conformational Flexibility of A Highly Conserved Helix Controls Cryptic Pocket Formation in FtsZ. J.Mol.Biol., 433, 2021
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6Y1V
| Mycobacterium tuberculosis FtsZ-GTP-gamma-S in complex with 4-hydroxycoumarin | 分子名称: | 4-HYDROXY-2H-CHROMEN-2-ONE, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Cell division protein FtsZ, ... | 著者 | Alnami, A.T, Norton, R.S, Pena, H.P, Haider, M, kozielski, F. | 登録日 | 2020-02-13 | 公開日 | 2021-06-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Conformational Flexibility of A Highly Conserved Helix Controls Cryptic Pocket Formation in FtsZ. J.Mol.Biol., 433, 2021
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3I55
| Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit | 分子名称: | 23S ribosomal RNA, 50S ribosomal protein L10E, 50S ribosomal protein L10e, ... | 著者 | Gurel, G, Blaha, G, Steitz, T.A, Moore, P.B. | 登録日 | 2009-07-03 | 公開日 | 2010-03-09 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui. Antimicrob.Agents Chemother., 53, 2009
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8J0T
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in the apo-form | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | 著者 | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | 登録日 | 2023-04-11 | 公開日 | 2024-05-22 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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8J0S
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in complex with bedaquiline(BDQ) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase epsilon chain, ... | 著者 | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | 登録日 | 2023-04-11 | 公開日 | 2024-05-22 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (2.58 Å) | 主引用文献 | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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8JR0
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in complex with TBAJ-587 | 分子名称: | (1~{S},2~{S})-1-(6-bromanyl-2-methoxy-quinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2-fluoranyl-3-methoxy-phenyl)butan-2-ol, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | 登録日 | 2023-06-15 | 公開日 | 2024-05-01 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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6YT1
| Mtb TMK crystal structure in complex with compound 26 | 分子名称: | 2-ethyl-~{N}-[[4-[4-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]piperidin-1-yl]phenyl]methyl]-1,2,3,5,6,7,8,8~{a}-octahydroimidazo[1,2-a]pyridine-3-carboxamide, CITRIC ACID, Thymidylate kinase | 著者 | Merceron, R, De Munck, S, Jian, Y, Munier-Lehmann, H, Van Calenbergh, S, Savvides, S.N. | 登録日 | 2020-04-23 | 公開日 | 2020-09-02 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. Eur.J.Med.Chem., 206, 2020
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6VVY
| Mycobacterium tuberculosis WT RNAP transcription open promoter complex with Sorangicin | 分子名称: | DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. | 登録日 | 2020-02-18 | 公開日 | 2020-10-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ZA4
| M. tuberculosis salicylate synthase MbtI in complex with 5-(3-cyanophenyl)furan-2-carboxylate | 分子名称: | 5-(3-cyanophenyl)furan-2-carboxylic acid, CHLORIDE ION, Salicylate synthase | 著者 | Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M. | 登録日 | 2020-06-04 | 公開日 | 2020-07-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | 主引用文献 | Shedding X-ray Light on the Role of Magnesium in the Activity ofMycobacterium tuberculosisSalicylate Synthase (MbtI) for Drug Design. J.Med.Chem., 63, 2020
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6ZA6
| M. tuberculosis salicylate synthase MbtI in complex with Ba2+ | 分子名称: | BARIUM ION, CHLORIDE ION, GLYCEROL, ... | 著者 | Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M. | 登録日 | 2020-06-04 | 公開日 | 2020-07-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.804 Å) | 主引用文献 | Shedding X-ray Light on the Role of Magnesium in the Activity ofMycobacterium tuberculosisSalicylate Synthase (MbtI) for Drug Design. J.Med.Chem., 63, 2020
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6ZA5
| M. tuberculosis salicylate synthase MbtI in complex with salicylate and Mg2+ | 分子名称: | 2-HYDROXYBENZOIC ACID, ACETATE ION, MAGNESIUM ION, ... | 著者 | Mori, M, Villa, S, Meneghetti, F, Bellinzoni, M. | 登録日 | 2020-06-04 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.109 Å) | 主引用文献 | Shedding X-ray Light on the Role of Magnesium in the Activity ofMycobacterium tuberculosisSalicylate Synthase (MbtI) for Drug Design. J.Med.Chem., 63, 2020
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6VW0
| Mycobacterium tuberculosis RNAP S456L mutant open promoter complex | 分子名称: | DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. | 登録日 | 2020-02-18 | 公開日 | 2020-10-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
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7NVH
| Cryo-EM structure of the mycolic acid transporter MmpL3 from M. tuberculosis | 分子名称: | Lauryl Maltose Neopentyl Glycol, Trehalose monomycolate exporter MmpL3 | 著者 | Adams, O, Deme, J.C, Parker, J.L, Lea, S.M, Newstead, S. | 登録日 | 2021-03-15 | 公開日 | 2021-06-16 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target. Structure, 29, 2021
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6VVZ
| Mycobacterium tuberculosis RNAP S456L mutant transcription initiation intermediate structure with Sorangicin | 分子名称: | DNA (62-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... | 著者 | Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. | 登録日 | 2020-02-18 | 公開日 | 2020-10-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
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7NPH
| Crystal structure of Mycobacterium tuberculosis ArgC in complex with 5-methoxy-1,3-benzoxazole-2-carboxylic acid | 分子名称: | 5-methoxy-1,3-benzoxazole-2-carboxylic acid, N-acetyl-gamma-glutamyl-phosphate reductase, PHOSPHATE ION | 著者 | Gupta, P, Mendes, V, Blundell, T.L. | 登録日 | 2021-02-26 | 公開日 | 2021-06-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis Comput Struct Biotechnol J, 19, 2021
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7NPJ
| Crystal structure of Mycobacterium tuberculosis ArgC in complex with 6-phenoxy-3-pyridinamine | 分子名称: | 6-phenoxy-3-pyridinamine, N-acetyl-gamma-glutamyl-phosphate reductase | 著者 | Gupta, P, Mendes, V, Blundell, T.L. | 登録日 | 2021-02-27 | 公開日 | 2021-06-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | 主引用文献 | A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis Comput Struct Biotechnol J, 19, 2021
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1NSG
| THE STRUCTURE OF THE IMMUNOPHILIN-IMMUNOSUPPRESSANT FKBP12-RAPAMYCIN COMPLEX INTERACTING WITH HUMAN FRAP | 分子名称: | C49-METHYL RAPAMYCIN, FK506-BINDING PROTEIN, FKBP-RAPAMYCIN ASSOCIATED PROTEIN (FRAP) | 著者 | Liang, J, Choi, J, Clardy, J. | 登録日 | 1997-07-01 | 公開日 | 1998-03-18 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. Acta Crystallogr.,Sect.D, 55, 1999
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8J5R
| Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the resting state | 分子名称: | IRON/SULFUR CLUSTER, Putative peptide transport permease protein Rv1282c, Putative peptide transport permease protein Rv1283c, ... | 著者 | Yang, X, Hu, T, Zhang, B, Rao, Z. | 登録日 | 2023-04-24 | 公開日 | 2024-04-03 | 最終更新日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | 主引用文献 | An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality. Nat.Struct.Mol.Biol., 31, 2024
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8J5Q
| Cryo-EM structure of Mycobacterium tuberculosis OppABCD in the pre-translocation state | 分子名称: | Endogenous oligopeptide, IRON/SULFUR CLUSTER, Putative peptide transport permease protein Rv1282c, ... | 著者 | Yang, X, Hu, T, Zhang, B, Rao, Z. | 登録日 | 2023-04-24 | 公開日 | 2024-04-03 | 最終更新日 | 2024-07-31 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality. Nat.Struct.Mol.Biol., 31, 2024
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8J58
| Cryo-EM structure of Mycobacterium tuberculosis ATP synthase Fo in the apo-form | 分子名称: | ATP synthase subunit a, ATP synthase subunit c | 著者 | Zhang, Y, Lai, Y, Liu, F, Rao, Z, Gong, H. | 登録日 | 2023-04-21 | 公開日 | 2024-05-01 | 最終更新日 | 2024-08-21 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631, 2024
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7PQH
| Cryo-EM structure of Saccharomyces cerevisiae TOROID (TORC1 Organized in Inhibited Domains). | 分子名称: | Serine/threonine-protein kinase TOR2, Target of rapamycin complex 1 subunit KOG1,Target of rapamycin complex 1 subunit Kog1, Target of rapamycin complex subunit LST8 | 著者 | Felix, J, Prouteau, M, Bourgoint, C, Bonadei, L, Desfosses, A, Gabus, C, Sadian, Y, Savvides, S.N, Gutsche, I, Loewith, R. | 登録日 | 2021-09-17 | 公開日 | 2023-01-18 | 最終更新日 | 2023-03-29 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | EGOC inhibits TOROID polymerization by structurally activating TORC1. Nat.Struct.Mol.Biol., 30, 2023
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6CJ4
| CRYSTAL STRUCTURE OF PROTEIN CITE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MAGNESIUM AND ACETOACETATE | 分子名称: | ACETATE ION, ACETOACETIC ACID, Citrate lyase subunit beta-like protein, ... | 著者 | Fedorov, A.A, Fedorov, E.V, Wang, H, Bonanno, J.B, Carvalho, L, Almo, S.C. | 登録日 | 2018-02-26 | 公開日 | 2018-08-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | An essential bifunctional enzyme inMycobacterium tuberculosisfor itaconate dissimilation and leucine catabolism. Proc.Natl.Acad.Sci.USA, 116, 2019
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6CHU
| CRYSTAL STRUCTURE OF PROTEIN CITE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MAGNESIUM AND ACETATE | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Citrate lyase subunit beta-like protein, ... | 著者 | Fedorov, A.A, Fedorov, E.V, Wang, H, Bonanno, J.B, Carvalho, L, Almo, S.C. | 登録日 | 2018-02-23 | 公開日 | 2018-08-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | 主引用文献 | An essential bifunctional enzyme inMycobacterium tuberculosisfor itaconate dissimilation and leucine catabolism. Proc.Natl.Acad.Sci.USA, 116, 2019
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6CJ3
| CRYSTAL STRUCTURE OF PROTEIN CITE FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH MAGNESIUM AND PYRUVATE | 分子名称: | ACETATE ION, Citrate lyase subunit beta-like protein, MAGNESIUM ION, ... | 著者 | Fedorov, E.V, Fedorov, A.A, Wang, H, Bonanno, J.B, Carvalho, L, Almo, S.C. | 登録日 | 2018-02-26 | 公開日 | 2018-08-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | An essential bifunctional enzyme inMycobacterium tuberculosisfor itaconate dissimilation and leucine catabolism. Proc.Natl.Acad.Sci.USA, 116, 2019
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