8J0S

Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in complex with bedaquiline(BDQ)

Summary for 8J0S

Entry DOI	10.2210/pdb8j0s/pdb
EMDB information	35909
Descriptor	ATP synthase subunit a, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ... (12 entities in total)
Functional Keywords	atp synthase, mycobacterium tuberculosis, cryo-em, membrane protein
Biological source	Mycobacterium tuberculosis More
Total number of polymer chains	20
Total formula weight	558218.76
Authors	Zhang, Y.,Lai, Y.,Liu, F.,Rao, Z.,Gong, H. (deposition date: 2023-04-11, release date: 2024-05-22, Last modification date: 2024-08-21)
Primary citation	Zhang, Y.,Lai, Y.,Zhou, S.,Ran, T.,Zhang, Y.,Zhao, Z.,Feng, Z.,Yu, L.,Xu, J.,Shi, K.,Wang, J.,Pang, Y.,Li, L.,Chen, H.,Guddat, L.W.,Gao, Y.,Liu, F.,Rao, Z.,Gong, H. Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587. Nature, 631:409-414, 2024 Cited by PubMed: 38961288 DOI: 10.1038/s41586-024-07605-8 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.58 Å)

Structure validation