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4MW6

Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[2-(benzyloxy)-5-chloro-3-(prop-2-en-1-yl)benzyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1476)

Summary for 4MW6
Entry DOI10.2210/pdb4mw6/pdb
Related4EG1 4EG3 4EG5 4MVW 4MVX 4MVY 4MW0 4MW1 4MW2 4MW4 4MW5 4MW7 4MW9 4MWB 4MWC 4MWD 4MWE
DescriptorMethionyl-tRNA synthetase, GLYCEROL, DIMETHYL SULFOXIDE, ... (6 entities in total)
Functional Keywordsaminoacyl-trna synthetase, aars, metrs, parasite, protein-inhibitor complex, rossmann fold, translation, nucleotide binding, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceTrypanosoma brucei
Total number of polymer chains2
Total formula weight124930.08
Authors
Koh, C.Y.,Kim, J.E.,Wetzel, A.B.,de van der Schueren, W.J.,Shibata, S.,Liu, J.,Zhang, Z.,Fan, E.,Verlinde, C.L.M.J.,Hol, W.G.J. (deposition date: 2013-09-24, release date: 2014-04-30, Last modification date: 2023-09-20)
Primary citationKoh, C.Y.,Kim, J.E.,Wetzel, A.B.,de van der Schueren, W.J.,Shibata, S.,Ranade, R.M.,Liu, J.,Zhang, Z.,Gillespie, J.R.,Buckner, F.S.,Verlinde, C.L.,Fan, E.,Hol, W.G.
Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
Plos Negl Trop Dis, 8:e2775-e2775, 2014
Cited by
PubMed: 24743796
DOI: 10.1371/journal.pntd.0002775
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.558 Å)
Structure validation

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