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8WBH
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CryoEM structure of non-structural protein 1 tetramer from Japanese encephalitis virus
分子名称: Genome polyprotein
著者Jiao, H.Z, Pan, Q, Hu, H.L.
登録日2023-09-09
公開日2024-05-22
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献The step-by-step assembly mechanism of secreted flavivirus NS1 tetramer and hexamer captured at atomic resolution.
Sci Adv, 10, 2024
8WBE
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CryoEM structure of non-structural protein 1 hexamer 2 from dengue virus type 4
分子名称: Non-structural protein 1
著者Jiao, H.Z, Pan, Q, Hu, H.L.
登録日2023-09-09
公開日2024-05-22
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献The step-by-step assembly mechanism of secreted flavivirus NS1 tetramer and hexamer captured at atomic resolution.
Sci Adv, 10, 2024
8WBF
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BU of 8wbf by Molmil
CryoEM structure of non-structural protein 1 tetramer from ZIKA virus
分子名称: Genome polyprotein
著者Jiao, H.Z, Pan, Q, Hu, H.L.
登録日2023-09-09
公開日2024-05-22
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献The step-by-step assembly mechanism of secreted flavivirus NS1 tetramer and hexamer captured at atomic resolution.
Sci Adv, 10, 2024
8WBG
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BU of 8wbg by Molmil
CryoEM structure of non-structural protein 1 tetramer from ZIKA virus
分子名称: Genome polyprotein
著者Jiao, H.Z, Pan, Q, Hu, H.L.
登録日2023-09-09
公開日2024-05-22
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献The step-by-step assembly mechanism of secreted flavivirus NS1 tetramer and hexamer captured at atomic resolution.
Sci Adv, 10, 2024
8WBB
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BU of 8wbb by Molmil
CryoEM structure of non-structural protein 1 dimer from dengue virus type 4
分子名称: Genome polyprotein
著者Jiao, H.Z, Pan, Q, Hu, H.L.
登録日2023-09-09
公開日2024-05-22
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献The step-by-step assembly mechanism of secreted flavivirus NS1 tetramer and hexamer captured at atomic resolution.
Sci Adv, 10, 2024
5YAZ
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BU of 5yaz by Molmil
Crystal structure of the ANKRD domain of KANK1
分子名称: ACETATE ION, KN motif and ankyrin repeat domains 1
著者Wei, Z, Pan, W.
登録日2017-09-02
公開日2017-12-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural insights into ankyrin repeat-mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion.
J. Biol. Chem., 293, 2018
5YAY
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BU of 5yay by Molmil
Crystal structure of KANK1/KIF21A complex
分子名称: KN motif and ankyrin repeat domains 1, Kinesin-like protein KIF21A
著者Wei, Z, Pan, W.
登録日2017-09-02
公開日2017-12-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structural insights into ankyrin repeat-mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion.
J. Biol. Chem., 293, 2018
6ISU
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BU of 6isu by Molmil
Crystal structure of Lys27-linked di-ubiquitin in complex with its selective interacting protein UCHL3
分子名称: Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L3
著者Ding, S, Pan, M, Zheng, Q, Ren, Y, Hong, D.
登録日2018-11-19
公開日2019-02-06
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.866 Å)
主引用文献Chemical Protein Synthesis Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains.
Angew. Chem. Int. Ed. Engl., 58, 2019
7D5L
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BU of 7d5l by Molmil
Discovery of BMS-986144, a Third Generation, Pan Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
分子名称: NS3/4A Protease, ZINC ION, [1,1,1-tris(fluoranyl)-2-methyl-propan-2-yl] ~{N}-[(1~{S},4~{R},6~{S},7~{Z},11~{R},13~{R},14~{S},18~{R})-13-ethyl-18-(7-fluoranyl-6-methoxy-isoquinolin-1-yl)oxy-11-methyl-4-[(1-methylcyclopropyl)sulfonylcarbamoyl]-2,15-bis(oxidanylidene)-3,16-diazatricyclo[14.3.0.0^{4,6}]nonadec-7-en-14-yl]carbamate
著者Ghosh, K, Anumula, R, Kumar, A.
登録日2020-09-26
公開日2020-12-16
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Discovery of BMS-986144, a Third-Generation, Pan-Genotype NS3/4A Protease Inhibitor for the Treatment of Hepatitis C Virus Infection.
J.Med.Chem., 63, 2020
8GUE
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BU of 8gue by Molmil
Crystal Structure of narbomycin-bound cytochrome P450 PikC with the unnatural amino acid p-Acetyl-L-Phenylalanine incorporated at position 238
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cytochrome P450 monooxygenase PikC, ...
著者Li, G.B, Pan, Y.J, Li, S.Y, Gao, X.
登録日2022-09-11
公開日2023-02-15
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Unnatural activities and mechanistic insights of cytochrome P450 PikC gained from site-specific mutagenesis by non-canonical amino acids.
Nat Commun, 14, 2023
6VYH
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BU of 6vyh by Molmil
Cryo-EM structure of SLC40/ferroportin in complex with Fab
分子名称: 11F9 heavy-chain, 11F9 light-chain, COBALT (II) ION, ...
著者Shen, J, Ren, Z, Pan, Y, Gao, S, Yan, N, Zhou, M.
登録日2020-02-26
公開日2020-11-11
最終更新日2022-09-28
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of ion transport and inhibition in ferroportin.
Nat Commun, 11, 2020
6W90
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De novo designed NTF2 fold protein NT-9
分子名称: 1,2-Distearoyl-sn-glycerophosphoethanolamine, NTF2 fold protein loop-helix-loop design NT-9
著者Thompson, M.C, Pan, X, Liu, L, Fraser, J.S, Kortemme, T.
登録日2020-03-21
公開日2020-08-19
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Expanding the space of protein geometries by computational design of de novo fold families.
Science, 369, 2020
6WIK
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BU of 6wik by Molmil
Cryo-EM structure of SLC40/ferroportin with Fab in the presence of hepcidin
分子名称: 11F9 Fab heavy-chain, 11F9 Fab light-chain, Solute carrier family 40 protein
著者Shen, J, Ren, Z, Pan, Y, Gao, S, Yan, N, Zhou, M.
登録日2020-04-10
公開日2020-11-11
最終更新日2022-08-31
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural basis of ion transport and inhibition in ferroportin.
Nat Commun, 11, 2020
8ONV
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BU of 8onv by Molmil
KRAS-G13D in complex with BI-2493
分子名称: (7~{S})-2'-azanyl-3-[2-[(2~{S})-2-methylpiperazin-1-yl]pyrimidin-4-yl]spiro[5,6-dihydro-4~{H}-1,2-benzoxazole-7,4'-6,7-dihydro-5~{H}-1-benzothiophene]-3'-carbonitrile, 1,2-ETHANEDIOL, GTPase KRas, ...
著者Boettcher, J, Herdeis, L.
登録日2023-04-04
公開日2023-06-07
最終更新日2023-07-19
実験手法X-RAY DIFFRACTION (1.01 Å)
主引用文献Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
Nature, 619, 2023
7M8L
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EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Virion spike glycoprotein 1, ...
著者Murin, C.D, Ward, A.B.
登録日2021-03-30
公開日2021-11-10
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Pan-ebolavirus protective therapy by two multifunctional human antibodies.
Cell, 184, 2021
7E9Q
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BU of 7e9q by Molmil
Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(1 out RBD, state3)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 35B5 Fab, Light chain of 35B5 Fab, ...
著者Wang, X.F, Zhu, Y.Q.
登録日2021-03-04
公開日2022-03-09
最終更新日2022-09-21
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Signal Transduct Target Ther, 7, 2022
7E9O
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Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(3 up RBDs, state2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 35B5 Fab, Light chain of 35B5 Fab, ...
著者Wang, X.F, Zhu, Y.Q.
登録日2021-03-04
公開日2022-03-09
最終更新日2022-09-21
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Signal Transduct Target Ther, 7, 2022
7E9P
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BU of 7e9p by Molmil
Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(state2, local refinement of the RBD and 35B5 Fab)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 35B5 Fab, Light chain of 35B5 Fab, ...
著者Wang, X.F, Zhu, Y.Q.
登録日2021-03-04
公開日2022-03-23
最終更新日2022-09-21
実験手法ELECTRON MICROSCOPY (3.69 Å)
主引用文献A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Signal Transduct Target Ther, 7, 2022
7E9N
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BU of 7e9n by Molmil
Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab(1 down RBD, state1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 35B5 Fab, Light chain of 35B5 Fab, ...
著者Wang, X.F, Zhu, Y.Q.
登録日2021-03-04
公開日2022-04-06
最終更新日2022-09-21
実験手法ELECTRON MICROSCOPY (3.69 Å)
主引用文献A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Signal Transduct Target Ther, 7, 2022
7ENG
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BU of 7eng by Molmil
Cryo-EM structure of the SARS-CoV-2 S-6P in complex with Fab30 (local refinement of the RBD and Fab30)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab30, Light chain of Fab30, ...
著者Wang, X.F, Zhu, Y.Q.
登録日2021-04-16
公開日2022-04-06
最終更新日2022-09-21
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Signal Transduct Target Ther, 7, 2022
7ENF
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BU of 7enf by Molmil
Cryo-EM structure of the SARS-CoV-2 S-6P in complex with Fab30
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab30, ...
著者Wang, X.F, Zhu, Y.Q.
登録日2021-04-16
公開日2022-04-06
最終更新日2022-09-21
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Signal Transduct Target Ther, 7, 2022
7F46
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BU of 7f46 by Molmil
Cryo-EM structure of the SARS-CoV-2 S-6P in complex with 35B5 Fab (state1, local refinement of the RBD, NTD and 35B5 Fab)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of 35B5 Fab, Light chain of 35B5 Fab, ...
著者Wang, X.F, Zhu, Y.Q.
登録日2021-06-17
公開日2022-03-23
最終更新日2022-09-21
実験手法ELECTRON MICROSCOPY (4.79 Å)
主引用文献A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD
Signal Transduct Target Ther, 7, 2022
4OIM
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BU of 4oim by Molmil
Crystal structure of Mycobacterium tuberculosis InhA in complex with inhibitor PT119 in 2.4 M acetate
分子名称: 2-(2-CYANOPHENOXY)-5-HEXYLPHENOL, ACETATE ION, Enoyl-[acyl-carrier-protein] reductase [NADH], ...
著者Li, H.J, Pan, P, Lai, C.T, Liu, N, Garcia-Diaz, M, Simmerling, C, Tonge, P.J.
登録日2014-01-20
公開日2014-04-23
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.848 Å)
主引用文献Time-Dependent Diaryl Ether Inhibitors of InhA: Structure-Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy.
Chemmedchem, 9, 2014
7E5Y
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BU of 7e5y by Molmil
Molecular basis for neutralizing antibody 2B11 targeting SARS-CoV-2 RBD
分子名称: 2B11 Fab Heavy chain, 2B11 Fab Light chain, Spike protein S1
著者Wu, H, Yu, F, Wang, Q.S, Zhou, H, Wang, W.W, Zhao, T, Pan, Y.B, Yang, X.M.
登録日2021-02-21
公開日2021-06-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.59 Å)
主引用文献Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries.
Cell Discov, 7, 2021
7ELL
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BU of 7ell by Molmil
In situ structure of capping enzyme lambda2, penetration protein mu1 of mammalian reovirus capsid asymmetric unit.
分子名称: MYRISTIC ACID, Mu1, mRNA (guanine-N(7)-)-methyltransferase
著者Zhou, Z.H, Pan, M.
登録日2021-04-12
公開日2021-10-20
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor mu2 and capsid proteins.
Nat Commun, 12, 2021

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件を2024-06-12に公開中

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